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Matthew J. Bruns
Matthew J. Bruns
Pfizer
Biochemistry
Chemistry
T cell
Potassium channel
Pharmacophore
4
Papers
180
Citations
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UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation
1999
British Journal of Pharmacology
Douglas C. Hanson
A. N. Nguyen
Robert J. Mather
Heiko Rauer
Kevin Koch
Laurence E. Burgess
Rizzi Jp
Carol B. Donovan
Matthew J. Bruns
Paul C. Canniff
Ann C. Cunningham
Kimberly A. Verdries
E. Edward Mena
John Charles Kath
George A. Gutman
Michael D. Cahalan
Stephan Grissmer
K. George Chandy
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Citations (58)
The SAR of UK-78,282: a novel blocker of human T cell Kv1.3 potassium channels
1997
Bioorganic & Medicinal Chemistry Letters
Laurence E. Burgess
Kevin Koch
Kelvin Cooper
M. S. Biggers
M. Ramchandani
Jacqueline H. Smitrovich
Eric J. Gilbert
Matthew J. Bruns
Robert J. Mather
Carol B. Donovan
Douglas C. Hanson
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Citations (18)
The SAR of UK-78,282: a novel blocker of human T cell Kv1.3 potassium channels
1997
Bioorganic & Medicinal Chemistry Letters
Laurence E. Burgess
Kevin Koch
Kelvin Cooper
Michael S. Biggers
Mukesh Ramchandani
Jacqueline H. Smitrovich
Eric J. Gilbert
Matthew J. Bruns
Robert J. Mather
Carol B. Donovan
Douglas C. Hanson
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Citations (15)
Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.
1996
Molecular Pharmacology
A. N. Nguyen
John Charles Kath
Douglas C. Hanson
Michael S. Biggers
Paul C. Canniff
Carol B. Donovan
Robert J. Mather
Matthew J. Bruns
Heiko Rauer
Jayashree Aiyar
A Lepple-Wienhues
George A. Gutman
Stephan Grissmer
Michael D. Cahalan
K G Chandy
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Citations (89)
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