Long-term efficacy and anamnestic response of hepatitis B vaccine derived from Chinese hamster ovary cell after 18–20 years
Qiudong SuFeng QiuZhao GaoYuliang ZhaoJingchen MaZhi-Yong HaoShuang ZhangLiping ShenShengli BiFeng WangHaisong Zhou
0
Citation
31
Reference
10
Related Paper
Keywords:
Hepatitis B vaccine
Hepatitis B
Objective To study the immune efficacy and safety of 10μg and 5μg hepatitis B vaccine in newborns and to provide the scientific basis for the adjustment of neonatal hepatitis B vaccine immunization programs. Methods The HBV antibody levels of people who inoculated various doses of hepatitis B vaccine in different time were observed when they were born with case-control study method. Serum antibody levels were detected by chemiluminescence immunoassay. Results 1 month, 6 months and 12 months after full course of inoculation of hepatitis B vaccine, non-response rate in 10μg hepatitis B vaccine was higher than that of 5μg hepatitis B vaccination group. The titer of HBsAb in 10μg hepatitis B vaccine group was higher than that of 5μg hepatitis B vaccination group. 12 months after inoculation, the titer of HBsAb in two groups were both reduced, and the positive rate of HBsAb in10μg hepatitis B vaccine group was higher than that of 5μg hepatitis B vaccination group. Conclusion The efficacy of 10μg hepatitis B vaccine group is better than that of 5μg hepatitis B vaccine group.
Hepatitis B vaccine
Hepatitis B
Hepatitis A vaccine
Group B
Cite
Citations (0)
Objective To investigate the vaccination rate of hepatitis B vaccine,HBV infection rate and the antibody-positive rate among the children to enter the kindergarten in the urban area of Lishui city,Zhejiang province,and provide the evidence for the improvement of the prevention and control of hepatitis B.MethodsDuring 2006-2008,peripheral blood samples were collected from 10 619 children(4052 in 2006,4420 in 2007,2147 in 2008) at the entrance physical examination to detect HBsAg and anti-HBs by using ELISA.The children's vaccination records were reviewed to know their hepatitis B vaccination status.ResultsThe vaccination rate of hepatitis B vaccine among these children was 99%,and the overall positive rate of HBsAg was 0.56% with 0.71% for 2006,0.52% for 2007 and 0.37% for 2008 respectively,indicating a decreasing trend(P0.05).The overall positive rate of anti-HBs was 47.10% with 42.57% for 2006,48.21% for 2007 and 53.38% for 2008 respectively,indicating an increasing trend(P0.01).ConclusionThe vaccination rate of hepatitis B vaccine was high,HBV infection rate was low and anti-HBs positive rate increased year by year among the children to enter the kindergartens in Lishui city,which indicating that achievement had been made on the control and prevention of hepatitis B among the children in Lishui.
Hepatitis B vaccine
Hepatitis B
Cite
Citations (0)
Objective To understand the rural and urban women of childbearing age in Huainan City,Hepatitis B vaccination and hepatitis B prevention awareness,investigate the immune status of hepatitis B virus,hepatitis B prevention for women of childbearing age provide a reference.Methods The vaccine for hepatitis B and hepatitis B prevention and treatment of cognitive level of the survey and testing were surveyed in serum markers of hepatitis B,statistics of hepatitis B infection and immunity levels.Results The women of childbearing age with hepatitis B vaccine inoculation rate of 38.49 percent on average.Of hepatitis B prevention and control higher cognitive level,the higher rate of hepatitis B vaccination.An average of 6.29% positive rate of HBsAg,hepatitis B vaccine in vaccinated than unvaccinated HBsAg-positive hepatitis B vaccine (2.51% vs8.66%),the difference was significant P0.05.HBsAb positive rate of 46.73%.Hepatitis B vaccination rate and HBsAb positive rate was positively correlated.HBsAb hepatitis B vaccine in vaccinated than unvaccinated positive for hepatitis B vaccine (77.67%%vs27.36%),the difference was significant P0.05,with 22.32 percent had been vaccinated with hepatitis B vaccine were HBsAb negative.Conclusion The city women of childbearing age the rate of hepatitis B immune protection is not high,are more susceptible to hepatitis B epidemic prevention work is far from the intended purpose.Expand the implementation of the hepatitis B vaccine immunization programs,to develop a more comprehensive prevention strategy HBV vaccine is imperative.
Hepatitis B vaccine
Hepatitis B
Hepatitis A vaccine
Cite
Citations (0)
Hepatitis B vaccine
Hepatitis B
Seroconversion
Group B
HBeAg
Cite
Citations (11)
Hepatitis B has been become a cosmopolitan public healthy problem. Hepatitis B vaccine was the leading measure for prevention of hepatitis B. The application of hepatitis B vaccine on preventing mother-infant transmission, child and adult immune, administration of non-and low-responder of hepatitis B vaccine were surveied. Future strategy of hepatitis B vaccine was also discussed.
Hepatitis B vaccine
Hepatitis B
Cite
Citations (0)
Objective To describe the current HBV incidence and epidemiology among children born by women suffering from hepatitis B.Methods Newborns were injected hepatitis B vaccine,and one month and six months later were injected hepatitis B Vaccine repeatly.Six years later fresh serum samples of the children were analyzed by ELISA.Results The HBsAg rate among children not received hepatitis B vaccine was 90%(9/10),the HBsAb rate was 10%(1/10).And the HBsAg rate among children received hepatitis B vaccine was 5%(1/20),while the HBsAb rate was 80%(16/20).Conclusion The HBsAg rate is lower among children received hepatitis B vaccine than those not received hepatitis B vaccine .
