THE CARDIOVASCULAR EFFECTS OF DOPAMINE : (Part II)

We gave people four different dopamine agonists and monitored blood pressure, heart rate and circulating catecholamine levels. Bromocriptine decreased blood pressure and plasma norepinephrine levels. Dopamine increased pulse pressure, heart rate and circulating epinephrine (E) and norepinephrine (NE) levels. Dopamine agonists tend to diminish blood pressure by inhibiting sympathetic neuronal discharge of NE and, to a lesser extent, by stimulating dopamine vascular receptors. However, dopamine and L-dopa can be converted to NE and E, both of which have pressor effects. The complex cardiovascular effects of dopamine agonists are the result of stimulation of dopamine vascular and neuronal receptors and the production of NE and E.

Sympathetic nervous system

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Dopamine and hypertension

Current Opinion in Cardiology (1990)

Otto Kuchel

Clinical Research Institute of Montreal and Hôtel-Dieu Hospital, University of Montreal, Montreal, Quebec, Canada Current Opinion in Cardiology 1990, 5:594–600

10.1097/00001573-199010000-00004

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Citations (7)

Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson’s disease

Journal of neural transmission. Supplementum (2003)

M. Gerlach Kay L. Double Heinz Reichmann Peter Riederer

10.1007/978-3-7091-0643-3_10

Cite

Citations (21)

Dopamine autoreceptor stimulation: Clinical significance

Pharmacology Biochemistry and Behavior (1982)

Herbert Y. Meltzer