The worthy role of hepatic arterial infusion chemotherapy in combination with anti-programmed cell death protein 1 monoclonal antibody immunotherapy in advanced hepatocellular carcinoma
Yixin DingShasha WangZhenkang QiuChunyang ZhuYan WangZhao Shu-fenWensheng QiuKongjia WangJing LvWeiwei Qi
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Abstract:
Systemic therapy remains the primary therapeutic approach for advanced hepatocellular carcinoma (HCC). Nonetheless, its efficacy in achieving control of intrahepatic lesions is constrained. Hepatic arterial infusion chemotherapy (HAIC) is a therapeutic approach that combines localized treatment with systemic antitumor effects, which aim is to effectively manage the progression of cancerous lesions within the liver, particularly in patients with portal vein tumor thrombosis (PVTT). Combining HAIC with anti-programmed cell death protein 1 (anti-PD-1) monoclonal antibody (mAb) immunotherapy is anticipated to emerge as a novel therapeutic approach aimed at augmenting the response inside the localized tumor site and achieving prolonged survival advantages. In order to assess the effectiveness, safety, and applicability of various therapeutic modalities and to address potential molecular mechanisms underlying the efficacy of HAIC-sensitizing immunotherapy, we reviewed the literature about the combination of HAIC with anti-PD-1 mAb therapies.Keywords:
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Objective To investigate the therapeutic effects of intracapsular injection with Pingyangmycin on recurrent laryngeal cysts based on a clinical study. Methods Included in this study were 39 cases with recurrent laryngeal mucous cyst, treated by 0.2% Pingyangmycin injected intracapsularly under indirect or direct laryngoscope to approach the cyst with mucosal surface anesthesia, once a month and twice as a therapeutic course. Results Among these 39 cases, 27 were treated only one therapeutic course, 3 were given two therapeutic courses and one received 3 therapeutic courses in this way. In the other hand, 35 Patients were completed this kind of treatment under indirect laryngoscope and 4 were Performed such a Procedure under direct laryngoscope. By the end of following up Period, 36 cases were found cured and the other 3 were shown significantly effective, all with no significant side effects found either during the therapeutic course or after the treatment. Conclusions This therapeutic Procedure with 0.2% Pingyangmycin injected intracapsularly under mucosal surface anesthesia is capable of exposing the cyst clearly, being Performed much simply and being uneasy with the lesion reoccurred, and it can be taken as an effective therapy for the treatment of recurrent laryngeal cysts.
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Objective To explore an effective therapy for the treatment of sensorineural hearing loss(SNHL). Methods 302 cases(342 ears)with SNHL were randomly divided into two groups,i. e. treating group(TG) treated with a combining therapy induing meteria medica on the basis of syndrome differentiation and treatment and controlling one(CG) treated only with ligustrazine given intramuscularly. Then,the therapeutic effects were compared between them by the end of therapy. Results The total effective rate was 67% in TG, significantly higher than that of CG(32. 5%). However, there was no significant correlation of therapeutic effects with clinical patterns of this lesion. Conclusion The combining therapy with syndrome differentiation and treatment is very effective for the treatment of SNHL.
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Objective:To investigate the therapeutic effects and therapeutic mechanism of combined treatment of Shengjing Yusi Capsule(SYC)and antibiotics in infertility caused by chronic prostatitis(CP).Methods:All 98 infertility patients with CP were randomly divided into two groups:the control group(48 cases)were treated with antibiotics(western medicine)and the therapeutic group(50 cases)were treated with antibiotics and SYC(traditional Chinese medicine TCM)simultaneously,both groups were treated for 3~6 months.The indexes of seminal,prostatic fluid(EPS)and the scores of NIH-CPSI were observed before and after treatment.Results:The total effective rate of the therapeutic group was 96%,and which of the control group was 77.08%,it was meant the therapeutic effect of the therapeutic group was obviously superior to the control group(P0.01).In the two groups patients' seminal quality were improved significantly.The indexes of EPS and scores of NIH-CPSI of the therapeutic group were better than those of the control group(P0.01).Conclusion:The SYC combined with antibiotics could significantly increase the therapeutic effects in patients with infertility caused by CP.It suggested that the combined treatment of TCM and western medicine can treat in many ways focusing on relieving both the secondary and primary symptoms,and superimposing therapeutic effects.The combined treatment of TCM and western medicine is superior to single antibiotic treatment.
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Objective To study the therapeutic effect of gangliosides injection on radiation encephalopathy(REP).Methods Forty patients with REP after radiotherapy for nasopharyngeal carcinoma were divided into experimental(conventional therapy combined with gangliosides) and the controls(conventional therapy only) groups randomly.The clinical therapeutic outcomes were observed and compared in the 2 groups.Results The therapeutic outcomes were better in the experimental group than that between the control group obviously(P0.05).Conclusion Gangliosides has an obvious therapeutic effect on REP.
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To approachs the main factors of impacting therapeutic effect with acupuncture in the treatment of essential dysmenorrhea, basing on related literature for about then years. According to the physiology, pathology and mental state of the patient, basing on the rhythmicity of menstrual cycle, combining the factors of impacting therapeutic effect with acupuncture in the treatment of essential dysmenorrhea, treating the excess syndrome by purgation while treating the deficient syndrome by tonification, making to personal treatment. So therapeutic effect could be elevated.
