The Academic Impact of Congenital Heart Surgeons’ Society (CHSS) Studies
Jeffrey P. JacobsWilliam M. DeCampliTara KaramlouHani K. NajmBradley S. MarinoEugene H. BlackstoneBrian W. McCrindleAnusha JegatheeswaranJames D. St. LouisErle H. AustinChristopher A. CaldaroneConstantine MavroudisDavid M. OvermanJoseph A. DearaniMarshall L. JacobsChristo I. TchervenkovLars G. SvenssonDavid J. BarronJames K. KirklinWilliam G. Williams
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Abstract:
We reviewed all 64 articles ever published by The Congenital Heart Surgeons' Society (CHSS) Data Center to estimate the academic impact of these peer-reviewed articles.The Congenital Heart Surgeons' Society has performed research based on 12 Diagnostic Inception Cohorts. The first cohort (Transposition) began enrolling patients on January 1, 1985. We queried PubMed to determine the number of publications that referenced each of the 64 journal articles generated by the datasets of the 12 Diagnostic Inception Cohorts that comprise the CHSS Database. Descriptive summaries of the data were tabulated using mean with standard deviation and median with range.Sixty-four peer-reviewed papers have been published based on the CHSS Database. Fifty-nine peer-reviewed articles have been published based on the 12 Diagnostic Inception Cohorts, and five additional articles have been published based on Data Science. Excluding the recently established Diagnostic Inception Cohort for patients with Ebstein malformation of tricuspid valve, the number of papers published per cohort ranged from 1 for coarctation to 11 for transposition of the great arteries. The 11 articles generated from the CHSS Transposition Cohort were referenced by a total of 111 articles (median number of references per journal article = 9 [range = 0-22, mean = 10.1]). Overall, individual articles were cited by an average of 11 (mean), and a maximum of 41 PubMed-listed publications. Overall, these 64 peer-reviewed articles based on the CHSS Database were cited 692 times in PubMed-listed publications. The first CHSS peer-reviewed article was published in 1987, and during the 35 years from 1987 to 2022, inclusive, the annual number of CHSS publications has ranged from 0 to 7, with a mean of 1.8 publications per year (median = 1, mode = 1).Congenital Heart Surgeons' Society studies are widely referenced in the pediatric cardiac surgical literature, with over 10 citations per published article. These cohorts provide unique information unavailable in other sources of data. A tool to access this analysis is available at: [https://data-center.chss.org/multimedia/files/2022/CAI.pdf].Aims
The aim of this report is to use the GO-CHILD birth cohort to map the prevalence of atopic diseases in children in the UK at 1 year.Methods
GO–CHILD is a multicentre prospective birth cohort study. 2135 infants were recruited antenatally and followed up by questionnaires to determine the prevalence of infections and atopic symptoms at 3, 6, 12 and 24 months. The 12 month questionnaire ascertains atopic symptoms within the first year of life.Results
From the 1226 1 year questionnaires that have been received, 1123 had been entered and analysed by 3/12/2014. 351 (31%) children had eczema and of these 169 (48%) had this condition for over 6 months. 176 (16%) had experienced dry cough unrelated to infection and 253 (23%) had experienced wheeze. Of those reporting wheeze, 243 (96%) had developed the wheeze during or soon after a viral infection, 161 (60%) had been prescribed salbutamol, 97 (39%) had attended their GP as an emergency and 47 (19%) had been admitted to hospital. 523 (47%) of the children were reported to snore at night and 252 (22%) had a runny or blocked nose unrelated to infection: both symptoms are potentially indicators of allergic rhinitis. 187 (17%) reported a reaction to a food item, of which the most common was cow’s milk.Conclusion
These interim results show a high prevalence of wheeze, eczema and nasal symptoms in 1 year old children. These data are in line with previous cohort studies. The Manchester Asthma and Allergy Study (MAAS) showed the prevalence of eczema to be 37% and wheeze to be 28% at 1 year. The ALSPAC study found the prevalence of eczema and wheeze to be 25.6% and 23% respectively between 6 and 18 months of age. However our study shows higher levels of upper respiratory symptoms than MAAS which showed a prevalence of 1–2% by 1 year. This study was funded by SPARKS.Wheeze
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Congenital heart disease in neonates: Their clinical profile, diagnosis, and their immediate outcome
Background: Congenital heart disease (CHD) occurs in approximately 0.6%–0.8% of live births. Early recognition of CHD is important for appropriate management and decision-making regarding referral. The purpose of this study was to document the common presenting symptoms and signs in the neonates with CHD, definitive diagnosis, and their outcome.Materials and Methods: The study was conducted prospectively in Neonatal Intensive Care Unit, G.B Pant Children Hospital, Department of Pediatrics and Neonatology, GMC Srinagar, from January 2016 to January 2018. Echocardiography screening of all neonates suspected of having CHD was done. Details of all neonates having CHD diagnosed by echocardiography were noted in the prescribed pro forma and their incidence, clinical profile, and outcome were studied.Results: Totally 529 cases of CHD diagnosed by echocardiography in the neonatal period were studied, out of which 280 were male and 259 were female (male:female = 1.12:1). 382 (72.2%) had acyanotic CHD and 147 (27.7%) had cyanotic CHD (CCHD). Among the acyanotic CHD, the most common CHD was ventricular septal defects (n = 170, 32.1%), and among cyanotic group, d-transposition of great arteries was most common (n = 41, 7.75%). Majority of CCHDs were diagnosed in 1st week of life (n = 50, 34.01%) and most of the neonates with acyanotic CHD were diagnosed in the 4th week of life (n = 207, 39.1%). The most common presenting problem of neonates was fast breathing 230 (43.4%) followed by feeding difficulty 110 (20.77%), cyanosis 91 (17.2%), shock manifested as decreased urine output (n = 43, 8.1%), 43 neonates (8.1%) had cyanosis along with fast breathing, and 32 neonates (6.04%) presented with murmur only. Sixty neonates (40.8%) with CCHD expired within the neonatal period.Conclusion: Neonates with CHD have a unique presentation and they carry a poor outcome unless diagnosed early and managed appropriately. Infants presenting with multiple anomalies should be screened for any underlying structural heart disease. High index of suspicion is very important as many neonates with CHD are asymptomatic initially.
