1162. Influenza Vaccination Among Pregnant People in the Vaccine Safety Datalink, 2016-17 through 2022-23 Influenza Seasons
Stephanie A. IrvingBradley CraneEric WeintraubTia L. KauffmanNeon BrooksSuchita A. PatelHilda RazzaghiEdward A. BelongiaMatthew F. DaleyDarios GetahunSungching GlennSimon J. HambidgeLisa A. JacksonElyse O. KharbandaNicola P. KleinOusseny ZerboAllison L. Naleway
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Abstract Background Estimates of influenza vaccination coverage during pregnancy vary, but studies in the US prior to the 2020-21 influenza season show increasing coverage over time. However, there are limited data on influenza vaccination coverage among pregnant people during the COVID-19 pandemic. Methods Within the Vaccine Safety Datalink, we examined influenza vaccination coverage among people ages 18-49 years identified as pregnant with a live birth using a validated algorithm. For primary analyses covering the 2016-17 through 2021-22 influenza seasons, we captured all influenza vaccination between July 1 and March 31 of each season, irrespective of the timing of administration relative to pregnancy (i.e., prior to, during, or after pregnancy), and assessed crude coverage; demographic and clinical characteristics associated with vaccination; and vaccination patterns by calendar month of pregnancy start. Secondary analyses included crude coverage estimates for the 2022-23 season, using data through January 2023, stratified by race and ethnicity. Results In primary analyses, among cohorts of pregnant people ranging from 128,267 to 139,927 each season, crude annual influenza vaccination coverage ranged from a high of 71% (2019-20) to a low of 56% (2021-22). In each of the six seasons, coverage was lowest among 18-24-year-olds (Figure) and among non-Hispanic Black pregnant people. The 2021-22 season had the lowest coverage estimates across all age and race and ethnicity groups. Coverage differed based on the calendar month of pregnancy onset, with the lowest coverage observed among pregnancies starting in January-March during each influenza season. In secondary analyses, overall coverage as of January 2023 was 47.9%, a decrease of 7.7 percentage points from January 2022 estimates. Conclusion Influenza vaccination coverage among all pregnant people increased from the 2016-17 influenza season through the 2019-20 influenza season, then decreased to the lowest level in the 2021-22 season. Interim estimates for the 2022-23 season declined further. The decreases seen in recent seasons, likely due in part to the COVID-19 pandemic, were consistent across all characteristics examined, and highlight the need for continued efforts to improve influenza vaccination coverage in pregnant people. Disclosures Edward Belongia, MD, Seqirus: Grant/Research Support Lisa Jackson, MD, MPH, Pfizer: Grant/Research Support Nicola P. Klein, MD, PhD, GlaxoSmithKline: Grant/Research Support|Merck: Grant/Research Support|Pfizer: Grant/Research Support|Sanofi Pasteur: Grant/Research SupportKeywords:
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To determing the efficacy of a single influenza vaccine administration in the elderly receiving annual influenza vaccination, antibody response to influenza vaccine was compared between once and twice injections in a geriatric cohort. Influenza vaccination had been done for 69 inpatients in the year prior to the study, and was administered twice for 34 of them and once for the other 35 during the study period. Influenza vaccine was injected twice to 77 inpatients who had not received influenza vaccine in the year prior to the study.Hemoagglutination inhibition (HI) antibody titer for influenza A/H1N1, A/H3N2, and B was measured before vaccination, after the first vaccination, after the second vaccination, and after the epidemic period, September 1995 to April 1996. HI antibody titer prior to vaccination was significantly higher in the patients who had received influenza vaccination the previous year. The influenza vaccine induced an increase in HI titer in almost all subjects, and the geometric mean of the HI titer after vaccination in the patients who received vaccine once was comparable to that of the patients injected vaccine twice. The number of patients with HI titers of over 128×increased, and the frequency ranged from 60.0% to 97.1% for the influenza viruses of the three subtypes. The frequency of HI titers over 128×was not significantly different among the three groups. The second vaccination did not increase the number of patients with HI titers over 128×when compared with the number after the first injection in the patients who had received influenza vaccine the previous year. These results suggest that prior vaccination does not diminish the antibody response to influenza vaccine in the elderly. The efficacy of a single influenza vaccination is comparable to that achieved by twice injections in the elderly receiving annual influenza vaccination.
