Irradiated engineered tumor cell-derived microparticles remodel the tumor immune microenvironment and enhance antitumor immunity
Yan HuYajie SunZhiyun LiaoDandan AnXixi LiuYang XiaoYu TianSuke DengJingshu MengYi‐Jun WangJie LiYue DengZhiyuan ZhouQin-Yan ChenYing YeWenwen WeiBian WuJonathan F. LovellHonglin JinFang HuangChao WanKunyu Yang
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Cell mediated immunity
Tumor microenvironment is a spatial structure including many kinds of cells and stroma around them,which interact each other to form a variety of crosstalks.Current research confirms that tumor progress and metastasis are involved in autocrine and paracrine by peritumor cells,which create a robust system that can regulate their response to treatment.Non-tumor cells in tumor environment play a crucial role.Proposed here is the therapy for cancer treatment,which could be more effective in destruction of the tumor microenvironment than just killing the tumor cells.
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The continuous effect of radiocobalt (Co/sup 60/) on cell immunity was studied. The data show that chronic irradiation in low doses disturbs cell immunity. Confrontation of disturbances of the humoral and cell immunity divulged that they occur simultaneously in the irradiated organism. The phase of inhibition is preceded by the phase of stimulation. (auth)
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Cell mediated immunity
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Cell mediated immunity
Marek's disease
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This paper presents a review of 123 cases of leprosy of different clinical types as regards to their status of cellular immunity. These 123 cases included 41 fresh cases, 18 cases of reaction and 64 cases of leprosy taking antileprosy treatment. Out of 41 untreated cases only 11 turned up for follow up and their lymphoblastic transformation was repeated 4 to 6 months after initiating the treatment. It was observed that cell mediated immunity as expressed in terms of percentage of blast cells is definitely depressed in leprosy, most in LL and least in TT. There is a definite increase in the percentage of blast cells after taking antileprosy treatment. The rise in percentage of blast cells and hence cellular immunity is relatively more in patients treated with Lamprene as compared to those treated with DDS. Reactions also have impact over immunity in leprosy. Thus, most of the patients with ENL show higher values for blast percentage as compared to those with lepra reaction. It appears that serial lymphocyte cultures if done in all cases of leprosy undergoing treatment will help in assessment of individual progress.
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ABSTRACT: The role of cell‐mediated immunity (CMI) in wart infection was demonstrated. The correlation with humoral immunity was also suggested. Patients with cell‐mediated immune deficiency were found to be more susceptible to wart infection than those with humoral immune deficiency.
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Experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of Nocardia asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.
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Objective:To observe the effect of compound decotion Caiyu on the immunity system of immunity hepatic damage mice.Methods:72 mice were randomly divided intonormal group,model group,control group and three therapy groups.The model of immunity heaptic damage were made by injecting BCG+LPS.ALT active unit in serum,activity of NK cell,percentage of CD+3、CD+4、CD+8 and CD+4/CD+8 of every group were determinated.Results:Percentage of CD+3、CD+4 cell and CD+4/CD+8 and activity of NK cell of three therapy groups was obviously higher than that of model group.Conclusion:Ddecoction Caiyu can strengthen the T-cell immunity function of the mice and adjust the net of the T-cell immunity,also strengthen the NK cell activity.
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Cellular immunity to Chlamydia trachomatis is not well understood. Studies with the mouse pneumonitis agent in a mouse pneumonia model suggest a strong thymic component to immunity and a role for the macrophage as an effector cell in cell-mediated immunity to C. trachomatis. Experiments with Chlamydia psittaci indicate that cellular cytotoxic mechanisms and biostatic or cytotoxic mechanisms involving cytokines may also play a role in host defense against chlamydiae. Interferon has been shown to inhibit intracellular growth of both C. trachomatis and C. psittaci in vitro. Further studies are needed on the role of T lymphocytes or lymphokines and macrophages in limiting the growth of C. trachomatis in conjunctival epithelial cells (the most appropriate target cells) and in exerting a toxic effect on these cells. The evidence suggests that macrophages are activated during C. trachomatis infection; this activation may lead to the release of monokines (such as interleukin 1) that may be important in the pathogenesis of scarring due to over-stimulation of cellular immunity during ocular infection. Cell-mediated immunity to ocular infection with C. trachomatis may thus be a double-edged sword.
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Experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of Nocardia asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.
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Delayed hypersensitivity
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