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John R. Murphy

Harvard University

47

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Abstract 1202: Target identification for a new type of ADC

2016 Cancer Research
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Abstract 953: An anti-CD38 antibody drug conjugate for the treatment of diverse hematologic malignancies

2015 Cancer Research
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Genetic and biophysical studies of diphtheria toxin repressor (DtxR) and the hyperactive mutant DtxR(E175K) support a multistep model of activation

2004 Proceedings of the National Academy of Sciences of the United States of America
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Metal stoichiometry and functional studies of the diphtheria toxin repressor

2003 Proceedings of the National Academy of Sciences of the United States of America
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Fusion protein toxins based on diphtheria toxin: Selective targeting of growth factor receptors of eukaryotic cells

2000 Methods in Enzymology
- Johanna C. vanderSpek
- John R. Murphy
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Isolation and characterization of iron-independent positive dominant mutants of the diphtheria toxin repressor DtxR.

1998 Proceedings of the National Academy of Sciences of the United States of America
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The effects of helix breaking mutations in the diphtheria toxin transmembrane domain helix layers of the fusion toxin DAB389IL-2.

1998 Protein Engineering
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Inhibition of Protein Synthesis in Small Cell Lung Cancer Cells Induced by the Diphtheria Toxin-related Fusion Protein DAB389 GRP

1997 Cancer Research
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DAB389 Interleukin-2 Receptor Binding Domain Mutations CYTOTOXIC PROBES FOR STUDIES OF LIGAND-RECEPTOR INTERACTIONS

1996 Journal of Biological Chemistry
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Genetic construction and properties of a diphtheria toxin-related substance P fusion protein: in vitro destruction of cells bearing substance P receptors

1996 Proceedings of the National Academy of Sciences of the United States of America
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