Fabrication of polydopamine functionalized AgNF SERS substrate: Applications for sensitive detection of nivalenol in food samples and cell biocompatibility
Sintayehu Leshe KitawYohannis Wondosen AhmedDarieo ThankachanAndy CandraTsung-Yun WuBeyadgalem Endawoke AnleyYu-Xuan GouYingyu ChenYu-Ting ChengYihenew Simegniew BirhanKuan‐Ju ChenHsieh‐Chih Tsai
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Biocompatibility
Biocompatibility is a very common word that is used within biomaterial science and used for description of the interactions between the foreign material and the body. However, the meaning of biocompatibility as well as the mechanisms that collectively constitutes is still unclear. With the advance of nanotechnology, new concerns have been observed related to biocompatibility of these biomaterials. Due to their small size and variability of their physical and chemical properties, nanoparticles' (NP) distribution within the body and interactions with the target cells and tissues are highly variable. Here, we tried to provide an overview about NPs, the concept of biocompatibility and biocompatibility-related issues in nanomedicine and several different NPs.
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Fibrosis caused by the host response to long-term transplanted microcapsules and the limitation of traditional L929 cell model for biocompatibility testing inspire the development of an assay of biocompatibility based on macrophage behavior. In this paper, the human monocytic cell line THP-1 was utilized for biocompatibility evaluation of microcapsule materials. The cell viability and secretion of nitric oxide (NO) and cytokines served as index of biocompatibility were assayed. It was found that the evaluated microcapsule materials had no effect on the stimulation of NO and cytokines secretion, which meant that these materials were biocompatible. Furthermore, it suggests the THP-1 cell a convenient in vitro experimental model that might be useful for long-term predictions of material biocompatibility.
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Objective To study the preparation and biocompatibility of modified poly(propylene carbonate)(M-PPC) so as to provide experimental reference for its clinical applicationMethods M-PPC was generated by blending of PPC and PHB.The biocompatibility evaluation experiments included cell toxicity test by MTT and implantational test of M-PPC.Results All the test results showed that M-PPC induced no cytotoxicity to Hela cell,and M-PPC had good biocompatibility in vivo and in vitro.Conclusion M-PPC is one new kind of safe medical materials which has good biocompatibility.
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Propylene carbonate
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Silk fibroin is a natural biomaterial protein due to its excellent biocompatibility, biodegradability, mechanical property and processibility. The properties of biomaterial scaffolds are quite strict and complex for its practical applica tion in tissue engineering. Recently, many researches on structure biocompatibility and cell biocompatibility of silk fibro in have been conducted. The results showed good biocompatibility of fibroin, which is important for promoting the appli cation of fibroin in tissue engineering.
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Polyurethane(PU) has been widely used biomedical material with good stability,excellent mechanical properties and reasonable biocompatibility due to its specific micro-phase separation structure.However,its unsatisfactory blood compatibility results in limitation of application in the biomaterial fields.As far as the dependence of biocompatibility on surface properties of materials is concerned,surface modification has been recognized a preferable way to improve the biocompatibility for biomaterials.In view of many methods applied to modify the surface of polyurethane,the bioactive molecules modified surface through chemical modification has attracted a great of interest.In the present article the approaches of modification to improve the biocompatibility of polyurethane were briefly summarized,and the relationship between polyurethane surface properties and biocompatibility was also discussed.
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Background: Biocompatibility and the efficiency of solute removal are important considerations in blood purification therapy. Improvement of biocompatibility is expected to lead to the prevention of dialysis-related complications (e.g. amyloidosis, arteriosclerosis, and malnutrition) and to the delay of disease progression by alleviating microinflammation. Summary: The biocompatibility of dialyzers is greatly influenced by the interaction between blood and the treatment materials, in which the chemical and physical characteristics of membrane materials play important roles. In hemodiafiltration (HDF), treatment characteristics such as dilution modes are also considered to greatly affect this interaction between blood and materials. Studies have reported that the levels of C-reactive protein are decreased in patients receiving HDF. Thus, the improvement of biocompatibility is an important factor in HDF. Key Messages: To improve the biocompatibility of HDF, it is essential to improve the biocompatibility of hemodiafilters. This article outlines the importance of biocompatibility and related factors in HDF.
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