Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection
Sunil K. AhujaMuthu Saravanan ManoharanGrace C. LeeLyle R. McKinnonJustin A. MeunierMaristella SteriNathan HarperEdoardo FiorilloAlisha M. SmithMarcos I. RestrepoAnne P. BranumMatthew J. BottomleyValeria OrrùFabio JimenezAndrew CarrilloLavanya PandrankiCaitlyn WinterLauryn WinterÁlvaro Andrés GaitánAlvaro MoreiraElizabeth WalterGuido SilvestriChristopher L. KingYong‐Tang ZhengHong‐Yi ZhengJoshua KimaniT. Blake BallFrancis A. PlummerKeith R. FowkePaul HardenKathryn J. WoodMartin T. FerrisJennifer M. LundMark T. HeiseNigel GarrettKristen R. CanadySalim S. Abdool KarimSusan J. LittleSara GianellaDavey M. SmithScott LetendreDouglas D. RichmanFrancesco CuccaHanh TrinhSandra Sanchez‐ReillyJoan M. HechtJose A. Cadena ZuluagaAntonio AnzuetoJacqueline A. PughMohamed I. AbdallaSylvia AdamsYemi AdebayoJoseph AgnewSaleem AliGregory M. AnsteadMarichu BalmesJennifer M. BarkerDeborah Baruch-BienenVelma BibleAngela BirdwellStacy BraddyStephen BradfordH. BriggsJudith Martín CorralJennifer J. DacusPatrick J. DanaherScott A. DePaulJill DickersonJollynn DoanneAamir EhsanSamantha ElbelMiguel EscalanteCorina EscamillaValerie EscamillaRobert FarrarDavid FeldmanDebra FloresJulianne FlynnDelvina FordJoanna D. FoyMegan Culler FreemanSamantha GalleyJessica Medina GarcíaMaritza GarzaS. Douglass GilmanMelanie GoelJennifer M. GómezVarun GoyalSally GrassmuckS GrigsbyJoshua A. HansonBrande HarrisAudrey HaywoodCecilia A. HinojosaTony T. HoTeri HopkinsLynn L. HorvathAneela HussainAli JaburPamela JewellThomas JohnsonAustin C. LawlerMonica LeeChadwick S. LesterStephanie M. LevineHaidee V. LewisAngel LouderCharmaine MainorRachel MaldonadoCelida MartinezYvette MartinezDiego J. MaselliC. MataNeil McElligottLaura MedlinMyra MirelesJoanna MorenoKathleen MorneauJulie MuetzSamuel B. MunroCharlotte MurrayAnoop M. NambiarDaniel NasseryRobert NathansonKimberly OakmanJane O’RorkeCheryl PadgettSergi Pascual-GuàrdiaMarisa PattersonGraciela PérezRogelio PerezRogelio PerezR. E. PhillipsPatrick B. PolkMichael A. PomagerKristy J. PrestonKevin C. ProudMichelle RangelTemple RatcliffeRenee L. ReichelderferEvan M. RenzJeanette RossTeresa RuddM. E. SánchezTammy SandersKevin C. SchindlerDavid SchmitRaj SehgalClaudio SolorzanoNilam J. SoniWin S. TamEdward J. TovarSadie A. Trammell VelasquezAnna R. TylerAnjuli VasquezMaria C. VelosoSteven G. VenticinqueJorge A. VillalpandoMelissa VillanuevaLauren VillegasMegan WalkerAndrew WallaceMaria WallaceEmily WangStephanie WickizerAndreia WilliamsonAndrea YunesKatharine H. ZentnerBrian K. AganRobert Root‐BernsteinRobert A. ClarkJason F. OkuliczWeijing He
51
Citation
106
Reference
10
Related Paper
Citation Trend
Abstract:
Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as the capacity to preserve and/or rapidly restore immune functions that promote disease resistance (immunocompetence) and control inflammation in infectious diseases as well as other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics that quantify the balance between (i) CD8 + and CD4 + T-cell levels and (ii) gene expression signatures tracking longevity-associated immunocompetence and mortality-associated inflammation. Profiles of IR metrics in ~48,500 individuals collectively indicate that some persons resist degradation of IR both during aging and when challenged with varied inflammatory stressors. With this resistance, preservation of optimal IR tracked (i) a lower risk of HIV acquisition, AIDS development, symptomatic influenza infection, and recurrent skin cancer; (ii) survival during COVID-19 and sepsis; and (iii) longevity. IR degradation is potentially reversible by decreasing inflammatory stress. Overall, we show that optimal IR is a trait observed across the age spectrum, more common in females, and aligned with a specific immunocompetence-inflammation balance linked to favorable immunity-dependent health outcomes. IR metrics and mechanisms have utility both as biomarkers for measuring immune health and for improving health outcomes.Keywords:
Immunocompetence
Stressor
Lifespan and longevity are related concepts in that both are measures of biological time. The qualifier that separates the two is that longevity requires a long lifespan. Both concepts are intertwined and from a biological perspective they define windows of time within which key milestones for Darwinian success must be met. Longevity is an essential part of how organisms adapt to the risks that endanger life or reproduction. Aging and longevity are quite different concepts that follow parallel paths. As longevity increases, so does the irreparable cellular damage accumulation arising from biochemical side reactions. The critical difference is that longevity has a genetic basis and aging does not.
