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Chin Liu
Chin Liu
Eli Lilly and Company
Aggrecanase
Biochemistry
Aggrecan
Chemistry
Osteoarthritis
5
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80
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A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose
2017
Journal of Medicinal Chemistry
Timothy B. Durham
Jothirajah Marimuthu
James Lee Toth
Chin Liu
Lisa A. Adams
Daniel R. Mudra
C.A. Swearingen
C. Lin
Mark Chambers
Kannan Thirunavukkarasu
Michael Robert Wiley
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Citations (8)
Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors
2016
Journal of Medicinal Chemistry
Michael Robert Wiley
Timothy B. Durham
Lisa A. Adams
Mark Chambers
C. Lin
Chin Liu
Jothirajah Marimuthu
P.G. Mitchell
Daniel R. Mudra
C.A. Swearingen
James Lee Toth
Jennifer Weller
Kannan Thirunavukkarasu
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Citations (4)
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
2014
Journal of Medicinal Chemistry
Timothy B. Durham
Valentine J. Klimkowski
Christopher John Rito
Jothirajah Marimuthu
James Lee Toth
Chin Liu
Jim D. Durbin
Stephanie L. Stout
Lisa A. Adams
Craig Swearingen
C. Lin
Mark Chambers
Kannan Thirunavukkarasu
Michael Robert Wiley
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Citations (17)
Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine
2010
Osteoarthritis and Cartilage
C.A. Swearingen
J.W. Carpenter
Robert W. Siegel
I.J. Brittain
Joe Edward Dotzlaf
Timothy B. Durham
James Lee Toth
D. A. Laska
Jothirajah Marimuthu
Chin Liu
D.P. Brown
Quincy L. Carter
Michael Robert Wiley
Kevin Duffin
P.G. Mitchell
Kannan Thirunavukkarasu
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Citations (32)
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.
2010
Osteoarthritis and Cartilage
C.A. Swearingen
Mark Chambers
C. Lin
Jothirajah Marimuthu
Christopher John Rito
Quincy L. Carter
Joe Edward Dotzlaf
Chin Liu
Srinivasan Chandrasekhar
Kevin Duffin
P.G. Mitchell
Timothy B. Durham
Michael Robert Wiley
Kannan Thirunavukkarasu
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Citations (19)
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