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Andrey Parkhitko

Harvard University

21

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1201

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Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

2019 Aging Cell
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Blocking p62/SQSTM1-dependent SMN degradation ameliorates Spinal Muscular Atrophy disease phenotypes

2018 Journal of Clinical Investigation
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p62/SQSTM1 cooperates with hyperactive mTORC1 to regulate glutathione production, maintain mitochondrial integrity and promote tumorigenesis

2017 Cancer Research
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Abstract A35: Regulation of the tumor microenvironment by oncogenic p62 in mTORC1-hyperactive diseases: Tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM)

2016 Cancer Research
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Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload

2015 Cardiovascular Pathology
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Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

2015 Proceedings of the National Academy of Sciences of the United States of America
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Abstract B09: Aspirin inhibits cyclooxygenase 2-mediated prostaglandin production and tumorigenesisin a preclinical model of tuberous sclerosis complex

2014 Molecular Cancer Research
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Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

2014 Journal of Experimental Medicine
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Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide

2014 Molecular Cancer Research
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Faslodex Inhibits Estradiol-Induced Extracellular Matrix Dynamics and Lung Metastasis in a Model of Lymphangioleiomyomatosis

2013 American Journal of Respiratory Cell and Molecular Biology
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