Copper (II)-catalyzed polydopamine mediated photothermal sensors for visual quantitative point-of-care testing
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Point-of-Care Testing
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Background: Use of point-of-care testing (POCT) in primary care has increased. There is a need for high-quality field evaluation of POCT before deployment can be considered. Method: A POCT system for C-reactive protein was evaluated in a routine general practice setting. The standard laboratory method was a dry slide method based in a routine hospital laboratory. Results: Scatterplots for both venous and capillary blood POCT system results versus the standard laboratory assay produced correlation coefficients of greater than 0·96. Bland-Altman plots indicated that 95% of venous and capillary POCT results fell within ±10 mg/L of the mean value with no clinically significant difference from laboratory results. Conclusions: The POCT system performed reliably in a routine general practice setting with satisfactory performance against an accepted laboratory method.
Point-of-Care Testing
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POCT（point of care testing）は，臨床現場で検査が即時に行われ，結果が即時に臨床に利用されるシステムである．救急医療では，臨床検査には，①迅速性，②簡便性，③随時性ならびに④反復性を求められるが，POCTはこれらの全ての要件を満たしている．一方，急性冠症候群の診療における第一選択の心筋マーカーは心筋トロポニン，特に高感度トロポニンである．高感度トロポニン上昇例では，心筋梗塞とそれ以外の病態に起因する心筋傷害との鑑別が不可欠である．
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There has been much interest in improving the accuracy and speed with which chest pain patients presenting to the emergency department are diagnosed and treated. Recently, attention has been directed toward alternative site or point-of-care testing for biochemical markers of myocardial cell necrosis in addition to traditional diagnostic methodologies. The various point-of-care cardiac marker devices available and their potential applications are discussed. Regulatory and quality management issues related of point-of-care testing are reviewed.
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Point-of-Care Testing
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In South Africa, various point-of-care hemoglobin meters are used. However, the regulatory framework for approval, implementation and oversight of use of point-of-care hemoglobin meters is suboptimal. We assessed the diagnostic accuracy of the HemoCue Hb 301, STAT-Site MHgb and URIT-12 point-of-care hemoglobin meters, compared to a central laboratory based reference assay, in a central laboratory and a community based clinic in Durban, South Africa. Differences in performance of the point-of-care assays, compared to the reference assay, were more pronounced in the community based clinic. Results were reasonable for the HemoCue Hb 301, but poor for the STAT-Site MHgb and the URIT-12. Poor test performance of point-of-care hemoglobin meters, and inadequate evaluations and oversight in South Africa, leads to suboptimal clinical care and clinical research, and increased costs. There is a need for proper evaluation and quality assurance of point-of-care tests, the results of which should be made widely available to key stakeholders.
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Abstract The need for routine and immediate healthcare monitoring has inspired “near‐patient testing” or in other words “point‐of‐care testing (POCT)”. Therefore, POCT can be defined as laboratory tests that are performed at the patient's bedside or in the immediate vicinity of the incident. Among many POCTs, nucleic acid‐based testing has attracted enormous attention for the diagnosis of important genetic, inherited and infectious diseases such as cancer and coronavirus. In this review, we outline the integration of nucleic acids into the remarkable electrochemical point‐of‐care diagnostics including microfluidic, paper and smartphone‐based approaches, CRISPR/Cas and liquid biopsy related systems and DNA damage monitoring.
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Point‐of‐care testing of coagulation parameters provides a more rapid assessment of test results compared with laboratory testing. A new coagulation monitor (GEM® PCL, Instrumentation Laboratory, Kirchheim, Germany) was evaluated. Point‐of‐care data for activated partial thromboplastin time and prothrombin time (expressed as the international normalised ratio) and turn‐around‐time were compared. Coagulation parameters were compared in the blood of 57 patients with and without heparin therapy. The point‐of‐care and laboratory test results showed a bias (SD) of − 0.26 (4.55) s for activated partial thromboplastin time and − 0.011 (0.150) s for prothrombin time. The average turn‐around‐time was 3 min for point‐of‐care testing vs. 52 min for laboratory testing. We conclude that the reliability of point‐of‐care testing is sufficient for clinical use.
