Quantitative MRI and strength measurements in the assessment of muscle quality in Duchenne muscular dystrophy
Beatrijs WokkeJ.C. van den BergenMaarten J. VersluisE. NiksJulien MillesAndrew WebbErik W. van ZwetAnnemieke Aartsma‐RusJan J.G.M. VerschuurenHermien E. Kan
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Keywords:
Triceps surae muscle
Quadriceps femoris muscle
Muscle Atrophy
Leg muscle
Muscle contracture
Kassiano, W, Costa, B, Kunevaliki, G, Soares, D, Stavinski, N, Francsuel, J, Carneiro, MAS, Tricoli, I, Nunes, JP, Ribeiro, AS, and Cyrino, ES. Muscle swelling of the triceps surae in response to straight-leg and bent-leg calf raise exercises in young women. J Strength Cond Res 37(7): e438-e443, 2023-Triceps surae muscle swelling in response to different resistance exercises remains to be determined. This study compared the effects of straight-leg (STRA-leg) calf raise vs. bent-leg (BENT-leg) calf raise exercises on triceps surae muscle swelling. Seventeen young women (23.7 ± 4.0 years; 67.4 ± 16.0 kg; and 163.5 ± 7.2 cm) performed 2 resistance training sessions; in one, they performed the STRA-leg calf raise, and in another, they performed the BENT-leg calf raise. A randomized, cross-over, and counterbalanced design was adopted for this investigation. The subjects performed 4 sets of 20 repetitions maximum until concentric muscular failure. The muscle thickness of the gastrocnemius medial (GM), gastrocnemius lateral (GL), and soleus (SOL) was taken through B-mode ultrasound before and immediately after the calf raise exercises. STRA-leg calf raise elicited greater increases in muscle thickness of GM (+8.8% vs. -0.9%, p < 0.001) and GL (+14.5% vs. +7.0%, p < 0.001) than BENT-leg calf raise. Conversely, BENT-leg calf raise elicited greater increases in SOL muscle thickness than STRA-leg calf raise (+15.4% vs. +7.7%, p < 0.001). From a practical perspective, the STRA-leg calf raise should be preferred if the aim is stimulating the 3 muscles that comprise the triceps surae, whereas the BENT-leg calf raise should be prioritized if the target muscle is the SOL.
Triceps surae muscle
Calf muscle
Leg muscle
Gastrocnemius muscle
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The purpose of this investigation was to use electromyography (EMG) combined with pattern classification procedures to examine differences in activation among the superficial quadriceps femoris muscles during fatiguing concentric isokinetic muscle ac
Leg muscle
Quadriceps femoris muscle
Isokinetic Exercise
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The contractile properties of the triceps surae were evaluated in 11 patients after unilateral fracture of the lower leg and subsequent immobilization for 135 +/- 68 days. Calf muscle cross-sectional area (plus bone: CSA) was assessed from anthropometric measurement. It was shown that the injured leg had a faster time to peak tension and increased half-relaxation time (1/2 RT); twitch force (Pt) was reduced by 25%. Evoked maximal tetanic tensions (Po) at 10 and 20 Hz were reduced by 51% and 46% respectively compared with the uninjured leg. The force of a maximal voluntary contraction (MVC) was also reduced, by 50%, but calf circumference and CSA were only 5% and 16% respectively lower in the injured leg. It was concluded that the changes in contractile speed may indicate a relatively greater atrophy of slow (type I) muscle fibres. The relationship between CSA and tension generation in the injured limb was shown to be poor after immobilization and during recovery. Anthropometric estimation of CSA does not appear to reflect the degree of muscle wasting, as indicated by reduced tension development after immobilization.
