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Katlyn A. Fleming
Katlyn A. Fleming
University of Minnesota
Receptor
Chemistry
Biochemistry
Melanocortin
Melanocortin receptor
7
Papers
68
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Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial Agonist
2019
Journal of Medicinal Chemistry
Katlyn A. Fleming
Katie T. Freeman
Mike D. Powers
Radleigh Santos
Ginamarie Debevec
Marc A. Giulianotti
Richard A. Houghten
Skye R. Doering
Clemencia Pinilla
Carrie Haskell-Luevano
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Synergistic Multi-Residue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists
2018
Journal of Medicinal Chemistry
Katlyn A. Fleming
Katie T. Freeman
Mark D. Ericson
Carrie Haskell-Luevano
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Structure–Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice
2018
ACS Chemical Neuroscience
Katlyn A. Fleming
Mark D. Ericson
Katie T. Freeman
Danielle N. Adank
Mary M. Lunzer
Stacey L. Wilber
Carrie Haskell-Luevano
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Citations (9)
Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles
2018
ACS Chemical Neuroscience
Mark D. Ericson
Zoe M. Koerperich
Katie T. Freeman
Katlyn A. Fleming
Carrie Haskell-Luevano
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Citations (2)
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016
2017
Biochimica et Biophysica Acta
Mark D. Ericson
Cody J. Lensing
Katlyn A. Fleming
Katherine N. Schlasner
Skye R. Doering
Carrie Haskell-Luevano
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Citations (33)
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