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Prothrombin time
Coagulation testing
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Point-of-care testing provides current, accurate information relating to thrombosis and hemostasis in patients. Several forces are driving point-of-care testing, particularly economic factors and improved technology. Point-of-care testing has the potential to improve patient management and to decrease integrated costs, although this remains to be shown. For such testing to be successful, the technology must be complemented by hospital-wide point-of-care testing programs. The role of the laboratorian and pathologist will become important for coordinating programs, maintaining quality assurance, and promoting quality improvement.
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Point-of-Care Testing
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Diabetes management
Blood Glucose Self-Monitoring
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PART I. INTRODUCTIONPoint-of-Care Testing in the 21st CenturyGoals and Guidelines for Point-of-Care TestingPrinciples of the Hybrid LaboratoryPrinciples of Anticoagulation and Sample TransportScientific Principles of Point-of-Care Whole-Blood AnalysisDry Reagent Prothrombin Time and Other Hemostasis MethodsImmunoassays for Point-of-Care TestingAdvantages and Disadvantages of Point-of-Care Instruments PART II. POINT-OF-CARE TESTING IN THE HOSPITAL AND CLINICAL PRACTICEPoint-of-Care Hematology, Hemostasis, and Thrombolysis TestingPoint-of-Care Testing in Surgery, Intensive Care, and Cardiopulmonary ResuscitationPoint-of-Care Testing in Emergency MedicineOn-Site Evaluation of Chest Pain Using Biochemical Markers of Myocardial InjuryBedside Testing, Glucose Monitoring, and Diabetes ManagementNursing Strategies for Point-of-Care TestingPoint-of-Care Testing for Infectious DiseasesMolecular Diagnosis at the Point of CarePoint-of-Care Drug TestingPoint-of-Care Testing for Body FluidsEx Vivo and In Vivo Monitoring of Prematures and NeonatesPoint-of-Care Testing in the Children's Hospital PART III. POINT-OF-CARE TESTING IN THE HEALTH SYSTEM, COMMUNITY, AND FIELDPoint-of-Care Testing in Primary Care Networks and Managed CarePoint-of-Care testing in the Veteran's Affairs SystemPoint-of-Care Testing in the Community Health SystemPatient Self-Testing and Self-Management of Oral Anticoagulation with Point-of-Care TestingHome-Based Point-of-Care TestingAdvances in the Physician Office Laboratory PART IV. MANAGEMENT, PERFORMANCE, ACCREDITATION, AND EDUCATIONAssessing Point-of-Care Testing ProgramsQuality Management and Administration of Point-of-Care ProgramsRegulation, Accreditation, and EducationMeeting JCAHO Standards for the Hospital SettingPoint-of-Care Testing and the American College of PathologistsFDA Regulation of Home-Use In Vitro Diagnostic DevicesRegulatory Qualification of New Point-of-Care Diagnostic Devices PART V. INFORMATION, SECURITY, AND KNOWLEDGE SYSTEMSInformatics and Data ManagementInformation Systems for Point-of-Care Testing in Critical CareSecurity, Validation, and ConnectivityThe Role of the Clinical Data Repository in Point-of-Care TestingElectronic Consultation and TelemedicineInternet-Based Disease Management for Home Care and Self-Testing PART VI. ECONOMICS, OUTCOME, AND OPTIMIZATIONBilling for Point-of-Care TestingThe Role of Point-of-Care Testing in Care PathsHealth and Disease Management: The Role of Point-of-Care TestingImproving Economic Outcomes by Algorithmic Diagnosis of Myocardial InfarctionUsing Lactate to Predict Patient OutcomesImproving Medical and Economic Outcomes with Point-of-Care Testing INDE
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