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Makonen Belema

Bristol-Myers Squibb

46

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Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a]pyrazines from α-Aminoacetonitriles

2019 Synthesis
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The Discovery and Development of Daclatasvir: An Inhibitor of the Hepatitis C Virus NS5A Replication Complex

2019
- Nicholas A. Meanwell
- Makonen Belema
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Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097

2017 Journal of Organic Chemistry
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Synergistic Activity of Combined NS5A Inhibitors

2016 Antimicrobial Agents and Chemotherapy
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Case History: The Discovery of the First Hepatitis C Virus NS5A Replication Complex Inhibitor Daclatasvir (Daklinza™)

2016
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Daclatasvir (Daklinza): The First‐in‐Class HCV NS5A Replication Complex Inhibitor

2015
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HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity

2014 Journal of Medicinal Chemistry
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Discovery and development of hepatitis C virus NS5A replication complex inhibitors.

2014 Journal of Medicinal Chemistry
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Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

2014 Journal of Medicinal Chemistry
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HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.

2013 Bioorganic & Medicinal Chemistry Letters
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