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Josee Cote

Merck & Co.

35

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1786

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Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.

2021 Journal of Medicinal Chemistry
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Chronic Administration of Anacetrapib Is Associated With Accumulation in Adipose and Slow Elimination

2017 Clinical Pharmacology & Therapeutics
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Observed Long Plasma Terminal Half-life Of Anacetrapib Is Associated With Adipose Deposition: Plasma And Adipose Pharmacokinetics In Mice And Humans: Pi-050

2015 Clinical Pharmacology & Therapeutics
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Effects of Rifampin, a Potent Inducer of Drug-Metabolizing Enzymes and an Inhibitor of OATP1B1/3 Transport, on the Single Dose Pharmacokinetics of Anacetrapib

2013 The Journal of Clinical Pharmacology
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(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.

2012 Journal of Medicinal Chemistry
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Laropiprant in Combination With Extended‐Release Niacin Does Not Alter Urine 11‐Dehydrothromboxane B2, a Marker of In Vivo Platelet Function, in Healthy, Hypercholesterolemic, and Diabetic Subjects

2009 The Journal of Clinical Pharmacology
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Effect of Sitagliptin on the Pharmacokinetics of Simvastatin

2009 The Journal of Clinical Pharmacology
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Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects.

2008 Clinical Pharmacology & Therapeutics
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Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of Taranabant, a Novel Selective Cannabinoid-1 Receptor Inverse Agonist, in Healthy Male Volunteers

2008 The Journal of Clinical Pharmacology
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The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake

2008 Cell Metabolism
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Citations (192)