Breast Coil Optimization for Low Field MRI and future MR-guided Proton Therapy
Torben P.P. HornungNéha KoonjooSheng ShenFriderike K. LongarinoKathryn E. KeenanSusu YanThomas BortfeldMatthew S. Rosen
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Transcranial magnetic stimulation (TMS) is a new tool for the study of the human brain and for neurological therapeutics. Magnetic coil design is very important in the TMS technique. Precise spatial localization of stimulation sites is the key of efficient functional magnetic stimulations. This paper develops circular coils, figure-of-8 coils and coil array elements in order to realize a transcranial magnetic stimulator, and analyses the coil properties. The results show that different coils have different focus.
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A new miniaturized figure-of-eight coil (μCoil) for TMS applications has been developed taking advantage of the Flex circuit technology. First experiments on volunteers demonstrated the ability of the μCoil to elicit sensorial action potentials of the peripheral nervous system. The necessity of reducing the size of standard TMS stimulator arises from the poor spatial resolution of the latter. This study aims to model the μCoil and study the electromagnetic fields induced inside the arm during peripheral nerve stimulation. Results confirmed that the μCoil is capable of inducing a focalized electric field inside the tissues with amplitudes up to 70V/m consistent with the observed peripheral nerve stimulation in healthy volunteers.
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Biomagnetism is the measurement of the weak magnetic fields produced by nerves and muscle. The magnetic field of the heart—the magnetocardiogram (MCG)—is the largest biomagnetic signal generated by the body and was the first measured. Magnetic fields have been detected from isolated tissue, such as a peripheral nerve or cardiac muscle, and these studies have provided insights into the fundamental properties of biomagnetism. The magnetic field of the brain—the magnetoencephalogram (MEG)—has generated much interest and has potential clinical applications to epilepsy, migraine, and psychiatric disorders. The biomagnetic inverse problem, calculating the electrical sources inside the brain from magnetic field recordings made outside the head, is difficult, but several techniques have been introduced to solve it. Traditionally, biomagnetic fields are recorded using superconducting quantum interference device (SQUID) magnetometers, but recently, new sensors have been developed that allow magnetic measurements without the cryogenic technology required for SQUIDs.
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The goal of this session is to review the physics of proton therapy, treatment planning techniques, and the use of volumetric imaging in proton therapy. The course material covers the physics of proton interaction with matter and physical characteristics of clinical proton beams. It will provide information on proton delivery systems and beam delivery techniques for double scattering (DS), uniform scanning (US), and pencil beam scanning (PBS). The session covers the treatment planning strategies used in DS, US, and PBS for various anatomical sites, methods to address uncertainties in proton therapy and uncertainty mitigation to generate robust treatment plans. It introduces the audience to the current status of image guided proton therapy and clinical applications of CBCT for proton therapy. It outlines the importance of volumetric imaging in proton therapy. Learning Objectives: Gain knowledge in proton therapy physics, and treatment planning for proton therapy including intensity modulated proton therapy. The current state of volumetric image guidance equipment in proton therapy. Clinical applications of CBCT and its advantage over orthogonal imaging for proton therapy. B. Teo, B.K Teo had received travel funds from IBA in 2015.
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Our studies have demonstrated effective stimulation of the bladder, bowel, and expiratory muscles in patients with spinal cord injury using functional magnetic stimulation, However, one limitation of the magnetic coils (MC) is related to their inability to specifically stimulate the target tissue without activation of surrounding tissue. The primary goal of this study was to determine the governing parameters in the MC design, such as coil configuration, diameter, and number of turns in one loop of the coil. By varying these parameters, our approach was to design, construct, and evaluate the induced electric field distributions of two sets of novel MC's. Based on the slinky coil design, the first set of coils was constructed to compare their abilities in generating induced electric fields for focal nerve excitation. The second set of coils was built to determine the effect that changes in two parameters, coil diameter and number of turns in one loop, had on field penetration. The results showed that the slinky coil design produced more focalized stimulation when compared to the planar round coils. The primary-to-secondary peak ratios of the induced electric field from slinky 1 to 5 were 1.00, 2.20, 2.85, 2.62, and 3.53. We also determined that coils with larger diameters had better penetration than those with smaller diameters. Coils with less number of turns in one loop had higher initial field strengths; when compared to coils that had more turns per loop, initial field strengths remained higher as distance from the coil increased. In our attempt to customize MC design according to each functional magnetic stimulation application and patients of different sizes, the parameters of MC explored in this study may facilitate designing an optimal MC for a certain clinical application.
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The article contains sections titled: Biomagnetism History Biomagnetic Fields Gradiometers Shielding: Magnetically and Electrically Shielded Rooms Dewar/Cryostat Commercial Biomagnetic Measurement Devices Special Biomagnetic Measurement Devices and Applications High‐ T c SQUIDs in Biomagnetism Conclusion
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Functional magnetic stimulation (FMS) is a new technique for stimulating the excitable tissue. But the difficulty to locate the activation point and the poor capability of focusing limit the further progress of FMS. A new stimulation method using 8-shaped coil and a combinatorial coil were presented to improve coils performance.The distribution of the induced electrical field was calculated based on Faraday law.When the nerve was perpendicular to the handle of 8-shaped coil and tangential to the coil edge, the position with the maximum of first spatial gradient of the field did not change with the varying of the radius of coil and the excitation depth; the values of the first spatial gradient of field above the stimulation target decreased obviously using the combinatorial coils.Comparing with the current stimulation method of 8-shaped coil, the new method gave a fixed activation point. The capability of focusing was improved using the presented combinatorial coil.
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The goal of this session is to review the physics of proton therapy, treatment planning techniques, and the use of volumetric imaging in proton therapy. The course material covers the physics of proton interaction with matter and physical characteristics of clinical proton beams. It will provide information on proton delivery systems and beam delivery techniques for double scattering (DS), uniform scanning (US), and pencil beam scanning (PBS). The session covers the treatment planning strategies used in DS, US, and PBS for various anatomical sites, methods to address uncertainties in proton therapy and uncertainty mitigation to generate robust treatment plans. It introduces the audience to the current status of image guided proton therapy and clinical applications of CBCT for proton therapy. It outlines the importance of volumetric imaging in proton therapy. Learning Objectives: Gain knowledge in proton therapy physics, and treatment planning for proton therapy including intensity modulated proton therapy. The current state of volumetric image guidance equipment in proton therapy. Clinical applications of CBCT and its advantage over orthogonal imaging for proton therapy. B. Teo, B.K Teo had received travel funds from IBA in 2015.
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The goal of this session is to review the physics of proton therapy, treatment planning techniques, and the use of volumetric imaging in proton therapy. The course material covers the physics of proton interaction with matter and physical characteristics of clinical proton beams. It will provide information on proton delivery systems and beam delivery techniques for double scattering (DS), uniform scanning (US), and pencil beam scanning (PBS). The session covers the treatment planning strategies used in DS, US, and PBS for various anatomical sites, methods to address uncertainties in proton therapy and uncertainty mitigation to generate robust treatment plans. It introduces the audience to the current status of image guided proton therapy and clinical applications of CBCT for proton therapy. It outlines the importance of volumetric imaging in proton therapy. Learning Objectives: Gain knowledge in proton therapy physics, and treatment planning for proton therapy including intensity modulated proton therapy. The current state of volumetric image guidance equipment in proton therapy. Clinical applications of CBCT and its advantage over orthogonal imaging for proton therapy. B. Teo, B.K Teo had received travel funds from IBA in 2015.
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