Triceps surae muscle
Leg muscle
Time to peak
Circumference
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본 연구에서는 하지 골절 후 회복기 환자에게 러시안전류 자극이 넙다리네갈래근의 근수행력과 활성도에 미치는 영향을 알아보기 위하여 실시하였다. 본 연구는 2013년 1월 9일에서 2013년 3월 16일까지 실시하였으며, 하지 골절 후 회복기에 있는 환자 20명을 대상으로 실험을 실시하였다. 러시아 전류자극기의 큰 도자를 넙다리네갈래근의 근위부에 위치하고, 작은 도자는 원위부에 부착시키고 한 주에 세 번, 6주 동안 적용하였다. 대상자의 넙다리네갈래근의 근활성도를 측정하기 위해 근전도가 이용되었고, 근수행력을 측정하기 위해 등속성기기가 이용되었다. 연구결과 기간별 넙다리네갈래근의 근수행력 차이는 러시안전류 치료 전과 비교하여 4주 후와 6주 후에서 유의한 근수행력의 증가를 나타내었다. 또한 넙다리곧은근, 안쪽넓은근, 가쪽넓은근의 근활성도는 치료 전과 비교하여 4주 후와 6주에서 유의한 증가를 나타내었다. 이와 같은 결과는 러시안 전류가 하지 골절 등과 같은 문제로 인해 약화된 하지 근육의 근력 강화를 위해 선택될 수 있는 효과적 치료 방법이라 할 수 있다. The present study was aimed to comprehend the effect of the Russian current stimulation on the muscular performance and activity of quadriceps femoris muscle of the convalescent patient after the leg fracture.This study conducted test based on 20 patients after leg fracture. Russian current was applied for six weeks as three times in a week, between January 9, 2013 and 15 March 16, 2013. The electromyogram was used to measure the muscle activity of the quadriceps femoris, and the isokinetic equipment was used to measure the muscular performance. The muscular performance difference by duration depending on the application of the Russian current showed the significant increase in all muscular performances. The activity of all muscles of the quadriceps femoris muscle by duration showed significant increase. These results showed that the Russian current can be the effective treatment method for enhancing the muscular strength of the weakened lower limbs muscle due to the problem such as the leg fracture.
Quadriceps femoris muscle
Quadriceps muscle
Leg muscle
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Abstract The biomechanics underlying bouncing exercises are characterized by the spring-like behavior of the human leg. However, the mechanism underlying the mechanistic contribution of muscle dynamics to the adjustment of leg stiffness is unclear. This study aimed to elucidate the mechanisms governing the changes in leg stiffness during hopping at different frequencies by examining the dynamics of the muscle–tendon complex (MTC) of the medial gastrocnemius muscle (MG). We hypothesized that an increase in muscle stiffness would augment leg stiffness, thereby enabling hopping at higher frequencies. Kinematic and kinetic data were obtained using a motion capture system and force plates. Simultaneously, ultrasound images of the MG were acquired to quantify the muscle fascicle length and pennation angle. The results showed that the stiffness of the MTC increased with hop frequency and exhibited a strong correlation with the leg stiffness. In addition, with increasing frequency, the fascicle contractions shifted from isometric to concentric. To explain these results, an MTC model comprising a contractile component (CC) and series elastic component (SEC) was constructed. We observed a negative CC stiffness, which increased the MTC stiffness. Although this result appears to diverge from our initial hypothesis, the effect of negative CC stiffness on MTC stiffness can be understood, from the perspective of two springs in series, as an extension of the very high stiffness effect. This quantitative understanding of the dynamic interaction between the muscle and tendon offers a unified framework for interpreting various results of previous studies on fascicle dynamics during hopping.
