Comprehensive scRNA-seq Model Reveals Artery Endothelial Cell Heterogeneity and Metabolic Preference in Human Vascular Disease
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Objective To investigate the clinicopathological features of liver inflammatory pseudotumor (LIP). Methods The pathological features of the samples extracted from 37 cases of LIP between June 1994 and April 2000 in our hospital were analyzed and discussed. Results Of the 37 patients, 25 (67.6%) had no any symptom. The disease also had its won special pathological features. Conclusions LIP is usually misdiagnosed as other tumors because it is uncommon. Pathological examination is the only means to obtain the final diagnosis. Therefore, its clinicopathological features are of special value for clinical and pathological doctors.
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Objective To study the relationship between pathological changes and pathological grades of cervical spondylotic myclopathy (CSM) .Methods 120 intervertebral discs of patients with CSM in varions pathological grades were resected,divided into fibrous annulus and pulpiform nucleus, stained with hematoxylin - eosin.and observed under microscope. The pathological changes found in the intervertebral discs were clasestied into 7 indices,and analyzed statistically.Results Patients with different pathological grades of CSM had relevant pathological changes in intervertebral discs. Conclusions There is significant relationship between the pathological changes and grades of CSM, and also belween the indices of pathological changes in interveitebral discs.
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AbstractThis paper reviews research conducted on the link between pathological gambling and substance misuse. We first examine the phenomenon of "pathological gambling," including similarities between pathological gambling and substance misuse, instruments used to measure pathological gambling, and the prevalence of pathological gambling in the United States and internationally. We then examine research on substance misuse among pathological gamblers, pathological gambling among substance misusers, and the treatment of the pathological gambler-substance misuser. We conclude with a discussion of future research needs.Key Words: Pathological gamblingSubstance misuseLiterature review
Substance misuse
Gambling disorder
Impulse control disorder
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Objective To explore the relationship between C-reactive protein and pathological changes of coronary artery.Methods One hundred and fifty-three patients who had no myocardial infarction,cardiac failure,injury,infection and cancer etc,and were approved by CAG were selected.The patients were retrospected in this study.Forty-three cases of the control group were normal coronary artery,39 cases with single vessel pathological changes,32 cases double vessel pathological changes,and 39 cases three vessel pathological changes,which were defined as single,double and three group respectively.The levels serum CRP of all patients were detected within 24 hours. Results There were significant differences among four groups. CRP levels of coronary heart disease were higher than that of control group.Serum CRP levels in three vessel pathological changes were higher than double vessel pathological changes and much higher than single vessel pathological changes. Conclusion Levels of serum CRP is correlated with pathological degree of coronary artery.
Coronary atherosclerosis
Coronary arteries
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Objective To estimate the effectiveness of fluoxatine treatment in patients with pathological crying and pathological laughing after brain stroke. Methods Seventeen pathological crying patients and 14 pathological crying with pathological laughing patients were included and was treated with fluoxatine (20 mg/d) for 4 weeks in this study. Results Fluoxatine is effective in the treatment of both pathological crying and laughing,but the efficacy in pathological crying is better than that in pathological laughing patients. Although HAMD scale(17 items) in most of these patients was higher than 17 scores,the improvement in emotional lability was independent on depression status. Conclusions 5-serotonine system might play an important role in pathological crying and laughing after stroke. It remains unclear whether the anatomic basis and pathogenesis of pathological crying and laughing is same.
Stroke
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Objective To study the relationship between the clinical and pathological characteristics in children patients with Henoch-SchSnlein purpura nephritics(HSPN).Methods We retrospectively reviewed the information of Clinical and pathological of 68 children with HSPN from January to July in 2009.Results A majority of patients exhibited hematuria,proteinunia,isolated hematuria and nephrotic syndrome while a minority showed the rapidly progressive glomerulonephritis.The pathological performs were mesangical proliferation,glomerulosclerosis and crescent formation.Most of pathological classifications were gradeⅡ or Ⅲ.Conclusions Grade Ⅱand Ⅲ of pathological classification have been seen in the majority of HPSN patients,and the clinical manifestations were closely associated with pathological classification.
Purpura (gastropod)
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The preoperative and postoperative changes and clinical value of serum IGF-1 in lung cancer patients
Objective To observe the changes of serum IGF-1 in lung cancer patients before and after operation,so as to explore the clinical value to operation effect and postoperative surgico-pathological stating.Methods The serum IGF-1 in 38 lung cancer patients were detected before and after operation by radioimmunoassay,as well as in 36 normal controls.The variation of serum IGF-1 before and after operation were analyzed,and the relations of IGF-1 and pathological type and postoperative surgico-pathological stating were evaluated.Results The serum IGF-1 in lung cancer patients were significantly higher than normal people(P0.01).Compared with those of preoperation,the level of serum IGF-1 decreased dramatically after operation for two weeks(P0.01).There were not obvious differences in the patients with different pathological type(P0.05).But there were significant differences in the patients with different postoperative surgico-pathological stating(P0.05).Conclusion Detection of serum IGF-1 was helpful to judge the operation effect and postoperative surgico-pathological stating of lung cancer.
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Study on pathological diagnosis of pathological changes of 457 patients with atypical squamous cells
Objective To discuss the pathological diagnosis of pathological changes.Methods The 457 patients with pathological changes of cervical atypical squamous cells were further investigated by colposcope and multiple cervical biopsies for pathological analysis.Results The rates of cervical epitheilial neoplasma II(CINⅡ) of ASC-US and ASC-H were 8.15%(34/417) and 35%(14/40),showing significant defferences between the two groups(P0.01).Conclusion Pathological analysis be carried out for early diagnosis of cervical epithelial neoplams.
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Objective To explore the clinical and pathological features,and the correlation between clinical and pathological diagnoses in 1 000 children with renal biopsies.Methods In 1 000 children with renal diseases,the renal biopsies were performed using semi automatic biopsy needles under ultrasound guidance.The clinical and renal pathological data were analyzed retrospectively.Results In 96.2%(n = 962)of cases,renal biopsies were obtained successfully.Mild complications occurred in 17% patients(n = 170).Most of clinical manifestations were consistent to pathological diagnosis,but 20 cases were not.Conclusions There was considerable proportion of patients who were misdiagnosed and had excessive treatment or delayed treatment for pediatric renal diseases if diagnosed only by clinical manifestation.The pathological diagnosis provides guidances and significantly improves clinical treatment and prognostic assessment.
Renal pathology
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Make the use of B physical gallbladder for pathological changes of physical gallbladder.By the contrast of the operation and pathological changes analyse and have a discussion.We can see that the pathological changes of bulging pathological changes are different from pathological changes and the representation of sounds and pictures.Conclusion:the percent of ultrasonic exam for bulging pathological changes has reached over 90 percent and it has no wounds and have a repetition.At present the sensibility is the first among the method of diagnose of sounds and pictures.
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