Figure S11 from RNA-encoded Interleukin 2 with Extended Bioavailability Amplifies RNA Vaccine–Induced Antitumor T-cell Immunity
Daniel PetersLena M. KranzDavid EiselMustafa DikenSebastian KreiterÖzlem TüreciUğur ŞahinMathias Vormehr
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<p>Representative dot plots corresponding to flow cytometry data displayed in Figure 6.</p>Keywords:
Cell mediated immunity
The continuous effect of radiocobalt (Co/sup 60/) on cell immunity was studied. The data show that chronic irradiation in low doses disturbs cell immunity. Confrontation of disturbances of the humoral and cell immunity divulged that they occur simultaneously in the irradiated organism. The phase of inhibition is preceded by the phase of stimulation. (auth)
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Cell mediated immunity
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The recently acquired knowledge of the importance of cell-mediated immunity in many illnesses and the discovery of a variety of substances that can restore certain cell-mediated immune functions has served to focus the attention of physicians on this area of immunity. It is important for practicing physicians to have a clear understanding of current knowledge of the role of cell-mediated immunity in resistance to infection and how this arm of the immune system relates to the diagnosis and therapy of infectious diseases.
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Cell mediated immunity
Marek's disease
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This paper presents a review of 123 cases of leprosy of different clinical types as regards to their status of cellular immunity. These 123 cases included 41 fresh cases, 18 cases of reaction and 64 cases of leprosy taking antileprosy treatment. Out of 41 untreated cases only 11 turned up for follow up and their lymphoblastic transformation was repeated 4 to 6 months after initiating the treatment. It was observed that cell mediated immunity as expressed in terms of percentage of blast cells is definitely depressed in leprosy, most in LL and least in TT. There is a definite increase in the percentage of blast cells after taking antileprosy treatment. The rise in percentage of blast cells and hence cellular immunity is relatively more in patients treated with Lamprene as compared to those treated with DDS. Reactions also have impact over immunity in leprosy. Thus, most of the patients with ENL show higher values for blast percentage as compared to those with lepra reaction. It appears that serial lymphocyte cultures if done in all cases of leprosy undergoing treatment will help in assessment of individual progress.
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Mycobacterium leprae
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ABSTRACT: The role of cell‐mediated immunity (CMI) in wart infection was demonstrated. The correlation with humoral immunity was also suggested. Patients with cell‐mediated immune deficiency were found to be more susceptible to wart infection than those with humoral immune deficiency.
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Experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of Nocardia asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.
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Objective:To observe the effect of compound decotion Caiyu on the immunity system of immunity hepatic damage mice.Methods:72 mice were randomly divided intonormal group,model group,control group and three therapy groups.The model of immunity heaptic damage were made by injecting BCG+LPS.ALT active unit in serum,activity of NK cell,percentage of CD+3、CD+4、CD+8 and CD+4/CD+8 of every group were determinated.Results:Percentage of CD+3、CD+4 cell and CD+4/CD+8 and activity of NK cell of three therapy groups was obviously higher than that of model group.Conclusion:Ddecoction Caiyu can strengthen the T-cell immunity function of the mice and adjust the net of the T-cell immunity,also strengthen the NK cell activity.
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Cellular immunity to Chlamydia trachomatis is not well understood. Studies with the mouse pneumonitis agent in a mouse pneumonia model suggest a strong thymic component to immunity and a role for the macrophage as an effector cell in cell-mediated immunity to C. trachomatis. Experiments with Chlamydia psittaci indicate that cellular cytotoxic mechanisms and biostatic or cytotoxic mechanisms involving cytokines may also play a role in host defense against chlamydiae. Interferon has been shown to inhibit intracellular growth of both C. trachomatis and C. psittaci in vitro. Further studies are needed on the role of T lymphocytes or lymphokines and macrophages in limiting the growth of C. trachomatis in conjunctival epithelial cells (the most appropriate target cells) and in exerting a toxic effect on these cells. The evidence suggests that macrophages are activated during C. trachomatis infection; this activation may lead to the release of monokines (such as interleukin 1) that may be important in the pathogenesis of scarring due to over-stimulation of cellular immunity during ocular infection. Cell-mediated immunity to ocular infection with C. trachomatis may thus be a double-edged sword.
Chlamydial infection
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Experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of Nocardia asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.
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Delayed hypersensitivity
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