Fascicle
Muscle stiffness
Biomechanics
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Triceps surae muscle
Bioelectrical Impedance Analysis
Quadriceps femoris muscle
Intensity
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Triceps surae muscle
Quadriceps femoris muscle
Muscle Atrophy
Leg muscle
Muscle contracture
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The study aimed to investigate the effect of low-frequency electrical stimulation (LFES) on disuse muscle atrophy and its mechanism in a rabbit model of knee extension contracture.This study involved two experiments. In the time-point experiment, 24 rabbits were randomly divided into 4 groups: Control 1 (Ctrl1 group), immobilization for 2 weeks (I-2 group), immobilization for 4 weeks (I-4 group), and immobilization for 6 weeks (I-6 group). In the intervention experiment, 24 rabbits were randomly divided into 4 groups: Control 2 (Ctrl2 group), electrical stimulation (ESG group), natural recovery (NRG group), and electrical stimulation treatment (ESTG group). All intervention effects were assessed by evaluating the knee joint range of motion (ROM), cross-sectional area (CSA) of the rectus femoris muscle, and expression of autophagy-related proteins.The time-point experiment showed that immobilization reduced the knee ROM, reduced the rectus femoris muscle CSA, and activated autophagy in skeletal muscle. The levels of five autophagy-related proteins [mammalian target of rapamycin (mTOR), phosphorylated mTOR (p-mTOR), autophagy-related protein 7 (Atg7), p62, and microtubule-associated protein light chain 3B-II (LC3B-II)] were significantly elevated in the skeletal muscle of the I-4 group. The intervention experiment further showed that LFES significantly improved the immobilization-induced reductions in ROM and CSA. Additionally, LFES resulted in a significant decrease in the protein expression of mTOR, p-mTOR, Atg7, p62, and LC3B-II in the rectus femoris muscle.LFES alleviates immobilization-evoked disuse muscle atrophy possibly by inhibiting autophagy in the skeletal muscle of rabbits.
Muscle Atrophy
Quadriceps femoris muscle
Rectus femoris muscle
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Abstract Knee osteoarthritis (KOA) usually leads to quadriceps femoris atrophy, which in turn can further aggravate the progression of KOA. Curcumin (CUR) has anti-inflammatory and antioxidant effects and has been shown to be a protective agent for skeletal muscle. CUR has been shown to have a protective effect on skeletal muscle. However, there are no studies related to whether CUR improves KOA-induced quadriceps femoris muscle atrophy. We established a model of KOA in rats. Rats in the experimental group were fed CUR for 5 weeks. Changes in autophagy levels, reactive oxygen species (ROS) levels, and changes in the expression of the Sirutin3 (SIRT3)-superoxide dismutase 2 (SOD2) pathway were detected in the quadriceps femoris muscle of rats. KOA led to quadriceps femoris muscle atrophy, in which autophagy was induced and ROS levels were increased. CUR increased SIRT3 expression, decreased SOD2 acetylation and ROS levels, inhibited the over-activation of autophagy, thereby alleviating quadriceps femoris muscle atrophy and improving KOA. CUR has a protective effect against quadriceps femoris muscle atrophy, and KOA is alleviated after improvement of quadriceps femoris muscle atrophy, with the possible mechanism being the reduction of ROS-induced autophagy via the SIRT3-SOD2 pathway.
SOD2
Quadriceps femoris muscle
Muscle Atrophy
SIRT3
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Muscle atrophy is common in patients with rheumatoid arthritis (RA). Although neuromuscular electrical stimulation (NMES) is a viable treatment for muscle atrophy, there is no evidence about the use of NMES in patients with RA. The purposes of this multiple-patient case report are: (1) to describe the use of NMES applied to the quadriceps femoris muscles in conjunction with an exercise program in patients with RA; (2) to report on patient tolerance and changes in lean muscle mass, quadriceps femoris muscle strength (force-producing capacity), and physical function; and (3) to explore how changes in muscle mass relate to changes in quadriceps femoris muscle strength, measures of physical function, and patient adherence.Seven patients with RA (median age=61 years, range=39-80 years) underwent 16 weeks of NMES and volitional exercises. Lean muscle mass and strength of the quadriceps femoris muscle and physical function were measured before and after treatment.One patient did not tolerate the NMES treatment, and 2 patients did not complete at least half of the proposed treatment. Patients who completed the NMES and volitional exercise program increased their lean muscle mass, muscle strength, and physical function.Because of the small sample, whether NMES combined with exercises is better than exercise alone or NMES alone could not be determined. However, the outcomes from this multiple-patient case report indicate that NMES is a viable treatment option to address muscle atrophy and weakness in patients with RA. Strategies to increase tolerance and adherence to NMES are warranted.
Muscle Atrophy
Quadriceps femoris muscle
Muscle weakness
Quadriceps muscle
Electrical muscle stimulation
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