Cite
Citations (0)
Immunocompetence
Trait
Positive correlation
Genetic correlation
Negative correlation
Cite
Citations (10)
The immunocompetence handicap hypothesis suggests that the immune system competes for resources with sexually selected ornaments; variation in ornaments might reflect genetic variation for immunocompetence. We tested this genetic prediction by mating scorpionfly females to males differing in the expression of a condition-dependent ornament trait, saliva secretion, and then comparing offspring immunocompetence. We found several indications of an immunocompetence handicap in our study: females had superior immunocompetence compared with males, the different immune traits were positively correlated, and there were indications of genetic variation in immune traits. However, we found no significant difference in the immunocompetence of offspring derived from males differing in ornament expression, only a tendency for sons of ornamented males to possess slightly better immunocompetence. The estimated effect of fathers on offspring immunocompetence was rather small, but it might be a sufficient benefit of female choice, provided that the costs of choice are small. We conclude that the genetic benefit of female choice is small concerning offspring immunocompetence, but the immunocompetence handicap principle might nevertheless work in scorpionflies.
Immunocompetence
Cite
Citations (101)
Limited evidence on healthy longevity was provided in the world, and no studies investigated the fractions of healthy longevity attributed to modifiable factors.
Healthy aging
Centenarian
Cite
Citations (1)
The allocation into T–cell–mediated immunocompetence was experimentally increased in 68 out of 139 nestlings by supplementary feeding methionine to half of the nestlings in 15 blue tit nests. Methionine–supplemented nestlings had an increased T–cell–mediated immunocompetence, but a reduced growth compared with control siblings. Nestlings that had low initial weights and nestlings that were supplemented with methionine had an increased mortality risk. The investment that nestling blue tits make in immunocompetence appears to be tightly controlled by survival costs paid through a trade–off between immunocompetence and growth.
Immunocompetence
Cite
Citations (155)
Cite
Citations (1)
The effects of temperature and nutrition on the adult longevity of Microplitis tuberculifer(Hymenoptera:Braconidae) were examined in laboratory.The results indicated that the adult longevity had significantly difference under different temperature conditions,which shortened with increasing of temperature.Water supply had no significant influence on adult longevity.Honey water can effectively extend adult longevity.The adult longevity was the longest(24.6±3.0 days for female and 13.8±2.5 days for male)at 18℃ with 20% honey water supply,which was the shortest(1.4±0.1 days for female and 13.8±2.5 days for male)at 30℃ without food supply.The longevity of female was longer than that of male under the same conditions.
Cite
Citations (1)
Immunocompetence
Cite
Citations (2)
This chapter contains sections titled: Summary: Sanitas Summum Bonus Introduction Orthogonal Pathways for Longevity in Mammals The Value of Different Model Systems Tools to Dissect Conserved Orthogonal Longevity Mechanisms Common Antiaging Mechanisms and Longevity Pathways Insights on Pure Human Mechanisms of Longevity Come from Centenarians The Most Promising Approach to Increase Longevity: Sirtuins, SREBP, and Resveratrol CR/DR (Without Malnutrition) is Key to Gain Health and Longevity The Real Prototype for Longevity, Vitality, and Fertility: Queen Honeybee Can we Learn from Queen Honeybee's Longevity? Yes, we can Ad Meliorem – Conclusion and Perspective for Longevity in Humans References
Queen (butterfly)
Vitality
Cite
Citations (0)