logo
    [Objective] The study was to explore whether antimicrobial activity of the antimicrobial peptides extracted from immunized Tenebrio molitor varied with different pathogens as inducers.[Method]By inducing T.molitor hungry larvaes to generate immune response via feeding with bacteria and with fungi or actinomycete post to pricking,the antimicrobial peptides extracts were obtained by grinding and centrifuging the cultures.Its antimicrobial activity against 26 pathogens was measured by bacteriostatic ring,and evaluated by trisection to four types and inhibitory spectrum.[Result]Both the antimicrobial activity and antimicrobial spectrum of the antimicrobial peptides extracts varied remarkably among different pathogens as inducers.[Conclusion]Bio-control used strains have obvious advantage in inducing the insect to express body fluid immunity material-antimicrobial peptides.
    Citations (1)
    To obtain strong activity antimicrobial agent,the antimicrobial properties of Gemini antimicrobial agents(C1,C2,C3 and C4) were evaluated by quantifying the minimal inhibitory concentration(MIC),n-dodecyl-trimethylammonium bromide(DTAB) as a comparison.The results indicated that these Gemini antimicrobial agents against S.aurueus,E.coli and C.albicans were superior to DTAB.The MIC of C2 against S.aurueus and E.coli were 1.5 μg·L-1 and 3.91 μg·L-1,respectively.The MIC of C4 against C.albicans was 3.91 μg·L-1.these Gemini antimicrobial agents exhibited improved activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as yeast.Their antimicrobial properties rely on the Gemini molecular structures with longer length of main-chain,full-chain and R groups,their antimicrobial activities are stronger,and fluorinated alkyl groups can markedly improve their antimicrobial properties compared with the same hydrocarbon one.
    Citations (0)
    Mushrooms have an acclaimed history of therapeutic use in traditional medicine. The prevalent occurrence of infectious diseases is becoming a worldwide problem, due to bacterial resistance against antimicrobial drugs which have been long used for therapeutic and prophylactic purposes. For this reason, the search has intensified for natural sources with antimicrobial activity. The literature contains scientific data about the high antimicrobial activity of mushrooms against Gram-positive and Gram-negative bacterial species. In this review we have focused on compounds obtained from mushrooms which exhibit antimicrobial activity, commonly used methods for evaluation of antimicrobial activity and last but not least on syntheses of some selected compounds originally isolated from mushrooms. Keywords: Mushrooms, extracts, antimicrobial activity, synthesis, MIC.
    The objective of this study is to determine using as biological control agent against Tribolium confusum du Val., 1863 (Coleoptera: Tenebrionidae) adults of seven entomopathogenic fungal treatments, Beauveria bassiana, Paecilomyces farinosus, Isaria fumosorosea, Isaria farinosa, Lecanicillium muscarium (2 isolates) and an extract of L. muscarium, under laboratory conditions (25±1°C and 75±1% RH).Fungal isolates at two different concentrations (1x10 5 and 1×10 7 conidia/mL) were sprayed on the tested adult insects in Petri dishes.The results demonstrated that the mortality rates of T. confusum adults treated with seven entomopathogenic fungi varied from 34.6 to 100% after 10 days of treatment.The entomopathogenic fungi isolates at both 1×10 5 and 1×10 7 conidia concentration caused in high mortality levels of T. confusum adults.In conclusion, it was observed that tested seven entomopathogenic fungi isolates might have a potential effect to biological control of this stored-product pest.
    Citations (14)
    [Objective] The study was to explore whether antimicrobial activity of the antimicrobial peptides extracted from immunized Tenebrio molitor vary with different pathogens as inducers.[Method] By inducing hungry T.molitor larvaes to generate immune response via feeding with bacteria and with fungi or actinomycete after pricking,the antimicrobial peptide extract was obtained by grinding and centrifuging the cultures.Its antimicrobial activity against 26 pathogens was measured by bacteriostatic ring,and evaluated by trisection to four types and inhibitory spectrum.[Result] Both the antimicrobial activity and antimicrobial spectrum of the antimicrobial peptide extract varied remarkably among different pathogens as inducers.[Conclusion] Bio-control used strains have obvious advantage in inducing the insect to express body fluid immunity material-antimicrobial peptides.
    Citations (0)
    Objective To evaluate the antimicrobial agents usage in a hospital. Methods Forty patients’ medical records were selected for retrospective analysis, patients were discharged in the year of 1998 and 2000 respectively. Results In 1998, antimicrobial resistant rate was higher, 96.25% of patients received antimicrobial agents, antimicrobial cost accounted for 52.38% of the total hospitalization expense; most antimicrobial agents were for treatment, the majority of patients received two kinds of antimicrobial agents simultaneously; in 2002, 93.54% of patients received antimicrobial agents, antimicrobial cost accounted for 50.47% , most antimicrobial agents were for treatment, and majority of patients only received one kind of antimicrobial drugs. There was significant difference in the total usage rate of antimicrobial agents between two surveys. Conclusion Target surveillance on antimicrobial agents usage should be carried out to reduce the overuse of antimicrobial agents and decrease the bacterial resistance.
    Citations (0)
    A new series of substituted 2-mercapto-3-(4-chlorophenyl)-6-iodo-3H-quinazolin-4-ones was prepared and screened for antimicrobial activity. Compounds 11, 13, 17, and 18 showed a remarkably broad spectrum of antimicrobial activity and could be useful as templates for further development through modification or derivatization to design more potent antimicrobial agents. A detailed synthesis of new 2-mercaptoquinazolinones and their antimicrobial screening are reported.
    Broad spectrum
    Citations (39)
    Objective: To investigate the problems in the usage of antimicrobial agents in a hospital and provide guidan-ce for the rational use of antimicrobial agents in clinic. Methods: Antimicrobial usage in patients who were discharged from hospital in January,2006 was analysed retrospectively by medical record reviewing. Results: 1 379 of 1 780 discharged patients (77.47%) used antimicrobial agents ,47.50% were for preventive administration;234(16.97%) patients used only1 kind of antimicrobial agent.The commonly used antimicrobial agents were the third generation cephalosporins, quinolones, penicillins, 52.57% of patients used antimicrobial agents for less than 7 days and 27.41% for more than 14 days.Samples from only 7.11% of patients used antimicrobial agents were performed antimicrobial susceptibility test. Conclusions: Some patients used antimicrobial agents irrationally ,detection rates of samples for antimicrobial susceptibillty test was low ,the usage of antimicrobial agents should be paid attention.[
    Citations (0)
    In this review, it was searched conducted research studies on antimicrobial properties of marine macroalgae extracts. Many researchers were studied to determine the antimicrobial activity of macroalgae extracts. In several literatures stated that have been found antimicrobial activity in the extracts of green, brown and red macroalgae against fungi, yeast and bacteria. The antimicrobial compounds derived from consist of diverse groups of chemical compounds (aminoacids, fatty acid, terponoids, phlorotannins, phenolic compounds, steroids, halogenated ketones and alkanes etc.). The aim of this review was to investigate antimicrobial properties of marine macroalgae extracts and to indicate antimicrobial activities against microorganism .