Change in Therapeutic Approach after PET/TC PSMA-18F DCFPyL in Occult Biochemical Recurrence of Prostate Carcinoma with Low PSA Values
F. AmorelliP. PlazaP. ForoAlvaro A. MartinezF. LiuNúria RodríguezI. MembriveRaquel Valhondo-RamaJavier Martínez‐SanzM. AlgaraA. ReigJ. QueraAndrea NataliJose M. Torices
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Objective:To explore the expression and significance of signal transducer and activator of transcription 3(STAT3) in prostate carcinoma tissues.Methods:The expression of STAT3 in 40 cases of prostate carcinoma tissues and 12 cases of normal prostate tissue was detected by immunohistochemical staining.Results:The positive rate of the expression of STAT3 in prostate carcinoma was 87.5%,and was significantly higher than 41.7% in the normal prostate tissue,there was a significant difference between two groups(P0.01).STAT3 expression levels were closely related to the pathological grade of prostate cancer.Conclusion:Compared with the normal prostate tissue,the expression level of STAT3 in prostate carcinoma is significantly higher.It suggests that the expression of STAT3 may be related to the risk and develop-ment of prostate carcinoma.
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Summary. The third case of a culturally and histologically proven candidosis of the prostate in the world literature available to us is reported. Autopsy of a 59‐year‐old man with metastasizing bronchial carcinoma as predisposing primary disease revealed a local candidosis of the prostate in the left lobe of the prostate, without evidence of a Candida sepsis. Parallel and different aspects in comparison with the other two cases are described. Zusammenfassung. Der dritte Fall in der Weltliteratur einer kulturell und histologisch gesi‐cherten Prostata‐Candidose wird beschrieben. Die Obduktion eines 59‐jährigen Mannes mit metastasierendem Bronchialcarcinom als prädis‐ponierende Grunderkrankung ergab eine lokale Prostata‐Candidose im linken Prostatalappen, ohne Hinweise für eine Candida‐Sepsis . Parallelen und Unterschiede zu den zwei weiteren Kasuisti‐ken werden dargestellt.
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Occult practices have occurred since time immemorial, and even today occult practices cannot be separated from the lives of believers and humans in general. What are occult practices and how can occult practices occur and what are the impacts on human life. In this paper, the author will explain the biblical view of the occult and its ins and outs so that believers can know and be able to avoid various kinds of occult practices that are around us.
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This chapter presents the polarizing reactions to occult thinking—while some considered it a legitimate source of knowledge, others saw it as diabolical and taboo—and shows how prophecy that drew on occult sources suffered anathematization by established authorities. The discussion of occult philosophy in the late seventeenth century was muddled, and the occult was erroneously presented as a defining feature of witchcraft. Witchcraft, although tangential to occult beliefs, became a tool that was frequently used to disparage occult philosophy. It is argued here, however, that one could deny witchcraft and believe in occult philosophy, and vice versa. The final sections of the chapter discuss the attempts of scientific thinkers in testing occult claims and the pursuit of hidden knowledge or secrets.
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Conventional imaging techniques have serious limitations in the detection, staging, and restaging of prostate carcinoma. Anti-1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid (anti-(18)F-FACBC)is a synthetic l-leucine analog that has excellent in vitro uptake within the DU-145 prostate carcinoma cell line and orthotopically implanted prostate tumor in nude rats. There is little renal excretion compared with (18)F-FDG. The present study examines anti-(18)F-FACBC uptake in patients with newly diagnosed and recurrent prostate carcinoma.Fifteen patients with a recent diagnosis of prostate carcinoma (n = 9) or suspected recurrence (n = 6) underwent 65-min dynamic PET/CT of the pelvis after intravenous injection of 300-410 MBq anti-(18)F-FACBC followed by static body images. Each study was evaluated qualitatively and quantitatively. Maximum standardized uptake values were recorded in the prostate or prostate bed, and within lymph nodes at 4.5 min (early) and 20 min (delayed), and correlated with clinical, imaging and pathologic follow-up. Time-activity curves were also generated for benign and malignant tissue.In the 8 patients with newly diagnosed prostate carcinoma who underwent dynamic scanning, visual analysis correctly identified the presence or absence of focal neoplastic involvement in 40 of 48 prostate sextants. Pelvic nodal status correlated with anti-(18)F-FACBC findings in 7 of 9 patients and was indeterminate in 2 of 9. In all 4 patients in whom there was proven recurrence, visual analysis was successful in identifying disease (1 prostate bed, 3 extraprostatic). In 3 of these patients, (111)In-capromab-pendetide had no significant uptake at nodal and skeletal foci. Malignant lymph node uptake in both the staging and restaging patients was significantly higher than benign nodal uptake. Though uptake faded with time, in all 6 patients with either lymph node metastases or recurrent prostate bed carcinoma, there was intense persistent uptake at 65 min.Anti-(18)F-FACBC is a promising radiotracer for imaging prostate carcinoma. Radiotracer uptake was demonstrated in primary and metastatic disease. Future research should investigate the mechanism of radiotracer uptake in normal and pathologic tissue and develop a clinical imaging strategy for initial staging and restaging.
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Objective:To explore the MRI appearances and improve the recognition of occult fracture.Methods:MRI and other imaging data of 31 patients with negative performance on plain X-ray films were retrospectively analysed.Results:In 31 injuried patients,the conventional X-ray films showed no obvious change.Among them,conventional CT scanning of 11 cases also showed no abnormal signs,7 cases were suspicious of having fracture after performed with MPR,MRI imagings of all 31 cases showed abnormal signal change and were diagnosed occult fracture.Conclusions:For injuried patients who are suspicious of having clinical occult fracture,MRI examination should be the first choice and it has high sensitivity in diagnosing occult fracture.
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Endoscopic repair of groin hernias allows the surgeon to have a complete view of the groin and pelvis to diagnose occult hernias both ipsilaterally and contralaterally. These occult hernias can then be treated simultaneously and may reduce the incidence of recurrence and persistent symptoms. The authors present four unusual cases where occult hernias were found ipsilaterally during an endoscopic repair. All these occult hernias were treated along with the clinically diagnosed hernia at the same surgery with excellent results and no post-operative morbidity.
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