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John Alam

Biogen Idec

25

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Preclinical and Clinical Studies of p38α MAP kinase inhibition to Treat Basal Forebrain Cholinergic Dysfunction and Degeneration

2021
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Disease-modifying pharmacological approaches to correcting basal forebrain cholinergic neuronal (BFCN) dysfunction and degeneration.

2021 Neuropsychopharmacology
- John Alam
- Ralph A. Nixon
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Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level.

2020 PLOS ONE
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P38α MAPK Signaling-A Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease.

2020 International Journal of Molecular Sciences
- Ursula Germann
- John Alam
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ROLE OF P38α MAP KINASE IN AMYLOID-β DERIVED DIFFUSIBLE LIGAND (ADDL) INDUCED DENDRITIC SPINE LOSS IN HIPPOCAMPAL NEURONS

2019 Alzheimers & Dementia
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EFFECTS OF P38α MAP KINASE INHIBITION ON THE NEURODEGENERATIVE PHENOTYPE OF THE TS2 DOWN SYNDROME MOUSE MODEL

2019 Alzheimers & Dementia
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CHANGE IN VERBAL LEARNING TEST PERFORMANCE STRATIFIED BY BASELINE FLORBETAPIR PET STATUS OVER A SIX-MONTH INTERVAL IN THE ADNI-GO/ADNI2 DATASETS

2019 Alzheimers & Dementia
- John Alam
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160 Prove2 Study: Treatment of Chronic Hepatitis C with Telaprevir (TVR)in Combination with Peginterferon-Alfa-2a with or Without Ribavirin, Interim Analysis Results

2008 Gastroenterology
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Compositions et procedes destines au traitement de l'arthrite rhumatoide

2007
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Dosisformen mit vx-950 und ihr dosierschema

2005
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