Matrix Metalloproteinases(MMPs)and Tissue Inhibitors of Metalloproteinases(TIMPs)in the Development and Disease of Oral Tissues
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Matrix (chemical analysis)
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基质金属蛋白酶(Matrix metalloproteinases,MMPs)是一类能降解细胞外基质成分的重要蛋白酶类,具有促进恶性肿瘤侵袭转移的作用.金属蛋白酶组织抑制因子(tissue inhibitors of metalloproteinases,TIMPs)可以特异性抑制MMPs活性.本文就基质金属蛋白酶及其抑制因子与膀胱癌关系的研究进展作一综述。
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Matrix (chemical analysis)
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Tissue Remodeling
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The matrix metalloproteinases(MMP)are a large family of proteolytic enzymes,which play important roles in the degradation of the extracellular matrix.The tissue inhibitor of metalloproteinases(TIMP)are the natural inhibitors of MMP.There is increasing evidence to indicate that imbalance of MMP and TIMP have something to do with various pathologic mechanisms,especially in tumour invasion and metastasis.In this paper,the property,structure,and function of MMP and TIMP were reviewed.
Proteolytic enzymes
Matrix metalloproteinase inhibitor
Matrix (chemical analysis)
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Several families of enzymes are responsible for the degradation of extracellular matrix (ECM) proteins during the remodeling of tissues. An important family of such enzymes is that of the matrix metalloproteinases (MMPs). To control MMP-mediated ECM breakdown, tissue inhibitors of metalloproteinases (TIMPs) are able to inhibit MMP activity. A disturbed balance of MMPs and TIMPs is found in various pathologic conditions, such as cancer, rheumatoid arthritis, and periodontitis. The role of MMPs in pathology has been extensively described in the literature. The main focus of this review lies in the biological functions of TIMPs and their occurrence in disease, especially in the head and neck area. Their biological functions and their role in diseases like oral cancers and periodontitis, and in the development of cleft palate, will be discussed. Finally, the diagnostic and therapeutical opportunities of TIMPs will be evaluated.
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Regulation of matrix metalloproteinases (MMP) and tissue inhibitors of MMP (TIMP) have been implicated in the pathogenesis of pulmonary hypertension (PH) in animal models. Whether plasma profiles o...
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