Microwave ablation versus laparoscopic resection for hepatocellular carcinoma in patients with clinically significant portal hypertension: a propensity score–matched study of postoperative liver decompensation
Hongli YuFenglin ZhaoXiaoxiao MenHuaqiang ZhuJingrui YanZongxin LiuQiqi LiuYuemin FengLe WangMin MengQiang ZhuXinya Zhao
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Keywords:
Decompensation
Microwave ablation
Microwave ablation
Ablation zone
Thermal ablation
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(1) Background: Percutaneous microwave ablation (MWA) is an accepted treatment of non-operative liver cancer. This study compares the ablation zones of four commercially available 2.45 GHz MWA systems (Emprint, Eco, Neuwave, and Solero) in an ex vivo porcine liver model. (2) Methods: Ex vivo porcine livers (n = 85) were obtained. Two ablation time setting protocols were evaluated, the manufacturer’s recommended maximum time and a 3 min time, performed at the manufacturer-recommended maximum power setting. A total of 236 ablation samples were created with 32 (13.6%) samples rejected. A total of 204 samples were included in the statistical analysis. (3) Results: For single-probe protocols, Emprint achieved ablation zones with the largest SAD. Significant differences were found in all comparisons for the 3 min time setting and for all comparisons at the 10 min time setting except versus Neuwave LK15 and Eco. Emprint produced ablation zones that were also significantly more spherical (highest SI) than the single-probe ablations from all other manufacturers. No statistical differences were found for ablation shape or SAD between the single-probe protocols for Emprint and the three-probe protocols for Neuwave. (4) Conclusions: The new Emprint HP system achieved large and spherical ablation zones relative to other 2.45 GHz MWA systems.
Microwave ablation
Ablation zone
Ex vivo
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Objectives The aim of this study was to compare the differences between the ablation region and hyperechoic zones in microwave and radio frequency ablation of different tissues. Methods Microwave and radio frequency ablation were performed on fresh porcine muscle and liver with different power levels for 90 seconds. These 2 ablation methods were then performed on rabbit liver in vivo using 20 W for 60 seconds. The volumes of the ablation and hyperechoic zones were compared following different ablation methods. Results The ablation zones were significantly greater than the hyperechoic zones ( P < .05) with the same power and duration when using 2 ablation methods. The differences of the ablation and hyperechoic zones between muscle and liver tissues were significantly different ( P < .05). The difference values of the ablation and hyperechoic zones were also significantly different ( P < .05) using 2 ablation methods. Conclusions The hyperechoic zone may have underestimated the extent of ablation using a specified ablation time. In the same tissue, the hyperechoic zone could more accurately estimate the ablation zones using microwave ablation.
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Microwave ablation
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Decompensation
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Microwave ablation
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To investigate the efficacy and safety of percutaneous microwave ablation.Twenty-six rabbits with lung VX2 tumor were randomly divided into experimental and control group. In the experimental group, microwave ablation guided by ultrasound or CT was performed based on location of the tumor. Enhanced CT scan was carried out immediately before and after the ablation for all animals. Two animals from each group were sacrificed immediately or 1 week after the ablation respectively and the others were followed for the rest of their lives.CT scan revealed that the tumor was greatly reduced or ablated after ablation. Pathological examination immediately after ablation also confirmed the tumor reduction or ablation. The survival time of the animals in the experimental group was significantly longer than that in the control group.Microwave ablation is a safe and effective method for treating lung cancer in rabbits, showing potential clinical applicability.
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Microwave thermal ablation is under investigation for minimally invasive treatments. In the cases of small targets, such as adrenal glands, microwave thermal ablation is a valuable alternative to the traditional and more invasive treatments (e.g. surgical procedures, pharmaceutical therapies). In this work, ablation treatments are carried out on ex-vivo liver samples using a custom developed microwave ablation applicator for ablation of small targets. Ablation zones achieved with different treatment settings are analysed. The power and time settings suitable to achieve a small and well controlled ablation zone, are evaluated. Moreover, the temperature increase in different regions of the area under treatment is assessed.
Microwave ablation
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Ex vivo
Thermal ablation
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Microwave ablation
Wedge (geometry)
Ablation zone
Tumor ablation
Liver tumor
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