Hepatitis B vaccine
Hepatitis B
Cite
Citations (0)
Objective To understand the protective effects of children after hepatitis B vaccine immunization since 1992,when the hepatitis B vaccine into childhood immunization strategy .Methods Hospitalized children from venous blood,using enzyme-linked immunosorbent assay（ELISA）,to investigate and analyze the immune status based hepatitis B immune of hospitalized children （Infection,Pediatric）,by five indicators of hepatitis B as the judgment standard.Results The total anti-HBs-positive rate was 55.05%,including infection anti-HBs-positive rate 52.18%, the pediatric anti-HBs-positive rate 55.92%.Male anti-HBs positive rate was 54.17%,the female anti-HBs positive rate was 56.6%,there was no statistical significance among departments and sexs （P〉0.05）.Conclusion Hepatitis B vaccination is the effective control means for hepatitis B ,however,the anti-HBs positive rate is low in this region after hepatitis B vaccine immunization ,needed to reseed .
Key words:
Hepatitis B vaccines; Immunity; Child
Hepatitis B vaccine
Hepatitis B
Cite
Citations (0)
Background: The widely recommended standard schedule of hepatitis B vaccine for adults is months 0, 1 and 6, which takes 6 months to complete. Rapid completion of one vaccination schedule is important to adults because of its low compliance with follow-up doses. A new type of 60 μg Hepatitis B vaccine, made by Shenzhen Kangtai Biological Products Co., LTD., is originally recommended for low or non-responders. The objective of this clinical trial was to test whether this 60 μg hepatitis B vaccine could be used in primary immune population and what is its level of immunogenicity and safety compared with other hepatitis B vaccines.Methods: This is a 2-center randomized controlled study. A total of 1169 healthy adults aged between 25 and 55 who tested negative for HBsAg, anti-HBs, and anti-HBc were eligible for the study and were enrolled from relatively fixed and stable sites, such as villages, schools and large enterprises et al in Xuanhua county in Hebei province and Huaibei county in Anhui province. They were randomized to group A (20 μg Engerix-B® with 0, 1, 6 month intervals), group B (20 μg Kangtai hepatitis B vaccine with 0, 1, 6 month intervals), group C (60 μg Kangtai hepatitis B vaccine with 0, 2 month intervals) and group D (20 μg Huabei hepatitis B vaccine made by recombinant DNA techniques in CHO cell with 0, 1, 6 month intervals). In group A, B and D, every study object's blood sample was collected in the second month after their final injection to test the anti-HBs levels; while in group C, the blood sample was collected in the second month after the first and the second injection to test the anti-HBs levels. Adverse events were collected after each dose to assess the vaccines' safety.Results: The seroprotection rates were 93.17%, 97.23%, 93.54% and 98.98% respectively and the geometric mean titers (GMTs) were 1033.38 mIU/ml, 600.75 mIU/ml, 265.69 mIU/ml and 1627.05 mIU/ml in group A,B,C and D respectively. The difference of seroprotection rate among the 4 groups was statistically significant (χ2 = 17.26, P<0.05). The difference of titers of anti-HBs among the 4 groups was statistically significant (H = 162.42, P<0.05). BMI, age (older than 40) and smoking were the influence factors of anti-HBs levels on 60 μg hepatitis B vaccine.Conclusion: 60 μg hepatitis B vaccine has a satisfactory safety and seroprotection rate in adult, It could be used in rapid adult hepatitis B immunization.
Hepatitis B vaccine
Hepatitis B
Vaccination schedule
Group B
Cite
Citations (6)
Hepatitis B vaccine is a preventive biological products,hepatitis B vaccine is the most effective measure to prevent hepatitis B.However,the occasional injection of the vaccine in children killed or disabled on the report once again aroused concern about the safety of hepatitis B vaccine,the production and circulation problems in vaccination and other sectors of the hepatitis B vaccine may lead to fatal incidents.Analysis of the causes of death has a positive effect for the development of hepatitis B vaccine industry.
Hepatitis B vaccine
Hepatitis B
Hepatitis A vaccine
Cite
Citations (0)
OBJECTIVE To study the epidemic status of hepatitis B in different groups in Qidong,and evaluate the hepatitis B vaccine immunization effect,provide scientific basis for formulating control measures.METHODS Questionnaire survey was used to investigate different immunization strategies for the coverage of first hepatitis B vaccine immunization in time and the whole course vaccination rate,and detection of 1 ~59 year-old crowd carry rate of HBsAg and anti-HBs level.RESULTS The positive rate of 1~59 years old I different hepatitis B HBsAg 2.39%,hepatitis B anti-HBs positive rate was 35.79%,the hepatitis B vaccine immunization management period(1992—2001),the population coverage rate of hepatitis B vaccine and first hepatitis B timely vaccine immunization rate was95.24%,69.05%,hepatitis B vaccine immunization period(after 2002) the crowd vaccination rate and timely rate of 99.67%,94.12%.CONCLUSION After the implementation of vaccination for newborns from 1992,HBsAg positive rate was decreased obviously,illustrate the hepatitis B vaccine has played a positive role in blocking HBV mother-to-child transmission,which is a significant effect.In 2002,hepatitis B vaccine immunization for children program,the vaccination rate of hepatitis B vaccine and hepatitis B first inoculation rate has been greatly improved,which has reached the planning proposed the target of 2006—2010 national hepatitis B prevention and control.
Hepatitis B vaccine
Hepatitis B
Cite
Citations (0)