Supplementary Figure S5 from A Dual-Payload Antibody–Drug Conjugate Targeting CD276/B7-H3 Elicits Cytotoxicity and Immune Activation in Triple-Negative Breast Cancer
0
Citation
0
Reference
10
Related Paper
Abstract:
<p>Supplementary Figure S5</p>Keywords:
Triple-negative breast cancer
Conjugate
Antibody-drug conjugate
Payload (computing)
Payload (computing)
Cite
Citations (440)
Abstract Benzalcyanoacetamides were designed and synthesized as reversible thiol conjugate addition acceptors. These thia‐conjugate additions can rapidly and reversibly achieve equilibrium under aqueous conditions at neutral pH. Kinetic studies show that electron‐withdrawing groups at the 4‐position of the phenyl ring of the benzalcyanoacetamides promote the conjugate addition at equilibrium. Dynamic thiol exchange of these conjugate acceptors is faster than singly activated α,β‐unsaturated carbonyl compounds. These thia‐conjugate additions can be assembled as potentially useful components in dynamic combinatorial chemistry.
Conjugate
Thiol
Aqueous medium
Cite
Citations (50)
Antibody-drug conjugates offer the possibility of directing powerful cytotoxic agents to a malignant tumor while sparing normal tissue. The challenge is to select an antibody target expressed exclusively or at highly elevated levels on the surface of tumor cells and either not all or at low levels on normal cells. The current review explores 78 targets that have been explored as antibody-drug conjugate targets. Some of these targets have been abandoned, 9 or more are the targets of FDA-approved drugs, and most remain active clinical interest. Antibody-drug conjugates require potent cytotoxic drug payloads, several of these small molecules are discussed, as are the linkers between the protein component and small molecule components of the conjugates. Finally, conclusions regarding the elements for the successful antibody-drug conjugate are discussed.
Conjugate
Antibody-drug conjugate
Cite
Citations (22)
Amyloid (mycology)
Cite
Citations (7)
Conjugate
Antibody-drug conjugate
Subclass
Linker
Cite
Citations (16)
Objective:Assess cytotoxicity of medical device with silver nanoparticles and assay the reason of the cytotoxicity.Method:The nine kinds of silver nanoparticle samples in three types were tested by MTT cytotoxicity method.Result:The test showed that the cytotoxic ity in 9 final samples all were grade 3 to 4;the gels and dressings which are semi-finished products without silver nanoparticles,were grade 1 of cytotoxicity;patches were grade 4 of cytotoxicity;patches without adhesive were grade 1 of cytotoxicity.Conclusion:Silver nanoparticle medical devices in the present test showed moderate or severe cytotoxicity.Gels or dressings only which without silver nanoparticle showed slightly cytotoxicity.Patches only which without silver nanoparticle showed severe cytotoxicity,and adhesive is the main reason of the cytotoxicity.Whether the severe cytotoxicity will induce persist cell damage,and the detail mechanisms of silver nanoparticle or adhesive-induced cytotoxicity need further investigation.
Silver nanoparticle
Cite
Citations (1)
The purpose of this study is to examine the protective effect of Cynomorii herba on -induced cytotoxicity in male germ cells. The effects were studied by a modified MTT assay. Hydrogen peroxide significantly induced cytotoxicity in GC-1 spg cells, and co-treatment or pre-treatment of Cynomorii herba extract has reduced the cytotoxicity in a dose dependant manner. These results suggest that Cynomorii herba extract increases the survival rate of GC-1 spg cells through the antioxidant effect against -induced cytotoxicity.
MTT assay
Cite
Citations (0)
Eight aza-chalcones L1-8 and eight new platinum(IV) complexes C1-8 with aza-chalcones were synthesized. The complexes have been characterized by elemental anaylsis, IR spectra, electronic spectrum and 1H NMR. The cytotoxicity was tested byMTT assays and compared with the cytotoxicity of cisplatinum. The results indicate that the complexes C1-3 and C5-8 have cytotoxicity against tested A-549 cell line; moreover, the cytotoxicity of complexes C6 approached cisplatinum. The complexes C3, C4 and C6 have cytotoxicity against tested Hela cell line, but the cytotoxicity of these complexes is lower than cisplatinum.Most of the coorespounding ligands have no cytotoxicity against tested two cell lines, and the cytotoxicity of all ligands is lower than complexes.The results suggest that the cytotoxicity of all complexes againstA-549 cell line is better than against Hela cell line.
HeLa
Cite
Citations (0)
For more than ten years hundreds of payloads have been, and are currently being, successfully operated onboard the ISS. These payloads are operated by a diverse set of users all over the world. Due to the current international economic environment payload operations are being streamlined, in more and more cases, by using the payload investigators and scientists to also fill the role of operators. Taking this into consideration, increasingly, we have payload operators that are new to space operations and practices, therefore ground systems training and support have become a more critical aspect in ensuring a successful payload mission. The ISS ground systems payload interface is the Payload Operations and Integration Center (POIC), located at Marshall Space Flight Center. ISS ground systems training for all remote ISS payload operators, as well as the ISS POIC CADRE, are centralized at this facility. The POIC is the starting point for a remote payload operator to learn how to integrate, and operate their payload, successfully onboard the ISS. Additionally, the CADRE that supports the payload user community are trained and operate from this facility. This paper will give an overview of the ISS ground systems at the POIC, as it relates to the payload user/operator and CADRE community. The entire training process from initial contact with the POIC to in-flight operations will be reviewed and improvements to this process will be presented. More importantly we will present current training methods and proposed methodology whereby the user community will be trained more efficiently and thoroughly. Also, we will discuss how we can more effectively support users in their operations concept to programmatically conduct certain aspects of payload operations to reduce costs.
Payload (computing)
International Space Station
Interface (matter)
Cite
Citations (0)
For legged devices, their ability of carrying payload is a necessity for a wide range of tasks. In this paper, we present a new approach of carrying payload by using a parallel elastic mechanism, which is able to carry payloads of at least 3 times of its bodyweight. Although the robot has no sensory feedback and consists of only two rigid bodies and one spring loaded joint, it is able to achieve efficient and stable forward hopping for a wide range of attached payload. The presented payload carrier ETH Cargo is based on the further development of our platform CHIARO for the payload range between 0 and 100kg. After parameter optimization using simulations, a series of real world experiments prove stable and high efficiency hopping of the prototype over a wide range of payloads.
Payload (computing)
Cite
Citations (11)