Simultaneous two-voxel functional magnetic resonance spectroscopy of the motor cortex at 7T
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Motivation: Functional magnetic resonance spectroscopy (fMRS) shows promise in studying task-related metabolite changes but has been largely confined to single-voxel. Goal(s): To evaluate two-voxel fMRS at 7 T to measure simultaneous bilateral metabolite changes during a unilateral motor task. Approach: A modified Hadamard-encoded MRS scheme with dynamic fMRS spectral-temporal fitting for analysis was employed. Results: Distinct patterns of BOLD activation in contra- and ipsilateral VOIs were detected with significant increases in Glutamate (Glu) in either VOI during a unilateral taskImpact: We demonstrate the feasibility of simultaneous two-voxel MRS to detect bilateral glutamate changes in response to a unilateral motor task. This approach holds promise to increase our understanding of the neurochemical underpinnings of fMRI signals across interconnected brain regions.Keywords:
Biomagnetism
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Functional Imaging
Brain mapping
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Functional Imaging
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This conference reviewed the potential scope of application for recently developed techniques for functional magnetic resonance imaging (fMRI) of the brain.The most successful technique is based on the sensitivity of magnetic resonance imaging (MRI) to magnetic effects caused by the modulation of the oxygenation state of hemoglobin, which is induced by local variations in blood flow during task activation. Typically, the MRI signal increases by a few percentage points during brain activation because blood flow and oxygen supply sharply increase. Brain activation images with excellent combined spatial and temporal resolution have been obtained noninvasively using visual, sensorimotor, or auditory stimuli, or during higher-order cognitive processes such as language or mental imagery. Although sensitive to misregistration artifacts and macroscopic vessels, MRI permits both the direct correlation of function with underlying anatomy and repeated studies on the same person. It may become the method of choice for studies of mental and cognitive processes, presurgical mapping, monitoring recovery from stroke or head injuries, exploration of seizure disorders, or monitoring the effects of neuropharmaceuticals.
Blood-oxygen-level dependent
Blood oxygenation
Functional Imaging
Temporal resolution
Brain mapping
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Functional Imaging
Human brain
Brain Function
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Blood oxygenation
SIGNAL (programming language)
Human brain
Brain Function
Brain mapping
EEG-fMRI
Functional Imaging
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Discriminative model
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Objective To explore functional magnetic resonance imaging(fMRI)of motor cortex by using echo planar imaging(EPI) and blood oxygenation level dependent(BOLD)contrast.Methods Twenty-seven healthy volunteers were included in this experiment.Motor stimulation was induced by repetitive pressing the rubber roll of right hand of the volunteers.The echo planar images of the motor cortex were acquired at motion stimulation and rest phases.T-test analysis was used to statistically generate the activation map.Results The activation areas were found in contralateral sensorimotor area,bilateral supplementary motor area and so on.Conclusion fMRI could be used to study human functional cortex.A preliminary location of the motor cortex can be acquired through motor stimulation.
Blood oxygenation
Supplementary motor area
Sensorimotor cortex
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