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Irving M. London

Massachusetts Institute of Technology

51

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Determinants of specific RNA interference-mediated silencing of human β-globin alleles differing by a single nucleotide polymorphism

2006 Proceedings of the National Academy of Sciences of the United States of America
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Correction of sickle cell disease in transgenic mouse models by gene therapy

2001 Science
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Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.

2000 Proceedings of the National Academy of Sciences of the United States of America
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Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis.

1999 Oncogene
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The Effects of Pyrroloquinoline Quinone on Heme-Regulated eIF-2α Kinase and eIF-2B Activities in Eukaryotic Protein Synthesis

1997 Blood Cells Molecules and Diseases
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- HRI: Haem-regulated eIF-2α kinase (vertebrates) (Haem-regulated inhibitor, haem-controlled repressor, HCR)

1995
- Jane-Jane Chen
- Irving M. London
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Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.

1995 Proceedings of the National Academy of Sciences of the United States of America
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Regulation of protein synthesis by heme-regulated eIF-2α kinase

1995 Trends in Biochemical Sciences
- Jane-Jane Chen
- Irving M. London
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Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

1995 Journal of Biological Chemistry
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Recycling and phosphorylation of eukaryotic initiation factor 2 on 60S subunits of 80S initiation complexes and polysomes

1992 Proceedings of the National Academy of Sciences of the United States of America
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