The neuropsychological profile of SSADH deficiency, a neurotransmitter disorder of GABA metabolism
Itay Tokatly LatzerEllen HansonMariarita BertoldiMelissa L. DiBaccoDeniz AygunOnur AfacanÀngels García‐CazorlaNatalia Juliá‐PalaciosThomas OpladenOya Kuseyri HübschmannKathrin JeltschPetra AdenMari OppebøenAlexander RotenbergMelissa TsuboyamaJean‐Baptiste RoulletPhillip L. Pearl
0
Citation
45
Reference
10
Related Paper
Keywords:
Neurotransmitter Systems
A case‐control study involving children born between 1997 and 2007 has concluded that prenatal exposure to most of the medications that affect neurotransmitter systems is not associated with risk of autism spectrum disorder (ASD) in children. The study employed a novel strategy that grouped medications into classes based on their target neurotransmitter, thus grouping together some drugs regardless of the various medical indications for which they were being used. Study results were published online Oct. 31 in JAMA Psychiatry .
Neurotransmitter Systems
Affect
Neurotransmitter receptor
Cite
Citations (0)
Neurohormones
Neurotransmitter Systems
Cite
Citations (0)
Objective To find the growth rules and trends of neurotransmitter-related papers covered in PubMed in order to provide evidence for neurotransmitter-related projects.Methods Neurotransmitter-related papers with their sources covered in PubMed from 1947-01-01 to 2008-12-31 were retrieved using neurotransmitter as a
Neurotransmitter Systems
Neurotransmitter Agents
Neurotransmitter receptor
Cite
Citations (0)
Objective:To investigate neurotransmitter activation in patients with chronic insomnia.Methods:Encephalofluctuogram(EFG)were obtained from 51 patients with chronic insomnia and 51 healthy individuals, Parameters of EFG that reflect neurotransmitter activation were analysed.Results:S1 and S2 of neurotransmitter list in EFG are obviously lowered in patients with chronic insomnia compared with healthy individuals.Conclusions:Neurotransmitter GABA(S1) and Glu(S2) may be involved in the patients with chronic insomnia.
Neurotransmitter Systems
Chronic Insomnia
Cite
Citations (0)
A rational basis for the psychopharmacologic management of behavioral disturbances after head trauma has been presented that is predicated on research in neurotransmitter changes that evolve subsequent to head trauma. The paucity of human studies in this area mandates the use of experimental models and evidence garnered from provocative challenges to suggest the underlying neurotransmitter profile in various behavioral abnormalities. Multiple neurotransmitter circuits exist that provide parallel, duplicate, and redundant systems for these behaviors. Certainly, alternative explanations could be offered for the examples cited above. Furthermore, measurement of neurotransmitter metabolite concentration in cerebrospinal fluid does not allow specific inferences to be made regarding topographic correlation and neurotransmitter function. Nor does it afford assessment of regional differences in psychotropic influence on neurotransmitter receptors. New imaging techniques (eg, positron emission tomography) will certainly aid in this determination. Current investigations, however, support the concept that neurotransmitter changes do occur after head injury, that these alterations exist during the time that "recovery" occurs, and that psychotropic agents influence this recovery process. Further research is needed to clarify neurotransmitter changes after head injury and to identify psychotropic intervention strategies that facilitate the recovery process.
Neurotransmitter Systems
Neurotransmitter receptor
Neurotransmitter Agents
Cite
Citations (5)
The past decade has witnessed a tremendous increase in knowledge towards understanding the function of various brain neurotransmitter substances in behavior. Experimental observations in animals, utilizing specific pharmacological agents, have enabled the development of certain hypotheses regarding neurochemical substrates of behavior. These have led to cautious applications of complementary studies in humans. As a result, several neurotransmitter-related hypotheses have been developed for the explanation of normal behaviour, as well as of various abnormal behavior states in psychiatry and neurology. These hypotheses are currently undergoing extensive investigation. Highlights of the above sequence of events are presented, in order to provide as general, yet extensive, an overview of the subject as possible. Examples are provided from both basic laboratory investigations and from clinical findings. Principles of brain neurotransmitter function and interactions are reviewed. Various neurotransmitter-related hypothese of psychiatric and neurologic interest are introduced. Finally, the role that toxicants may have on behavior via alteration of brain neurotransmitter function is discussed, using the lead intoxicated animals as an illustrative example.
