術前docetaxel＋oxaliplatin＋S-1療法により組織学的完全奏効を得た進行胃癌の１例
Satoru MiyaharaKazuhiro NishikawaTakuya HamakawaReishi ToshiyamaMasaaki MiyoYusuke TakahashiMasakazu MiyakeAtsushi MiyamotoTakeshi KatoMotohiro Hirao
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Abstract:
今回，われわれは術前DOS療法にて組織学的完全奏効が得られた進行胃癌の症例を経験したので報告する．症例は60歳の男性で，胃体上部小彎に２型病変を認め，生検結果は低分化型腺癌であった．CT検査では，No.１，３a，７に複数個，最大径30mmの腫大リンパ節を認め，審査腹腔鏡にて胃癌，cT3N2M0，cStage Ⅲと診断した．Bulkyリンパ節転移を伴う胃癌のため術前化学療法の方針とし，docetaxel＋oxaliplatin＋S-1療法を３コース行った．効果判定では原発巣とリンパ節の著明な縮小を認め，胃全摘とD2＋No.16a2int＋No.16b1latリンパ節郭清を施行した．病理組織学的には癌細胞の遺残を認めず，組織学的効果はGrade 3であった．高度リンパ節転移症例でも術前化学療法の著効により根治切除が可能となる場合があり，至適な化学療法レジメンについてのさらなる検討を要する．Cite
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Seperti pada dewasa, teknik regional anestesi pada pediatrik kini makin popular digunakan oleh ahli anestesikarena keuntungannya. Namun demikian selalu ada risiko dan kemungkinan timbulnya komplikasi dari setiap tindakan yang dilakukan, termasuk tindakan anestesi regional pada pediatrik. Insidensi komplikasi anestesi regional pada pediatrik tidak banyak, dan kalaupun terjadi komplikasi adalah minor. Komplikasi bisa diakibatkan dari identifikasi ruang saraf, alat, obat, teknis tindakan anestesi regionalnya dan komplikasi lainnya.Walaupun tidak banyak kejadian komplikasi regional anestesi yang dilaporkan pada pediatrik, dan bukanlah komplikasi yang fatal, teknik regional anestesi pada pediatrik harus dilakukan dengan lebih hatihati, pertimbangan risiko dan keuntungannya untuk menghindari terjadinya komplikasi, terlebih karena kebanyakan komplikasi dapat dihindari dengan mempelajari teknik yang benar, menggunakan peralatan yang sesuai, dan sangat menerapkan prinsip keamanan pada pasien dengan baik.
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Genentech is partnering with the German cancer company Affimed to develop immunotherapies for multiple kinds of solid and blood cancers. Affimed is developing therapies that engage natural killer cells of the innate immune system to help direct them to attack cancer cells. Genentech will pay Affimed $96 million up front and up to $5 billion more in potential payments.
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Objective To study the short-term efficacy and toxicities of docetaxel and oxaliplatin in the treatment of advanced gastric cancer.Methods 28 patients with advanced gastric cancer were treated with docetaxel(75mg/m2,d1),oxaliplatin(130mg/m2,d2).The chemotherapy was repeated every 21 to 28 days.Effacicy and toxicities were evaluated after 2 cycles of chemotherapy.Results There were 1 complete remission(CR),14 partial remission(PR),9 stabilization and 4 progression among 28 patients.The total effective rate was 53.57%.Conclusion Chemotherapy with docetaxel and oxaliplatin is effective in the treatment of patients with advanced gastric cancer with minimal and accepted toxicities.
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