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Mohammad Hekmat-Nejad

Novartis

12

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176

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Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

2019 Journal of Medicinal Chemistry
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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

2018 Cancer Research
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Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

2017 Journal of Medicinal Chemistry
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Inhibition of prenylated KRAS in a lipid environment

2017 PLOS ONE
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Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

2016 Cancer Research
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Expression, purification and characterization of inactive and active forms of ERK2 from insect expression system.

2015 Protein Expression and Purification
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Abstract LB-28: RAF inhibitors activate MAPK pathway through relief of RAF auto-inhibition

2011 Cancer Research
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Crystal Structure of Internal Kinesin Motor Domain

2004
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