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Sean Ottinger
Sean Ottinger
Takeda Pharmaceutical Company
Medicine
Pharmacology
Proteasome inhibitor
Ixazomib
QT interval
5
Papers
56
Citations
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A Phase 1 First-in-Human Study of the Anti-CD38 Dimeric Fusion Protein TAK-169 for the Treatment of Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM) Who Are Proteasome Inhibitor (PI)- and Immunomodulatory Drug (IMiD)-Refractory, Including Pts Relapsed/Refractory (R/R) or Naïve to Daratumumab (dara)
2019
Blood
Shaji Kumar
Robert F. Cornell
Ola Landgren
Sikander Ailawadhi
Jack P. Higgins
Erin Willert
Roger J. Waltzman
Jianchang Lin
Yuhong Zhang
Anya Lublinsky
Ajeeta B Dash
Michael J. Hanley
Divya Manoharan
Morgan Leichter
Sean Ottinger
Richard Labotka
John Newcomb
Alexander Vorog
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Citations (4)
Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats
2019
Journal of Pharmacological and Toxicological Methods
James J. Lynch
Emilie Rossignol
Joerg J. Moehrle
Terry R. Van Vleet
Kennan C. Marsh
Toufan Parman
Jon C. Mirsalis
Sean Ottinger
Jason A. Segreti
Mohan Rao
Scott W. Mittelstadt
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Citations (5)
Identification of microRNA biomarker candidates in urine and plasma from rats with kidney or liver damage
2017
Journal of Applied Toxicology
Francis S. Wolenski
Pooja Shah
Tomoya Sano
Tadahiro Shinozawa
Hugues Bernard
Matt J. Gallacher
Shylah D. Wyllie
Georgianna Varrone
Lisa A. Cicia
Mary Carsillo
Craig Fisher
Sean Ottinger
Erik Koenig
Patrick Kirby
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Citations (29)
Integrated nonclinical and clinical risk assessment of the investigational proteasome inhibitor ixazomib on the QTc interval in cancer patients
2015
Cancer Chemotherapy and Pharmacology
Neeraj Gupta
Yeamin Huh
Matthew M. Hutmacher
Sean Ottinger
Ai-Min Hui
Karthik Venkatakrishnan
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Citations (18)
Integrated nonclinical and clinical risk assessment to obviate the need for a dedicated QTc study of ixazomib citrate (MLN9708) in cancer patients (pts).
2014
Journal of Clinical Oncology
Neeraj Gupta
Yeamin Huh
Matthew M. Hutmacher
Sean Ottinger
Ai-Min Hui
Karthik Venkatakrishnan
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