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Deborah F. Smith

Imperial College London
Hull York Medical School
University of York

165

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9711

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Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

2020 Parasites & Vectors
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Novel thienopyrimidine inhibitors of Leishmania N-myristoyltransferase with on-target activity in intracellular amastigotes

2020 Journal of Medicinal Chemistry
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A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

2017 PLOS Neglected Tropical Diseases
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Leishmania HASP and SHERP Genes are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

2017 PLOS Pathogens
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Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite Trypanosoma brucei

2016 ACS Infectious Diseases
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Leishmania major N-myristoyltransferase in complex with a chlorophenyl inhibitor (compound 10j).

2016
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Hybridization in parasites: consequences for adaptive evolution, pathogenesis, and public health in a changing world.

2015 PLOS Pathogens
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Global Analysis of Protein N-Myristoylation and Exploration of N-Myristoyltransferase as a Drug Target in the Neglected Human Pathogen Leishmania donovani

2015 Chemistry & Biology
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Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

2015 MedChemComm
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Leishmania major N-myristoyltransferase in complex with a pyrrolidine inhibitor.

2014
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