Neurochemical
Neurotransmitter Systems
Neurotransmitter Agents
Brain Function
Neurochemistry
Cite
Citations (0)
The past decade has witnessed a tremendous increase in knowledge towards understanding the function of various brain neurotransmitter substances in behavior. Experimental observations in animals, utilizing specific pharmacological agents, have enabled the development of certain hypotheses regarding neurochemical substrates of behavior. These have led to cautious applications of complementary studies in humans. As a result, several neurotransmitter-related hypotheses have been developed for the explanation of normal behaviour, as well as of various abnormal behavior states in psychiatry and neurology. These hypotheses are currently undergoing extensive investigation. Highlights of the above sequence of events are presented, in order to provide as general, yet extensive, an overview of the subject as possible. Examples are provided from both basic laboratory investigations and from clinical findings. Principles of brain neurotransmitter function and interactions are reviewed. Various neurotransmitter-related hypothese of psychiatric and neurologic interest are introduced. Finally, the role that toxicants may have on behavior via alteration of brain neurotransmitter function is discussed, using the lead intoxicated animals as an illustrative example.
Neurochemical
Neurotransmitter Systems
Neurotransmitter Agents
Brain Function
Neurochemistry
Cite
Citations (10)
All drugs in psychiatry act by influences on neurotransmitter systems. Hence, an appreciation of neurotransmitter disposition helps clarify our understanding of therapeutic actions as well as adverse effects of psychotropic drugs. Moreover, understanding the nuances of neurotransmitters facilitates efforts to develop novel agents. Currently available psychoactive drugs exert their effects through 3 or 4 of the longest-known neurotransmitters. Over the past few decades, up to 100 novel neurotransmitter candidates have been identified, each of them as interesting as traditional biogenic amines. It is likely that totally new classes of therapeutic agents will emerge based on these transmitter molecules.
Neurotransmitter Systems
Neurotransmitter Agents
Neurotransmitter receptor
Cite
Citations (19)
Positron emission tomography is a medical imaging technique that provides unique information concerning many biochemical mechanisms underlying normal physiologic function. With respect to the central nervous system (CNS), selective radiolabeled compounds targeted at specific neurotransmitter receptor systems reveal information not only concerning receptor distribution and enzymatic activity but neurotransmitter concentrations as well. Recent advances in our understanding of these systems may be utilized to further understand changes in brain biochemistry that either result from or produce symptomatology associated with many CNS disease states. The ability to measure interactions between neurotransmitter systems in the human brain may also add to our knowledge of drug side effects and disease progression. While many CNS diseases have been defined as "neurotransmitter-specific" in nature, scientific data now suggests that changes in multiple neurotransmitter systems are evident in the brains of patients suffering from these classically described diseases. PET is a powerful tool that can be used to examine many of these changes in the living human brain.
Neurotransmitter Systems
Neurotransmitter receptor
Neurotransmitter Agents
Human brain
Cite
Citations (1)
Measuring and manipulating neurotransmitter function in man. Methods for determining the possible malfunction of a particular neurotransmitter in a CNS disorder are described and evaluated. These include measuring the levels of the neurotransmitter or its metabolites in body fluids, those levels or the number of its receptors in PM brain tissue and brain imaging with particular reference to PET. Animal models in which the equivalent of a human disorder has been produced by lesions, pharmacological manipulation of neurotransmitter or genetic breeding are also considered. The approaches by which alterations in the synthesis, storage, release, actions and destruction of a particular neurotransmitter can be achieved to therapeutic advantage in man are then critically analysed and the conditions under which such approaches could be successful are considered.
Neurotransmitter Systems
Neurotransmitter receptor
Neurotransmitter Agents
Brain Function
Cite
Citations (1)