Radiomics-Based Ultrasound Model For Differentiating Uterine Sarcomas From Leiomyomas: The ROMUS Study In The MITO Group
Francesca CiccaroneAlessandro RizziAntonella BiscioneTina PasciutoLuca BoldriniHuong Elena TranGiulia BaldassariFulvio BorellaF. BuonomoAnila KardhashiJvan CasarinL. ValentinDomenica LorussoGiovanni ScambiaAntonia Carla Testa
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Uterine Leiomyoma
Uterine Leiomyoma
Breakpoint
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Objective To explore the correlation between uterine leiomyoma and plasma concentration of hydrogen sulfide( H2S). Methods 400 women whose the adnexauteri were ckecked by type B ultrasound in our hospital were selected into our study. The concentration of plasmic H2 S was tested by the spectrophotography. The difference between the patients with uterine leiomyoma and the healthy group without uterine leiomyoma was compared. The correlation between the concentration of plasmic H2 S and the related risk factors of uterine leiomyomas including the age,family history of uterine leiomyoma,cervical erosion,oral contraceptive medication and repeated abortion et al was analyzed by Pearson test. Results Compared with the healthy group without uterine leiomyoma,the concentration of plasmic H2 S in the patients with uterine leiomyoma was significantly decreased( P 0. 05). The concentration of plasmic H2 S in the patients with uterine leiomyoma was negatively correlated with the quantity of uterine leiomyomas,the maximum diameter of uterine leiomyoma,and the related risk factors of uterine leiomyomas including the age,family history of uterine leiomyoma,cervical erosion,oral contraceptive medication and repeated abortion( all P 0. 05). Conclusion The concentration of plasmic H2 S in the patients with uterine leiomyoma was decreased and the decrease of the concentration of plasmic H2 S in the patients with uterine leiomyoma is negatively correlated with the occurrence and development of uterine leiomyoma.
Uterine Leiomyoma
Etiology
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Objective To investigate the clinical and histological characteristics of cellular uterine leiomyoma.Methods The records of 55 patients with uterine cellular leiomyoma(research group) and 120 patients with normal leiomyoma(control group) were reviewed and analyzed,who were admitted to our hospital from February,1998 to April 2005.Results The average age of the research group was 33.8 and younger than the control group.The growth speed of the cellular leiomyoma was faster than the normal leiomyoma,and was prone to growing into the round ligaments.The texture of the cellular leiomyoma was less hard than normal.The leiomyoma of the research group was bigger and bleeding more during operation than the control group.Three cases recurred and 5 were pregnant during follow-up.Conclusions The characteristics of uterine cellular leiomyoma are prevalent at young age,growing fast,large bulk,relatively soft and prone to bleeding during operation.Uterine cellular leiomyoma must be followed up carefully.
Uterine Leiomyoma
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Background: Uterine artery embolization (UAE) is one of the minimally-invasive alternatives to hysterectomy for treatment of uterine leiomyomas. There are various factors affecting the outcomes of UAE, but these have only been sporadically studied. Study Objective: To identify factors associated with the efficacy of UAE for the treatment of uterine leiomyoma, and to develop a model for the prediction of treatment response of uterine leiomyomas to UAE. Study design: A retrospective cohort study (Canadian Task Force Classification II-2) Patients: One hundred ninety-eight patients with symptomatic uterine leiomyomas. Intervention: UAE Measurements and Main Results: Among 198 leiomyoma patients who were treated with UAE, 104 who underwent pelvic magnetic resonance imaging (MRI) with diffusion-weighted imaging were selected for developing prediction model. Variables that were statistically significant from the univariate analysis were: location of leiomyoma, total number of lesions, sum of leiomyomas diameters, T2 signal intensity of largest leiomyoma, and T2 leiomyoma:muscle ratio. After a logistic regression analysis, leiomyoma location and T2 signal intensity of the largest leiomyoma were found to be statistically significant variables. Using intramural myomas defined as controls, submucosal leiomyomas showed a greater response to UAE with an odds ratio of 7.6904. The odds ratio of T2 signal intensity with an increase in signal intensity of 10 was 1.093. Using these two variables, we developed a prediction model. The AUC in the prediction model was 0.833, and the AUC in the validation set was 0.791. Conclusion: We identified that submucosal leiomyomas and those leiomyomas that show high signal intensity on T2-weighted imaging will exhibit a greater response to UAE. Prediction models are clinically helpful in selecting UAE as an appropriate treatment option for managing uterine leiomyoma.
