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Jason Roland

Genomics Institute of the Novartis Research Foundation

15

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Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors

2021 ACS Medicinal Chemistry Letters
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Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH)

2020 Journal of Medicinal Chemistry
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

2018 bioRxiv
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

2018
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Development of LMB763, a novel, orally bioavailable, clinical farnesoid X receptor agonist for the treatment of non-alcoholic steatohepatitis and hepatobiliary disorders

2017 Journal of Hepatology
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Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation

2017 ACS Chemical Biology
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Dissociated sterol-based liver X receptor agonists as therapeutics for chronic inflammatory diseases

2016 The FASEB Journal
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KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage Parasites In Vitro.

2014 Antimicrobial Agents and Chemotherapy
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Targeting Plasmodium phosphatidylinositol-4 kinase for the treatment, prevention and elimination of malaria

2013
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