COMPARATIVE ANALYSIS OF SPONDYLOARTHRITIS MANIFESTATIONS, DISEASE ACTIVITY SCORE AND TREATMENT IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
Carolina Zorzanelli CostaValquíria Garcia DinisWeider Andrade ToméLivia Camara OliveiraRaquel Altoé GiovelliRenata Vilela de Almeida GomesLuana Assis MarquezBárbara Araújo Cristelo de MoraesGustavo Jose Rossoni RonchiFelipe Bertollo FerreiraFelipe Welling LorentzMariana Poltronieri PachecoAna ClaraFabiano Machado MartinsLívia Zardo Trindade
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Outcome measurement in spondylarthritis, particularly
ankylosing spondylitis (AS) has been a rapidly growing
field over the last decade, with enormous progress being
made in patient-reported outcomes, clinical assessments,
physical measurements and composite scoring of disease
state, and response to treatment. Many of these advances
arose out of need, when anti–tumor necrosis factor therapies
were found to have a role in the treatment of AS
patients and therefore required appropriate clinical assessment.
The Assessment of SpondyloArthritis international
Society (ASAS) was first formed in 1995 as a group of
clinicians and methodologists with a shared interest in
outcome measurement in AS patients, and has grown to
incorporate early diagnosis, classification, development
and validation of outcome measures, and evaluation of
therapeutic modalities.
The instruments reviewed here include those recommended
in the ASAS core sets for clinical record keeping
(in daily clinical practice) and for clinical research, as over
time these have been extensively validated and implemented
across different clinical settings. The core sets
describe those health-related domains that should be
measured in AS patients in different settings, and recommend
appropriate instruments that can be used for that
domain. Additional measures included are the AS Quality
of Life scale and the Health Assessment Questionnaire for
the Spondylarthropathies, which cover health domains
not included in the original core sets but have been shown
to be important to AS patients through the World Health
Organization International Classification of Functioning,
Disability and Health projects (1). Finally, the AS Disease
Activity Score has also been presented, as an alternative to
the Bath Ankylosing Spondylitis Disease Activity Index,
as one of the newest measures constructed to assess disease
activity.
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