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    Distinct Mechanisms for Activation of the Opioid Receptor-Like 1 and κ-Opioid Receptors by Nociceptin and Dynorphin A
    Molecular Pharmacology (1999)
    Catherine MollereauLionel MoulédousSophie LapaluGilles CamboisChristiane MoisandJean‐Luc ButourJean-Claude Meunier
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    39
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    10
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    Keywords:
    Nociceptin receptor
    Dynorphin
    Dynorphin A
    Topics:
    Neuropeptides and Animal Physiology
    Receptor Mechanisms and Signaling
    Hypothalamic control of reproductive hormones
    Regulation of Opioid Receptors by Their Endogenous Opioid Peptides
    Cellular and Molecular Neurobiology (2021)
    Achla GuptaSrinivas GullapalliHui‐Lin PanDinah L. Ramos‐OrtolazaMichael D. Hayward
    Proenkephalin
    Dynorphin
    Endogenous opioid
    Dynorphin A
    Proopiomelanocortin
    Citations (19)
    Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain
    Addiction Biology (2011)
    Claudio D’AddarioFrancesca Felicia CaputiRoberto RimondiniOttavio GandolfiE. Del Borrello
    Molecular mechanisms of adaptive transformations caused by alcohol exposure on opioid dynorphin and nociceptin systems have been investigated in the rat brain. Alcohol was intragastrically administered to rats to resemble human drinking with several hours of exposure: water or alcohol (20% in water) at a dose of 1.5 g/kg three times daily for 1 or 5 days. The development of tolerance and dependence were recorded daily. Brains were dissected 30 minutes (1- and 5-day groups) or 1, 3 or 7 days after the last administration for the three other 5-day groups (groups under withdrawal). Specific alterations in opioid genes expression were ascertained. In the amygdala, an up-regulation of prodynorphin and pronociceptin was observed in the 1-day group; moreover, pronociceptin and the kappa opioid receptor mRNAs in the 5-day group and both peptide precursors in the 1-day withdrawal group were also up-regulated. In the prefrontal cortex, an increase in prodynorhin expression in the 1-day group was detected. These data indicate a relevant role of the dynorphinergic system in the negative hedonic states associated with multiple alcohol exposure. The pattern of alterations observed for the nociceptin system appears to be consistent with its role of functional antagonism towards the actions of ethanol associated with other opioid peptides. Our findings could help to the understanding of how alcohol differentially affects the opioid systems in the brain and also suggest the dynorphin and nociceptin systems as possible targets for the treatment and/or prevention of alcohol dependence.
    Nociceptin receptor
    Dynorphin
    κ-opioid receptor
    Dynorphin A
    Self-administration
    Citations (69)
    Solution Conformation of Nociceptin
    Biochemical and Biophysical Research Communications (1997)
    Severo SalvadoriDelia PiconeTeodorico TancrediRemo GuerriniRoberta Spadaccini
    Nociceptin receptor
    Dynorphin
    Dynorphin A
    Citations (24)
    Role of nociceptin/orphanin FQ and the pseudopeptide [Phe1Ψ(CH2NH)Gly2]-nociceptin(1–13)-NH2 and their interaction with classic opioids in the modulation of thermonociception in the land snail Helix aspersa
    European Journal of Pharmacology (2007)
    Carolina Miller-PérezEduardo Sánchez-IslasFrancisco PellicerGabriela Rodrı́guez–ManzoSilvia L. Cruz
    Nociceptin receptor
    Dynorphin
    NOP
    Dynorphin A
    Citations (11)
    A non-opioid pattern characterizes inhibition of growth hormone releasing peptide binding by dynorphin-related peptides
    Neuropeptides (1990)
    E E CoddVincent J. AloyoRichard F. Walker
    Dynorphin
    Dynorphin A
    Citations (7)
    Evidence for the expression of peptides derived from three opioid precursors in NG 108CC15 hybrid cells
    Neuropeptides (1987)
    Thomas DandekarRüdiger Schulz
    Dynorphin
    Dynorphin A
    Proopiomelanocortin
    Endorphins
    beta-Endorphin
    Alpha (finance)
    Citations (1)
    Author Index for Volume 305
    Archives of Biochemistry and Biophysics (1993)
    Nociceptin receptor
    Dynorphin
    Dynorphin A
    Citations (0)
    Dynorphin/α-Neo-endorphin
    Elsevier eBooks (2015)
    Akiyoshi Takahashi
    Dynorphin
    Dynorphin A
    Pentapeptide repeat
    Endorphins
    Endogenous opioid
    Citations (1)
    Dynorphin/α-neo-endorphin
    Elsevier eBooks (2021)
    Akiyoshi Takahashi
    Dynorphin
    Dynorphin A
    Pentapeptide repeat
    Endorphins
    Endogenous opioid
    Citations (0)
    Central non-opioid physiological and pathophysiological effects of dynorphin A and related peptides.
    PubMed (1992)
    Vijay K. ShuklaStéphane D. Lemaire
    Dynorphin A (Dyn A) and related opioid peptides derived from prodynorphin possess a high affinity for kappa opioid receptors, but they also bind to other opioid receptors (mu and delta) as well as to some non-opioid receptor sites. Although the physiological role of these peptides is not well established, recent experimental data pinpoint their particular involvement in physiological and pathophysiological conditions that relate to algesia, spinal cord injury and epilepsy. In this paper, we review data which support the concept that the non-opioid behavioral effects of Dyn A and related endogenous peptides which are observed under these conditions are physiologically and pathophysiologically relevant.
    Dynorphin
    Dynorphin A
    κ-opioid receptor
    Pathophysiology
    Endogenous opioid
    δ-opioid receptor
    Citations (19)