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Barbara M. Elcombe

University of Dundee

13

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252

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Combining in vivo and organotypic in vitro approaches to assess the human relevance of Basimglurant (RG7090), a potential CAR activator.

2020 Toxicological Sciences
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Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes

2018 Toxicology
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An evaluation of the mode of action (MoA) and human relevance of rat liver tumours observed in a chronic rat feeding study with silthiofam

2014 Toxicology Letters
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Evaluation of hepatic and thyroid responses in male Sprague Dawley rats for up to eighty-four days following seven days of dietary exposure to potassium perfluorooctanesulfonate.

2012 Toxicology
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Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR

2012 Toxicology
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P74—Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR

2012 Reproductive Toxicology
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A Mechanism for the induction of renal tumours in male Fischer 344 rats by short-chain chlorinated paraffins

2010 Archives of Toxicology
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Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR

2010 Archives of Toxicology
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Characterization of ammonium perfluorooctanoic acid (APFO) induced hepatomegaly in rats

2007 Toxicology
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Mechanism of carcinogenicity of a short chain chlorinated paraffin, Chlorowax 500C, in male fischer 344 rats in comparison to 1,4-dichlorobenzene and d-limonene

2000 Toxicology
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