Regulatory T Cell Derived Trefoil Factor 1 Drives Thymic Regeneration in Allogeneic Hematopoietic Cell Transplantation
Jonah PierceBrianna GipsonLucia Serrano-MarinKimon V. ArgyropoulosSusan DeWolfScott E. JamesManpreet KaurAnastasia I. KousaChi L. NguyenAdhithi RajagopalanKristen VictorKarsten WeisAndri L. LemarquisMarcel R.M. van den Brink
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Keywords:
Trefoil
Transplantation Chimera
Hematopoietic chimerism is a measure of the number of donor and recipient cells in the host following hematopoietic stem cell transplantation (HSCT), and it has a good correlation with GVHD and relapse. Chimerism detection after nonmyeloablative allo-HSCT is a simple essential and effective method to predict the outcome of the disease, and can significantly improve the success rate of transplants, reduce the recurrence and then improve the quanlity of life of patients.
Key words:
Chimerism; Hematopoietic stem cell transplantation; Transplantation immunology
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