2-ethylhexyl diphenyl phosphate exposure induces duodenal inflammatory injury through oxidative stress in chickens
0
Citation
46
Reference
10
Related Paper
Abstract:
2-ethylhexyl diphenyl phosphate (EHDPHP) is a widely used organophosphorus flame retardant and plasticizer, which is commonly found in the environment. EHDPHP not only potentially harms the environment but also causes different degrees of damage to the organism. In this study, the duodenum of chicks was selected as the potential toxic target organ to explore the mechanism of duodenal injury induced by EHDPHP exposure. Ninety one-day-old healthy male chicks were selected and randomly divided into C1(control group), C2(solvent control group), L(800 mg/kg), M(1600 mg/kg), H(3200 mg/kg) according to different doses of EHDPHP after one week of environmental adaptation. The chicks were given continuous gavage for 14 d, 28 d, and 42 d. It was found that constant exposure to EHDPHP caused an increase in duodenal MDA content, a decrease in P-gp, SOD, GSH-Px activities, and a decrease in duodenal mucosal immune factor (sIgA, GSH-Px). The expression of sIgM and mucosal link proteins (CLDN, OCLN, ZO-1, JAM) decreased, and the expression of the inflammatory protein (NF-κB, COX2) in duodenal tissues was up-regulated. The results showed that continuous exposure to EHDPHP could cause duodenal oxidative stress, inflammation, and mucosal barrier damage in chicks, which provided a basis for studying the mechanism of toxic damage caused by EHDPHP in poultry.During 10 years there were 94 patients aged 16-68 years with injuries of the duodenum. Their case histories were studied in order to establish the causes of complications and lethality. Among them there were 48 patients with knife wounds, 5 patients with gunshot wounds, closed trauma of the abdomen was diagnosed in 40 patients, 1 patient had a iatrogenic wound of the duodenum. There were 17 isolated injuries of the gut and 77 combined and multiple injuries. Patients with traumatic perforations in the duodenum made up 89.4%, 31% of them died. In 70 patients suture of the duodenum was put during operation, 10 patients had sutures and intubation of the duodenum, in 6 patients the injured gut was excluded, in 1 patient resection of the duodenum was made and primary anastomosis was formed. 28 patients (29.8%) died. Among the causes of the deaths were non-compensated blood loss resulting from hemorrhage from the vessels of the liver and other organs, combined and multiple injuries. Pyo-septic complications led to death of 12 patients, duodenal fistula was found in 4 patients. An analysis of the material has shown that most patients with traumas of the duodenum could be cured by suturing the incised or lacerated wound of the duodenum. Exclusion of the duodenum is thought to be a helpful addition to operation on the injured duodenum, especially on large wounds. Pancreatoduodenectomy is necessary but seldom in surgery of such traumas.
Cite
Citations (0)
Objective: To evaluate the diagnostic methods of primary malignant tumors of duodenum. Methods: A retrospective analysis was conducted based on the clinical data of 28 patients with primary malignant tumors of duodenum. Results: Sixteen patients underwent endoscopic examination, 15 of them were positive (93.75%) with the tumors located at upper duodenum and around the papillae. Thirteen patients underwent hypotonic duodenogram and 10 of them were positive (76.92% ), with the tumors located both at upper and lower duodenum. 28 patients underwent ultrasonography, with the positive rate of 53.57% (15/28),all of them being cholangiectasis. Conclusions: Endoscopy was the main method for the diagnosis of tumors located at upper part and around the papillae of the duodenum,and hypotonic duodenogram was effective in the diagnosis of tumors located at lower duodenum.
Cite
Citations (0)
Objective:The purpose of this study is to discuss imaging technique of multi-slice spiral CT and its clinical application value in diagnosis of duodenum diseases.Methods:Nineteen patients with duodenum diseases underwent multi-slice CT image either with gaseous distension or drinking water,and correlated with operative findings and pathology.Using GE Light-speed Ultra 16 slice CT to perform whole duodenum scan in the supine and left decubitus positions.reconstruction images of duodenum were done at the console workstation,including MPR and SSD image.Results:CT images of nineteen patients with duodenum diseases can provide valuable in formation.Drinking water was the basic method of duodenum CT,especially for solid tumor in duodenum,and axial images combined with MPR should be the main technique.Success rate of duodenum imaging with gas is lower.But it is helpful for diagnosis of duodenum diverticulum and differentiated diagnosis between duodenum diverticulitis and malignancy,and SSD combined with MPR should be the main technique.Conclusion:MSCT with post-pressing reformation techniques have great value for diagnosis and differential diagnosis of duodenum diseases.
