logo
    Effect of BRAF mutation on the prognosis for patients with colorectal cancer undergoing cytoreductive surgery for synchronous peritoneal metastasis
    Gastroenterology report (2022)
    Zhijie WuXiusen QinYuanxin ZhangJian LuoRui LuoZonglu CaiHui Wang
    0
    Citation
    42
    Reference
    10
    Related Paper
    Abstract:
    KRAS/BRAF mutations (mutKRAS/mutBRAF) are unfavorable prognostic factors for colorectal cancer (CRC) metastases to the liver and lungs. However, their effects on the prognosis for patients with synchronous peritoneal metastasis (S-PM) of CRC after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are controversial. In the study, we aimed to determine the effects of mutKRAS/mutBRAF on the prognosis for patients with S-PM who received CRS.A total of 142 patients diagnosed with S-PM between July 2007 and July 2019 were included in this study. The demographics, mutKRAS/mutBRAF status, overall survival (OS), and progression-free survival (PFS) of the patients were evaluated. The Kaplan-Meier method and log-rank test were used to estimate the difference in survival between groups.Among 142 patients, 68 (47.9%) showed mutKRAS and 42 (29.5%) showed mutBRAF. The median OS values were 8.4 and 34.3 months for patients with mutBRAF and BRAF wild-type, respectively (P < 0.01). However, KRAS status was not significantly associated with median OS (P = 0.76). Multivariate analysis revealed carcinoembryonic antigen, CRS, HIPEC, and mutBRAF as independent predictors for OS. Based on these findings, a nomogram was constructed. The C-index was 0.789 (95% confidence interval, 0.742-0.836), indicating good predictive ability of the model. Furthermore, the 1- and 2-year survival calibration plots showed good agreement between the predicted and actual OS rates. The area under curves of the 1- and 2-year survival predictions based on the nomogram were 0.807 and 0.682, respectively. Additionally, mutBRAF was significantly associated with lower PFS (P < 0.001).mutBRAF is an independent prognostic risk factor for S-PM. The established nomogram predicted the OS of patients with CRC having S-PM with high accuracy, indicating its usefulness as a valuable prognostic tool for the designated patient cohort.
    Keywords:
    Nomogram
    Carcinoembryonic antigen
    Hyperthermic Intraperitoneal Chemotherapy
    Log-rank test
    Topics:
    Intraperitoneal and Appendiceal Malignancies
    Hepatocellular Carcinoma Treatment and Prognosis
    Renal cell carcinoma treatment
    PDF
    The Impact of Enhanced Recovery Protocol (ERAS) In Peritoneal Surface Malignancies Managed with Cytoreductive Surgery & Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Multicentric Collaboration
    European Journal of Surgical Oncology (2023)
    Wael GawadNader HannaHany F. MoustafaGamal AmiraMohga Samy
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Citations (0)
    02 / Postoperative outcomes of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC)
    Fumiyo Yasuma
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Citations (0)
    323. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Risk factors for morbidity and postoperative outcome
    European Journal of Surgical Oncology (2016)
    Manuela RobellaMarco VairaMichele De Simone
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Citations (0)
    Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases in patients with colorectal cancer
    Cochrane library (2021)
    Lieke G.E.M. RazenbergSimon W. NienhuijsYvonne L.B. KlaverMisha LuyerGeert-Jan Creemers
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Citations (0)
    Morbidity, mortality and long-term survival in patients undergoing extended cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
    European Journal of Surgical Oncology (2012)
    Daniela ZamboninCarmela Di MartinoStefano ScaringiBenedetta PesiF Tonelli
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Citations (0)
    Short-term morbidity and mortality associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent/advanced-stage ovarian cancer
    Gynecologic Oncology (2014)
    J.C. CripeJu-Yu TsengR. EskanderSharon ThompsonAmanda N. Fader
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Fallopian tube
    Citations (0)
    Surgical morbidity and mortality in patients undergoing extended cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
    European Journal of Surgical Oncology (2012)
    Daniela ZamboninCarmela Di MartinoStefano ScaringiBenedetta PesiGiacomo Batignani
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Citations (0)
    Health-related quality of life after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is not different than cytoreductive surgery alone in primary ovarian cancer patients (009)
    Gynecologic Oncology (2023)
    Vadim GushchinArmando SardiMary Caitlin KingAndrei NikiforchinFelipe Lopez-Ramirez
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Citations (0)
    Treatment and Survival Outcomes of Patients with Colorectal Peritoneal Metastases deemed Ineligible for Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
    European Journal of Surgical Oncology (2023)
    Michelle V. DietzMerijn ZiekmanJob van kootenAlexandra R. M. Brandt‐KerkhofEsther van Meerten
    Hyperthermic Intraperitoneal Chemotherapy
    Intraperitoneal Chemotherapy
    Citations (0)
    Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Mesothelioma; a prospective study
    European Journal of Surgical Oncology (2008)
    Faheez MohamedHideaki YanoTom CecilBrendan Moran
    Hyperthermic Intraperitoneal Chemotherapy
    Citations (1)