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Carla Scali

University of Florence

70

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Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery.

2016 Neurobiology of Disease
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A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

2014 Human Molecular Genetics
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Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity

2013 ACS Medicinal Chemistry Letters
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Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)

2012 Journal of Medicinal Chemistry
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Viral vector delivery of mutant huntingtin as model of huntington's disease in the rat: in vivo and in vitro study

2011
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Recombinant Adeno Associated Viral (AAV) vector delivery of mutant huntingtin as rat model for in vitro and in vivo studies.

2011
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Intrastriatal viral vector delivery of mutant huntingtin as rat model of Huntington’s Disease

2011
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Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625

2011 Psychopharmacology
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Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

2010 Journal of Neurochemistry
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Corrigendum to “SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist” [Bioorg. Med. Chem. 17 (2009) 5247]

2010 Bioorganic & Medicinal Chemistry
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