Neonatology
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Little is known about the growth of VLBW infants in South Africa. The aim of this study was to assess the growth of a cohort of VLBW infants in Johannesburg.A secondary analysis of a prospective cohort was conducted on 139 VLBW infants (birth weight ≤ 1500 g) admitted to Charlotte Maxeke Johannesburg Academic Hospital. Growth measurements were obtained from patient files and compared with the World Health Organization Child Growth Standards (WHO-CGS) and with a previous cohort of South African VLBW infants. The sample size per analysis ranged from 11 to 81 infants.Comparison with the WHO-CGS showed initial poor growth followed by gradual catch up growth with mean Z scores of 0.0 at 20 months postmenstrual age for weight, -0.8 at 20 months postmenstrual age for length and 0.0 at 3 months postmenstrual age for head circumference. Growth was comparable with that of a previous cohort of South African VLBW infants in all parameters.Initial poor growth in the study sample was followed by gradual catch up growth but with persistent deficits in length for age at 20 months postmenstrual age relative to healthy term infants.
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Using data on weight and height at 6 and 11 months of age and primary care electronic health records data from 1960 children participating in the Wheezing Illnesses Study Leidsche Rijn birth cohort study, we found that body mass index at 6 and 11 months of age was not associated with otitis media occurrence during the first 4 years of life.
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Background: Atrial Fibrillation (AF) ablations are performed in pts of all age groups. No data exists on the outcomes or Quality of Life (QOL) specific to the octogenarian population undergoing this procedure. We hypothesize the outcomes and risks would not be too dissimilar when compared to a younger cohort between 65-79 years. Methods: From a retrospective database we selected octogenarian pts compared to an age and sex matched control group, ages 65-79. Pre-ablation tests were performed as well as quality of life (QoL) and symptom inventories. Results of the ablation procedure, follow up QoL and symptom inventories, peri-procedure morbidity and freedom from AF or control of AF with anti-arrhythmic agents were compared between the 2 groups. Results: During follow-up (mean 2.3 ± 2.2 years), AF elimination (70% vs 81%, p 0.942) and AF control including those on antiarrhythmic agents (86% vs 86%, p 0.249) were compared. Conclusion: Outcomes of ablation in the octogenarians are highly favorable with no increase in procedural complications. Improvement in QOL scores is impressive in patients with advancing age. Comparison of variables between the Young-Old and the Octagenerian cohort of patients undergoing ablation of drug-refractory AF Comparison of variables between the Young-Old and the Octagenerian cohort of patients undergoing ablation of drug-refractory AF
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Abnormality
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( BMJ . 2017;358:j3448) Although survival of preterm babies has increased worldwide along with a decrease in severe neonatal morbidity, the risk of neurodevelopmental and behavioral disabilities continues to be high in these children. In fact, developmental delay has replaced survival as the major concern for children born preterm. Early identification of risk factors for neurodevelopmental delay could lead to improved access to formal evaluation and subsequent intervention, potentially resulting in better long-term outcomes for the children. The EPIPAGE-2 study is a population-based cohort study from France that is evaluating infants born between 22 and 34 weeks gestation. Previously published reports from the EPIPAGE study have analyzed survival data as well as severe neonatal morbidity over a 15-year time period. In the current study, the cohort was analyzed to determine neuromotor, sensory, and neurodevelopmental outcomes at 2 years corrected age for children born alive from 22 to 34 weeks’ gestation. Children from the cohort enrolled in 2011 were compared with the cohort from 1997.
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Objective
In this study, we obtained relevant data from a nationwide cohort database to investigate the risk of attention deficit-hyperactivity disorder (ADHD) in children with a history of febrile seizures (FS).Methods
We identified 1081 children with FS as the case cohort, and the date of diagnosis was used as an index date. Four controls were matched randomly with each case based on age, sex, urbanisation level, parents' occupation, and index date. We applied Cox9s proportional hazards regression to estimate the HR and CI of FS-associated ADHD.Results
After 11 years of follow-up, the incidence of ADHD for the FS and control cohorts is 7.83 and 4.72 per 1000 person-years, respectively. The FS cohort was 1.66 times more at risk of ADHD occurrence (95% CI 1.27 to 2.18) than the control cohort. The risk of developing ADHD increased in conjunction with the frequency of FS-related visits.Conclusions
FS may increase the risk of subsequent ADHD occurrence in children. Children who visited physicians for FS more than twice had a significantly higher cumulative incidence of ADHD.Cite
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The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).
Wheeze
Respiratory sounds
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