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Objective:To Investigate the therapeutic effects and the prognosis of diffuse axonal injury(DAI).Methods:Seventy-five patients with DAI who were admitted to our department from Jan.1998 to Dec.2003 were divided at random into two groups,the therapeutic group(n=35) and the control group(n=40).The patients in the therapeutic group were suffered to the general therapeutic measures,combined with other measures including Nimodipine,Naloxone,moderate hypothermia and hyperbaric oxygenation.The patients in the control group were treated with the general therapeutic measures only.Results:According to the standards of GOS prognosis,the mortality rate of the patients in the therapeutic group(42.9%) was much lower than that of the patients in the control group(60%),and the recovery rate of the therapeutic group patients(25.7%) was much higher than that of the control group patients(15%).There was significant difference in mortality and recovery rate between the two groups by X2 test(P0.05).Conclusion:The therapeutic method of multi-measures may play the key role in improving the clinical outcomes for DAI,and it can significantly decrease the mortality of the patients with DAI.
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Objective:To investigate therapeutic effects of hyperbaric oxygen(HBO) and brevisapin on diabetic peripheral neuropathies(DPN).Methods:Sixty-five patients with DPN enrolled in this study were randomly divided into a therapeutic group(n=35) and control group(n=30).The therapeutic group received HBO in combination with brevisapin,the control group were given single HBO therapy.The symptoms and nerve conduction velocity(NCV) of these groups were compared after treatment.Results:Thrity-two effective examples in therapeutic group,had efficiency of 91.43%,19 effective examples in control group had efficiency 63.33%.The effective was significantly higher in therapeutic group than that in control group(χ2 = 7.54,P0.01),the increase of NCV in therapeutic group was higher than that in control group.Conclusion:HBO combined with brevisapin on diabetic peripheral neuropathy has a better therapeutic effect.
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To observe the therapeutic effect and pulmonary function of 30 childhood asthma patients after treated with integration of Chinese and western medicine therapy.Dividing 60 cases into 2 groups randomly,the treatment group was treated with natural herbs and corticosteroid inhalation, while the control group was treated only with the latter.3 months made one coure of treatment.The therapeutic effect was observed and the maximum exploratory flow was determined before and after treatment.It was showed that the therapeutic effect of treatment group was better than control group(P0.05),there was significant difference of the MEF between the two groups.It can be said that treating childhood asthma with integration of Chinese and western medicine therapy has good therapeutic effect,lower side effect and can enhance pulmonary function.
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Objective To approach the clinical value of ultraselection embolism combined with therapeutic endoscopy.Methods 22 cases patients diagnosed as JNA were divided into 13 cases of therapeutic alliance group and 9 cases of exairesis group,and collect the mean volume of blood loss,transfusion volume and operation time.Results In therapeutic alliance group,the mean volume of blood loss and transfusion volume is(400±200)mL and(350±250)mL,but the volume is(1210±400)mL and(1180±500)mL in exairesis group.On the other hand,the operation time in therapeutic alliance group and exairesis group are(95±10)min and(145±20)min.Conclusion There are certain curative effect by ultraselection embolism combined with therapeutic endoscopy to JNA,and it can decrease the blood loss and operation time,and it's easy working and cheaper.The therapeutic alliance method is a effective treatment,and is valuable to promote in clinic.
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ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA ZIMNOCH N, PERMODA A. Therapeutic treatment in the treatment of lower back pain â Part II - Treatment and proper therapeutic/training procedure. Physiotherapy Review. 2020;24(3):11-24. doi:10.5114/phr.2020.102998. APA ZIMNOCH, N., & PERMODA, A. (2020). Therapeutic treatment in the treatment of lower back pain â Part II - Treatment and proper therapeutic/training procedure. Physiotherapy Review, 24(3), 11-24. https://doi.org/10.5114/phr.2020.102998 Chicago ZIMNOCH, Natalia Julia, and Andrzej PERMODA. 2020. "Therapeutic treatment in the treatment of lower back pain â Part II - Treatment and proper therapeutic/training procedure". Physiotherapy Review 24 (3): 11-24. doi:10.5114/phr.2020.102998. Harvard ZIMNOCH, N., and PERMODA, A. (2020). Therapeutic treatment in the treatment of lower back pain â Part II - Treatment and proper therapeutic/training procedure. Physiotherapy Review, 24(3), pp.11-24. https://doi.org/10.5114/phr.2020.102998 MLA ZIMNOCH, Natalia Julia et al. "Therapeutic treatment in the treatment of lower back pain â Part II - Treatment and proper therapeutic/training procedure." Physiotherapy Review, vol. 24, no. 3, 2020, pp. 11-24. doi:10.5114/phr.2020.102998. Vancouver ZIMNOCH N, PERMODA A. Therapeutic treatment in the treatment of lower back pain â Part II - Treatment and proper therapeutic/training procedure. Physiotherapy Review. 2020;24(3):11-24. doi:10.5114/phr.2020.102998.
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