53982 Measurement of musculoskeletal symptoms in patients with hidradenitis suppurativa: preliminary evaluation of the IDEOM MSK-Q’s content validity
Lourdes M. Perez‐ChadaArianna ZhangGretchen BallMichael J. WoodburyMelissa P. ZundellApril W. ArmstrongVibeke StrandJoseph F. MerolaAlice B. Gottlieb
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Hidradenitis Suppurativa
Content Validity
Hidradenitis suppurativa is a chronic skin disease characterized by inflammation and disfiguring scarring in the intertriginous body areas. Hidradenitis suppurativa is associated with overweight and impaired quality of life. This study sought to describe Body Image Quality of Life (BI-QoL) in patients with hidradenitis suppurativa and to compare it with patients with other skin diseases (controls). A total of 285 participants were recruited, 141 with hidradenitis suppurativa and 144 controls, at the Department of Dermatology at Zealand University Hospital, Denmark (during 2017-18). The Danish "Body Image Quality of Life Inventory" questionnaire measured BI-QoL. Patients with hidradenitis suppurativa had significantly lower mean BI-QoL than controls: Hidradenitis suppurativa BI-QoL (standard deviation; SD) -0.87 (0.98) vs. control BI-QoL (SD) 0.01 (1.11), p < 0.001. Predictors of negative BI-QoL were hidradenitis suppurativa, increased body mass index, female sex, symptoms of depression, and body mass index moderated by hidradenitis suppurativa. These data suggest that BI-QoL is impaired in patients with hidradenitis suppurativa compared with patients with other skin diseases after adjusting for confounders.
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Hidradenitis suppurativa (HS) is a debilitating, chronic, painful inflammatory disease. Scientists have previously suggested that there is a potential genetic link predisposing Down syndrome patients to the development of HS through the increased formation of the amyloid precursor protein. However, this laboratory based finding had not previously been verified in the population. In this study, we evaluated the commonness of hidradenitis suppurativa within a large group of patients who had Down syndrome, and we used another groups of patients that did not have Down syndrome to compare findings. We observed that the diagnosis of hidradenitis suppurativa was present among 2.1% of patients with Down syndrome over the past five years. Compared to those without Down syndrome, patients with the condition had five times the likelihood of having hidradenitis suppurativa during the period of the study. Hidradenitis suppurativa was most common among Down syndrome patients who were aged 18–29 years. Hidradenitis suppurativa affected males and females, and whites and non‐whites, with Down syndrome equally. The diagnosis of hidradenitis suppurativa is made at a younger age among patients with Down syndrome, compared to patients without the condition. This suggests that hidradenitis may occur earlier in life among patients with Down syndrome, or it may occur more severely and thereby prompt earlier visits to the doctor for this condition. It is also possible that hidradenitis suppurativa is diagnosed earlier among patients with Down syndrome because doctors may be examining patients with Down syndrome more frequently in general.
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Abstract Hidradenitis suppurativa is a chronic, painful, autoinflammatory condition resulting in nodules, abscesses and sinus tracts. We present an evidence‐based review providing new understanding of the pathogenesis of hidradenitis suppurativa and associated comorbidities. By the nature of their speciality, dermatologists are uniquely positioned to investigate and treat patients.
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Hidradenitis Suppurativa
Apocrine
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Severe levels of illness, measured through patient-reported outcomes, are frequent among patients with hidradenitis suppurativa classified as having mild disease according to the International Hidradenitis Suppurativa Score System. The systematic use in clinical practice of patient-centred outcome measures, capable of accurately detecting and portraying the true severity of the impact of skin conditions, may help improve patient care.
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Background: Hidradenitis suppurativa (HS), a chronic skin condition that causes pain and physical dysfunction, can impact significantly on quality of life. Disease‑specific tools have been designed to assess the patient impact of HS, including the HS Symptom Daily Diary (HSSDD), the HS Symptom Questionnaire (HSSQ) and the HS Quality of Life (HiSQOL©) questionnaire, which have been developed into electronic instruments (eHSSDD, eHSSQ and eHiSQOL©). Objectives: To establish the content validity of the electronic version of the HSSDD and HSSQ, and the acceptability and usability of the HSSDD, HSSQ and HiSQOL© using concept elicitation and cognitive debriefing interviews. Methods: This was a non‑interventional qualitative video interview study involving participants aged ≥18 years with moderate to severe HS recruited from a single clinical site in the USA. Interviews gathered feedback on participants’ symptom experience, followed by training and completion of the eHSSDD, eHSSQ, and eHiSQOL© questionnaires on electronic hand-held devices. Participants were then interviewed on the content of the eHSSDD and eHSSQ, and the acceptability and usability of all three instruments. Interviews were transcribed and qualitatively analysed. Results: Twenty participants with moderate to severe HS (median age: 41.5 [range: 20.0–64.0]; n=16/20 female) were included. All participants found the eHSSDD, eHSSQ and eHiSQOL© instructions clear, and described the instruments as ‘easy’, ’simple’ and ’self-explanatory’. Overall understanding of individual items within the eHSSDD and eHSSQ was high; however, 6/20 participants had difficulty in understanding the ‘average skin pain’ item in the eHSSDD. All participants were able to accurately recall their symptoms within the recall periods of the eHSSDD and eHSSQ, although 4/20 participants found the 24-hour recall period of the eHSSDD limiting. Completion time was quick across all instruments and usability was high, with the majority of participants reporting no difficulty in completing questionnaires on electronic devices. Conclusion: The concepts covered in the eHSSDD and eHSSQ are relevant and important to patients, supporting their content validity. The findings also provide evidence of acceptability and usability of the eHSSDD, eHSSQ, and eHiSQOL©. A limitation was that all participants were recruited from a single site, which may have introduced selection bias and thus limit the generalisability of results.
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Many dermatologic and systemic diseases have been reported in association with hidradenitis suppurativa, but its association with Down syndrome is rarely mentioned in the literature. The objective of the current study was to assess the frequency of hidradenitis suppurativa in patients with Down syndrome who visited our clinic over 4 years.We recorded the presenting complaints and dermatologic problems of patients with Down syndrome who visited our clinic from January 2011 to December 2014. Medical photographs were taken. Patients with hidradenitis suppurativa were assessed according to severity and treated with topical and systemic medications.Twenty-nine new patients with Down syndrome visited our clinic during this period. Eleven had hidradenitis suppurativa. Disease severity included Hurley stages I and II.The presence of hidradenitis suppurativa in 38% of patients with Down syndrome is far higher than would be expected by chance alone.
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Hidradenitis suppurativa is a chronic, debilitating inflammatory skin disease. Case reports of individuals with hidradenitis suppurativa presenting exclusively on the face, as well as reports of individuals with HIV and hidradenitis suppurativa, are rare. Here, we present the case of an HIV-positive man who presented with hidradenitis suppurativa localized only on his face. We also review facial hidradenitis suppurativa and hidradenitis suppurativa in HIV patients.
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Hidradenitis Suppurativa
Apocrine
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Abstract Hidradenitis suppurativa is a chronic, painful, autoinflammatory condition resulting in nodules, abscesses and sinus tracts. We present an evidence‐based review providing new understanding of the pathogenesis of hidradenitis suppurativa and associated comorbidities. By the nature of their speciality, dermatologists are uniquely positioned to investigate and treat patients with this condition. Data collected from a subspecialty hidradenitis suppurativa clinic ( N = 106) and experiences thereof are discussed in this review.
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