Associations of inflammation‐related proteome with demographic and clinical characteristics of people with HIV in South Africa
Junyu ChenQin HuiChang LiuJaysingh BrijkumarJohnathan A. EdwardsClaudia E. OrdóñezMatthew R. DudgeonHenry SunpathSelvan PillayPravi MoodleyDaniel R. KuritzkesMohamed Y. S. MoosaTooru NemotoVincent C. MarconiYan V. Sun
0
Citation
33
Reference
10
Related Paper
Abstract:
Abstract Purpose Elevated levels of inflammation associated with human immunodeficiency virus (HIV) infection are one of the primary causes for the burden of age‐related diseases among people with HIV (PWH). Circulating proteins can be used to investigate pathways to inflammation among PWH. Experimental design We profiled 73 inflammation‐related protein markers and assessed their associations with chronological age, sex, and CD4 + cell count among 87 black South African PWH before antiretroviral therapy (ART). Results We identified 1, 1, and 14 inflammatory proteins significantly associated with sex, CD4 + cell count, and age respectively. Twelve out of 14 age‐associated proteins have been reported to be associated with age in the general population, and 4 have previously shown significant associations with age for PWH. Furthermore, many of the age‐associated proteins such as CST5, CCL23, SLAMF1, MMP‐1, MCP‐1, and CDCP1 have been linked to chronic diseases such as cardiovascular disease and neurocognitive decline in the general population. We also found a synergistic interaction between male and older age accounting for excessive expression of CST5. Conclusions and clinical relevance We found that advanced age may lead to the elevation of multiple inflammatory proteins among PWH. We also demonstrated the potential utility of proteomics for evaluating and characterizing the inflammatory status of PWH.Keywords:
Neurocognitive
Proteome
Neurocognitive
Cite
Citations (19)
Cite
Citations (0)
Neurocognitive
SF-36
Cite
Citations (97)
Neurocognitive
Cite
Citations (0)
Background: Sexual risk behaviour is a global health concern.Unsafe sex practices increase the risk of HIV transmission to sex partners.This study assessed the knowledge of HIV transmission and sexual risk behaviours of patients accessing antiretroviral therapy (ART) in secondary health facility in Nigeria. Methods:In a cross sectional study, a study-specific questionnaire was self-administered to randomly selected 350 out of 5770 patients accessing ART.A midpoint of Likert-type scale was determined; and values above were positive while below were negative.Chi square was used for inferential statistics at 95% confidence interval.Results: Of participants, 57.1% were female and 28.6% aged ≥ 40years old.Knowledge of routes of HIV transmission and risk reduction associated with condom use was negative.Participants had positive attitudes to non-disclosure of HIV sero-status, multiple sex partners and unprotected sexual intercourse.Majority (63.7%) had one sex partner, 16% had >1 sex partners and 12.6% had none.Number of sex partners was associated with sex, marital and occupational status (P<0.05)unlike educational status; 66.2% of those who had one sex partners were married; 56.9% and 46.7% of those who had >1 sex partners were males and retirees respectively.Majority (66.3%) disclosed HIV sero-status to sex partners but only 62.6% knew HIV sero-status of their sex partners.Disclosure was associated with marital status (P<0.05)unlike sex and educational status.Only 28.9% consistently used condom during sexual intercourse; and 67.6% of them were aged >30 years old, while 55.7% were married.Consistent use of condom was associated with marital status and age (P<0.05)unlike educational status. Conclusion:There were poor knowledge of routes of HIV transmission and benefits of condom use.Few participants consistently used condom during sexual intercourse.Majority had one sex partner and disclosed HIV sero-status to sex partners.Ongoing counselling and education should be integrated into HIV prevention strategies.
Omics
Antiretroviral treatment
ANTIRETROVIRAL AGENTS
Cite
Citations (6)
Examine the cognitive effects of the KD diet in older
Neurocognitive
Ketogenic Diet
Cognitive Decline
Cite
Citations (0)
Individuals at clinical high risk for psychosis (CHR) exhibit neurocognitive deficits in multiple domains. The aim of this study is to investigate whether several components of neurocognition are predictive of conversion to psychosis.Fifty-two CHR individuals were assessed with the Structured Interview for Psychosis Risk Syndromes and completed a battery of neurocognitive tests at baseline including measures of executive functioning, attention, working memory, processing speed and reaction time. Neurocognitive functioning at baseline was scored based on an external normative control group. Most subjects were followed for 2.5 years to determine conversion status.Significant differences in neurocognitive functioning between CHR individuals and the control group were present in all domains. Twenty-six per cent of the participants converted to psychosis within 9.8 (standard deviation = 8.0) months on average (median 9 months), but there were no significant differences in neurocognition converters and non-converters.Individuals at CHR have deficits in neurocognitive functioning, but such deficits do not appear to be related to conversion risk.
Neurocognitive
Cite
Citations (9)
Neurocognitive
Cite
Citations (8)
Neurocognitive
Antiretroviral treatment
Cite
Citations (15)
Neurocognitive
Cite
Citations (2)