Supine position
Cite
Citations (0)
Duodenal bulb
Jejunum
Cite
Citations (19)
Brain inflammation and oxidative stress are implicated in certain pathologies such as stroke and Alzheimer's disease, and become more prominent with age and/or metabolic diseases like atherosclerosis. Exercise training has been shown to reduce oxidative stress and inflammation, providing protection in many diseases. We hypothesize that exercise training could improve oxidative stress and inflammation in ApoE −/− mice, specifically in the brain. A 12‐week exercise or sedentary program was enforced in young (8 weeks) and old (66 weeks) ApoE −/− mice on high fat/cholesterol diet. Old mice had significantly higher levels of oxidative stress and a decrease of antioxidant superoxide dismutase in the brain than the young mice. The old exercise trained mice had less oxidative stress and inflammation than the old sedentary mice, as demonstrated by an decrease in MDA, TNFα, NF‐κB, and IL‐1β. Plasma oxidative stress was positively correlated with brain oxidative stress and inflammation. In conclusion, these results suggest that the overall increase in systemic oxidative stress and inflammation inherent in atherosclerosis could lead to further brain oxidative stress and inflammation, which is further exacerbated by aging and a sedentary lifestyle. In addition, the decrease in oxidative stress through exercise training could improve systemic and brain inflammation in this animal model atherosclerosis.
Cite
Citations (1)
The authors report a case of complete rupture of the third duodenum after blind trauma of the abdominal wall. They discuss pre op diagnosis with amount to X ray findings; surgical management included resection of the left part of the 3rd duodenum, 4th duodenum, and 1rst jejunal loop, with latero terminal anastomosis of the lower part of the 2nd duodenum to the jejunum; uneventfull recovery.
Jejunum
Cite
Citations (0)
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUtilization of glutathione during 1,2-dihaloethane metabolism in rat hepatocytesPaul A. Jean and Donald J. ReedCite this: Chem. Res. Toxicol. 1992, 5, 3, 386–391Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://doi.org/10.1021/tx00027a011RIGHTS & PERMISSIONSArticle Views73Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-Alerts Get e-Alerts
Glutathione reductase
Glutathione S-transferase
Cite
Citations (26)
PM2.5 exposure exacerbates cardiovascular diseases via oxidative stress and inflammation, the detailed mechanism of which is unclear. In this study, the effects of oxidative stress and inflammation, as well as vascular structure and function were studied by multiple PM2.5 exposure model of ApoE-/- mice. The results indicated that NO produced by iNOS not cNOS might play important roles in inducing vascular dysfunction after PM2.5 exposure. The occurrence order and causality among NO, other oxidative stress indicators and inflammation is explored by single PM2.5 exposure. The results showed that NO generated by iNOS occurred earlier than that of other oxidative stress indicators, which was followed by the increased inflammation. Inhibition of NOS could effectively block the raise of NO, oxidative stress and inflammation after PM2.5 exposure. All in all, we firstly confirmed that NO was the initiation factor of PM2.5 exposure-induced oxidative stress, which led to inflammation and the following vascular dysfunction.
Endothelial Dysfunction
Cite
Citations (31)
Long before the Christian era, the duodenum was named and its function in controlling gastric emptying was conjectured. It received almost no further attention until the Eighteenth century when its relation to the bile and pancreatic ducts became know. The embryogenesis of the duodenum and the histological features of the organ are described as well as the gross movements that explain the mature relations of the duodenum to the surrounding structures. The "sphincters" of the duodenum are mentioned and evaluated.
Cite
Citations (2)
Four cases of involvement of the duodenum by metastases arising from tumours of the reproductive organs have been reported. The mode of spread of tumours to the duodenum is described. The differential diagnosis of radiological changes in the duodenum and the management of patients with metastatic involvement of the duodenum have been briefly discussed.
Genital tract
Cite
Citations (17)