Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer
Zitian HuoYaqi DuanDongdong ZhanXizhen XuNairen ZhengJing CaiRuifang SunJianping WangFang Qin ChengZhan GaoCaixia XuWanlin LiuYuting DongSailong MaQian ZhangYiyun ZhengLiping LouDong KuangQian ChuJun QinGuoping WangYi Wang
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Abstract:
Small cell lung cancer (SCLC) is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models. Here, we analyzed formalin-fixed, paraffin-embedded (FFPE) samples of surgical resections by proteomic profiling, and stratified SCLC into three proteomic subtypes (S-I, S-II, and S-III) with distinct clinical outcomes and chemotherapy responses. The proteomic subtyping was an independent prognostic factor and performed better than current tumor-node-metastasis or Veterans Administration Lung Study Group staging methods. The subtyping results could be further validated using FFPE biopsy samples from an independent cohort, extending the analysis to both surgical and biopsy samples. The signatures of the S-II subtype in particular suggested potential benefits from immunotherapy. Differentially overexpressed proteins in S-III, the worst prognostic subtype, allowed us to nominate potential therapeutic targets, indicating that patient selection may bring new hope for previously failed clinical trials. Finally, analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line immunotherapy. Collectively, our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.Keywords:
Risk Stratification
Stratification (seeds)
This chapter contains sections titled: Epidemiological impact of risk stratification The Bayesian approach to the impact of the changing prognosis upon tests used for risk stratification Risk stratification in postinfarction patients Risk stratification in nonischemic cardiomyopathy Summary References
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The purpose of this research was to explore the ripening seeds of the wild hawthorn,such as Altai hawthorn,Junggar Hawthorn and crabapple hawthern,which were treated with different stratification including,wet-seed constant temperature stratification,temperature change stratification,normone immersion processing,the stratification method after drying.The result showed that temperature change stratification could promote the germination rate of the two hawthern seeds but there were differences in time range of better suitable stratification needed for different hawthorn seeds,the germination rate of the seeds of Altai hawthorn can reach 39.5% when the stratification for 90d;The germination rate of the seed of the crabapple hawthorn can reach 27.1% when the stratification for 150d.The germination rate of Junggar hawthorn seed was relatively low,the germination rate was only 10.2%after the treatment of 100mg/L of GA3 and the stratification for 180d.Different stratification can break the dormancy and promote germination rate of wild hawthorn seed,and the effect of processing of variable temperature stratification is better. The seed of Altai hawthorn has the higher germination rate.
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