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Purpose: Influenza vaccination program on health care workers was established during 2014–2015. Influenza seasons and influenza vaccine has been recommended for several risk groups. Our purpose is to present an overview of the current influenza vaccination program and evaluate vaccination administration and coverage among health care workers and other risk groups and influencing factors. Methods & Materials: Questionnaire were prepared based on WHO recommendations such as TIP Flu and distributed to health care workers before the influenza vaccination season. The influenza vaccine supplied by national immunization program was monitored and reported to national level based on a framework and several prepared forms. Data were reported weekly on paper - based forms and processed and stored in an excel database. Results: Administration of influenza vaccine within the cardiovascular target group was ∼ 36% in 2016–2017, while in 2017–2018 season was increased to 42%, and in pregnant women from 0,5% in 2016–2017 to 1% in 2017–2018 season. Elderly above 60 years old are more interested in getting vaccinated against influenza and are the group with the higher administration percentage, in 2016–2017 season was 68,4% while in 2017–2018 season reached 69%. A positive trend was noticed on the vaccination coverage for health care workers from 60% in 2016–2017 to 72% in 2017–2018 season. Conclusion: During the last three years there is an increase commitment on influenza vaccination from government and other partners. Nevertheless, there is still need to keep influenza vaccination, among the priorities within the health agenda. The administration of influenza vaccine among target risk groups has been increased but remains very low among them due to lack of access to the vaccine. Meanwhile the well-functioning government influenza vaccination program of health care workers is showing good results.
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Influenza vaccination coverage among health-care personnel--United States, 2012-13 influenza season.
Routine influenza vaccination of health-care personnel (HCP) every influenza season can reduce influenza-related illness and its potentially serious consequences among HCP and their patients. To protect HCP and their patients, the Advisory Committee on Immunization Practices (ACIP) recommends that all HCP be vaccinated against influenza during each influenza season. To estimate influenza vaccination coverage among HCP during the 2012-13 season, CDC conducted an opt-in Internet panel survey of 1,944 self-selected HCP during April 1-16, 2013. This report summarizes the results of that survey, which found that, overall, 72.0% of HCP reported having had an influenza vaccination for the 2012-13 season, an increase from 66.9% vaccination coverage during the 2011-12 season. By occupation type, coverage was 92.3% among physicians, 89.1% among pharmacists, 88.5% among nurse practitioners/physician assistants, and 84.8% among nurses. By occupational setting, vaccination coverage was highest among hospital-based HCP (83.1%) and was lowest among HCP at long-term care facilities (LTCF) (58.9%). Vaccination coverage was higher for HCP in occupational settings offering vaccination on-site at no cost for one (75.7%) or multiple (86.2%) days compared with HCP in occupational settings not offering vaccination on-site at no cost (55.3%). Widespread implementation of comprehensive influenza vaccination strategies that focus on improving access to vaccination services is needed to improve HCP vaccination coverage. Influenza vaccination of HCP in all health-care settings might be increased by providing 1) HCP with information on vaccination benefits and risks for themselves and their patients, 2) vaccinations in the workplace at convenient locations and times, and 3) influenza vaccinations at no cost.
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Abstract Background To assess influenza vaccination coverage from 2001 to 2006 in Germany, to understand drivers and barriers to vaccination and to identify vaccination intentions for season 2006/07. Methods 9,990 telephone-based household surveys from age 14 were conducted between 2001 and 2006. Essentially, the same questionnaire was used in all seasons. Results The influenza vaccination coverage rate reached 32.5% in 2005/06. In the elderly (≥60 years), the vaccination rate reached 58.9% in 2005/06. In those aged 65 years and older, it was 63.4%. Perceiving influenza as a serious illness was the most frequent reason for getting vaccinated. Thirteen percent of those vaccinated in 2005/06 indicated the threat of avian flu as a reason. The main reason for not getting vaccinated was thinking about it without putting it into practice. The major encouraging factor to vaccination was a recommendation by the family doctor. 49.6% of the respondents intend to get vaccinated against influenza in season 2006/07. Conclusion Increasing vaccination rates were observed from 2001 to 2006 in Germany. The threat of avian influenza and the extended reimbursement programs may have contributed to the recent increase.
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