Uterine Leiomyoma
Uterine Artery Embolization
Uterine Fibroids
Univariate analysis
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Background: Uterine mesenchymal tumours are a heterogeneous group of neoplasms that can frequently be diagnostically challenging. Most subtypes of leiomyoma are chiefly of interest in that they mimic malignancy in one or more respects. Objective: To evaluate the histomorphological features of uterine leiomyomas and its variants. Materials and methods: Total of 477 cases of uterine leiomyomas and its variants were analysed prospectively in a period of 2years during July 2010 to June 2012 to assess the various pattern of leiomyomas. Cases were studied in detail about complete history, clinical examination and other findings. Results: In the study 468 (98.11%) cases showed features of conventional leiomyoma and 8 cases showed variants of leiomyomas (1.68%). Conclusion: Although their diagnosis is straight forward in most cases, difficulties arise with particular leiomyoma variants, especially highly cellular leiomyoma (often confused with an endometrial stromal tumour) and leiomyoma with bizarre nuclei, mitotically active leiomyoma which may cause concern for leiomyosarcoma.
Uterine Leiomyoma
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Objective To detect the change of insulin-like growth factor binding protein-3(IGFBP-3) in serum and leiomyoma tissue of patients with uterine leiomyoma. Methods The serum IGFBP-3 from 60 cases of uterine leiomyoma and 60 cases healthy women was tested by ELISA,the IGFBP-3 leiomyoma tissue and myometrium tissue from the 60 cases uterine leiomyoma was tested by immunohistochemistry. Results In patients with uterine leiomyoma,the serum IGFBP-3 was significantly lower than that in healthy women,the IGFBP-3 in leiomyoma tissue was significantly weaker than that of normal myometrium,P0.01. Conclusion The IGFBP-3 in both serum and leiomyoma tissue are lower in patients with uterine leiomyoma,which suggests that IGFBP-3 play important role in the occurrence,development of uterine leiomyoma.
Myometrium
Uterine Leiomyoma
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Uterine Leiomyoma
HMGA2
SNP array
SNP
Smooth Muscle Tumor
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This study was conducted to examine the correlation between uterine vascularity and natural history of uterine leiomyoma. Seventy women with leiomyoma participated in this study. Measurements of uterine and leiomyoma volume, as well as blood flow characteristics of the main uterine artery and leiomyoma arteries, were made every 3 months for 1 year. Leiomyoma arteries could be detected in 52 (51.5%) of 101 leiomyomas. Leiomyoma volume increased in 24 (46.2%) of 52 leiomyomas with leiomyoma artery. However, the leiomyoma volume increased in only three (6.1%) of 49 leiomyomas without leiomyoma artery. No difference was found between the pulsatility index of the leiomyoma artery in the group with increased size and in the group with stable size. This study shows the vascularity of leiomyoma to be useful as a predictor of leiomyoma growth.
Uterine Leiomyoma
Vascularity
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Abstract Background Uterine leiomyomas are hormone-dependent benign tumors and often begin to shrink after menopause due to the reduction in ovarian steroids. The influence of pregnancy on uterine leiomyomas size remains unclear. Here, we present a case of spontaneous regression of a giant uterine leiomyoma after delivery. Case presentation A 40-year-old woman presented with multiple uterine leiomyomas, one of which is a giant uterine leiomyomas (approximately 8 cm in diameter) that gradually shrinked after delivery. At over two months postpartum, the large myometrial leiomyoma had transformed into a submucosal leiomyoma, and over 3 years postpartum, both the submucosal leiomyoma and multiple intramural leiomyomas completely regressed. Conclusion Spontaneous regression of a giant uterine leiomyom is rare after delivery. Considering uterine leiomyoma regression until over 3 year postpartum,we need to observe the regression of uterine fibroid for a longer time postpartum in the absence of fibroid related complications. In addition, it will provide new insights for treatment options of uterine leiomyomas in the future.
Uterine Leiomyoma
Uterine Fibroids
Uterine rupture
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Uterine Leiomyoma
Fluorodeoxyglucose
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