Supplementary Table 2 from Early Immune Changes Support Signet Ring Cell Dormancy in <i>CDH1</i>-Driven Hereditary Diffuse Gastric Carcinogenesis
Benjamin L. GreenLauren A. GambleLaurence P. DiggsDarryl NousomeJesse C. PattersonBrian A. JoughinBillel GasmiStephanie C. LuxSarah G. SamaranayakeMarkku MiettinenMartha QuezadoJonathan M. HernandezMichael B. YaffeJeremy L. Davis
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<p>Generation of second messenger molecules.</p>Keywords:
CDH1
Signet ring cell
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Primary signet-ring cell carcinoma (SRCC) is an extremely rare and aggressive type of malignant gallbladder (GB) neoplasm, which is comprised predominantly (>50%) of signet-ring cells. Owing to its diffusely invading nature, SRCC often confers a linitis plastica like appearance to GB. Such a gross morphology in the background of nonspecific clinical presentation creates confusion with several other benign and more common pathological entities. This dilemma can effectively be settled through clinical, radiological, and pathological correlation. We, here, describe a case of SRCC affecting the GB in a 43-year-old lady. The tumor produced diffuse thickening of GB wall and infiltrated up to subserosa, but not beyond the GB parenchyma.
Linitis plastica
Signet ring cell
Chronic cholecystitis
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Scattered single cells or variable sized clusters of signet ring cells in the aspirated smears of breast lesions are almost exclusively associated with carcinoma. The signet ring cells are defined as those containing a prominent intracytoplasmic vacuole or amorphous cytoplasm diffusely dispersed with mucin. The primary signet ring cell carcinoma of the breast behaves more aggressively than carcinoma without signet ring cells. Therefore, it is very important to make a correct diagnosis of signet ring cell carcinoma. Fine needle aspiration cytology is useful for diagnosis of breast lesions Including signet ring cell carcinoma. We report two cases, which showed mostly signet ring cells in the aspirated smears of the breast. One case consisted of numerous individual signet ring cells and variable sized cell clusters in rather mucoid background. The tumor cells had abundant amorphous cytoplasm filled with dispersed mucin or occasionally mucin vacuoles(PAS +) and eccentric nuclei. The resected mass revealed mucinous carcinoma. The other showed the cytologic findings of low cellularity, and small loosely cohesive signet ring cell clusters with mild nuclear pleomorphism. It was confirmed as lobular signet ring cell carcinoma in the resected tumor.
Signet ring cell
Pleomorphism (cytology)
Breast carcinoma
Lobular carcinoma
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Signet ring cell
Univariate analysis
Stomach cancer
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Signet ring cell
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Signet ring cell
Primary tumor
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Primary signet-ring cell carcinoma (PSRCC) is a rare pathological subtype of colorectal cancer, characterized by the presence of malignant signet ring cells. We report the case of PSRCC in an elderly female who was misdiagnosed on preoperative biopsy. PSRCC is usually diagnosed in young adults; the most common site is the ascending colon. It is clinically aggressive and has a poor prognosis. The distinctive signet ring cells, however, can often be misinterpreted as other benign cells: the so-called “benign signet-ring change.” Accurate and timely diagnosis of signet ring cell carcinoma is important because of its aggressive clinical course. Distinction from benign entities requires clinical and radiological correlation as well as a proper morphological assessment in conjunction with immunohistochemistry evaluation.
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Ascending colon
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To compare the clinicopathological features of signet ring cell gastric carcinoma (SRCC) with those of non-signet ring cell cancers and explore the prognostic factors of signet ring cell gastric carcinoma.We retrospectively reviewed the medical records of 1447 gastric cancer patients, including gastric signet ring cell and non-signet ring cell cancers. Their clinicopathological characteristics and overall survival data were analyzed.The differences in the age, sex, tumor location, depth of invasion, lymph node metastasis, distant metastasis, TNM classification and surgical type were significant between gastric signet ring cell and non-signet ring cell gastric carcinomas. The 5-year survival rate of the patients with gastric signet ring cell carcinoma was 29.6%, while that of the non-signet ring cell cancers was 42.9% (P < 0.05). The 5-year survival rate for each stage of gastric signet ring cell carcinoma and non-signet ring cell cancers was 71.0% and 79.3% for stage I, 45.6% and 58.3% for stage II, 16.9% and 29.2% for stage III, and 6.0% and 11.9% for stage IV cases, respectively, with a significant difference only between stages III and IV cancers (P < 0.05). Multivariate analysis showed that tumor diameter, T stage and N stage were independent prognostic factors for signet ring cell gastric carcinoma.The signet ring cell gastric carcinoma has unique clinicopathological features compared with non-signet ring cell carcinoma. Early detection and treatment can improve the prognosis for patients with gastric signet ring cell carcinoma.
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A 72-year-old woman with signet-ring cell carcinoma of the urinary bladder treated with total cystectomy is described. The bladder yielded linitis plastica pattern of infiltration similar to that seen in the gastric cancer, i.e., cancer tissue extended almost whole bladder deeply to the serosa, whilst the mucosal surface was only minimally invaded. She received no adjuvant therapy and she is alive without recurrence 8 months after the operation. We review the reported cases and shortly discuss the prognosis and treatment of primary signet-ring cell carcinoma of the urinary bladder.
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Linitis plastica
Infiltration (HVAC)
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Objective To study the pathological characters and prognosis of 33 cases of gastric signet ring cell carcinoma.Methods The difference of clinicopathology and survival between signet ring cell carcinoma and non-signet ring cell carcinoma in 166 gastric cancer patients were analyzed restropectively.Results Thirty-three gastric signet ring cell carcinoma was observed in 166 gastric cancer samples(19.88%) and had no relationship with general pathological characters such as sex,lesion location,differentiation,depth of infiltration,lymph node metastasis,distant metastasis and clinical stage(P0.05).Gastric signet ring cell carcinoma patients were younger(age60,P=0.032) and had higher ratio of neural invasion(P=0.021) than those of non-signet ring cell carcinoma patients.The gastric signet ring cell carcinoma patients had poorer 4 years survival rate(42.4%) than that of non-signet ring cell carcinoma patients(66.2%),showing significant differences(P0.05).Conclusion The gastric signet ring cell carcinoma has a worse prognosis compared to non-signet ring cell carcinoma.
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Appendiceal primary signet ring cell carcinoma is an extremely rare neoplasm considered to be more aggressive than other appendiceal tumour. Primary appendiceal carcinoma is diagnosed in only 0.9%–1.4% of appendectomy specimens and signet-ring cell carcinoma (SRCC) of vermiform appendix is accounting 0.43% of all appendiceal malignancies. Patients of SRCC usually present clinically as acute appendicitis. Preoperative imaging detection of appendiceal adenocarcinoma have limited benefit due it has minimal change like appendicitis or wall thickening without any obvious growth. We reported an extremely rare case of primary signet ring cell carcinoma of the vermiform appendix in a 55 year old man. Patient had abdominal pain, anorexia and nausea. He underwent appendectomy for appendicitis and histopathologically diagnosed as appendiceal signet ring cell carcinoma with lymph node metastasis.
Vermiform
Signet ring cell
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