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Scott K. Durum

National Institutes of Health

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Mutations that collaborate with IL-7Ra signaling pathways to drive ALL

2021 Advances in biological regulation
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Abstract 2462: A combination of IL7Rα and NRAS mutations up-regulates Bcl-2 and cMyc levels leading to formation of T-cell acute lymphoblastic leukemia

2021
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Abstract B57: A combination of IL7Rα and NRAS mutations sheds light on the oncogenesis of T-cell acute lymphoblastic leukemia in a murine model

2020 Cancer Research
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Overexpression of hTLX3 in Association with Mutant IL7Rα Is Sufficient to Generate T-ALL In Vivo and to Transform Thymocytes inVitro

2020 Blood
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Oral epithelial IL-22/STAT3 signaling licenses IL-17–mediated immunity to oral mucosal candidiasis

2020 Science immunology
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Abstract B47: Overexpression of TLX3 or HOXA9 in association mutant IL7Rα are sufficient to generate T-ALL in vivo

2020 Cancer Research
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Flip the coin: IL-7 and IL-7R in health and disease

2019 Nature Immunology
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NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

2019 Oncogene
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Clonal Vγ6+Vδ4+ T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection

2019 Proceedings of the National Academy of Sciences of the United States of America
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A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

2019 Leukemia
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