Neuroimaging Correlates of Treatment Response to Transcranial Magnetic Stimulation in Bipolar Depression: A Systematic Review
Ahmad ShamabadiHanie KarimiGiulia CattarinussiHossein Sanjari MoghaddamShahin AkhondzadehFabio SambataroGiandomenico SchienaGiuseppe Delvecchio
4
Citation
52
Reference
10
Related Paper
Citation Trend
Abstract:
Transcranial magnetic stimulation (TMS) has become a promising strategy for bipolar disorder (BD). This study reviews neuroimaging findings, indicating functional, structural, and metabolic brain changes associated with TMS in BD. Web of Science, Embase, Medline, and Google Scholar were searched without any restrictions for studies investigating neuroimaging biomarkers, through structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), functional MRI (fMRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), and single photon emission computed tomography (SPECT), in association with response to TMS in patients with BD. Eleven studies were included (fMRI = 4, MRI = 1, PET = 3, SPECT = 2, and MRS = 1). Important fMRI predictors of response to repetitive TMS (rTMS) included higher connectivity of emotion regulation and executive control regions. Prominent MRI predictors included lower ventromedial prefrontal cortex connectivity and lower superior frontal and caudal middle frontal volumes. SPECT studies found hypoconnectivity of the uncus/parahippocampal cortex and right thalamus in non-responders. The post-rTMS changes using fMRI mostly showed increased connectivity among the areas neighboring the coil. Increased blood perfusion was reported post-rTMS in PET and SPECT studies. Treatment response comparison between unipolar depression and BD revealed almost equal responses. Neuroimaging evidence suggests various correlates of response to rTMS in BD, which needs to be further replicated in future studies.Cite
Citations (29)
Abstract With the development of functional neuroimaging tools, the past two decades have witnessed an explosion of work examining functional brain maps, mostly in the adult brain. Against this backdrop of work in adults, developmental research begins to gather a substantial body of knowledge about brain maturation. The purpose of this review is to present some of these findings from the perspective of functional neuroimaging. First, a brief survey of available neuroimaging techniques (i.e., fMRI, MRS, MEG, PET, SPECT, and infrared techniques) is provided. Next, the key cognitive, emotional, and social changes taking place during adolescence are outlined. The third section gives examples of how these behavioral changes can be understood from a neuroscience perspective. The conclusion places this functional neuroimaging research in relation to clinical and molecular work, and shows how answers will ultimately come from the combined efforts of these disciplines. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008
Developmental cognitive neuroscience
Cite
Citations (82)
Nothing
Cite
Citations (82)
This Viewpoint discusses the current lack of evidence of functional neuroimaging affecting patient outcomes in parkinsonian conditions.
Cite
Citations (1)
Findings from neuroimaging studies complement our understanding of the wide-ranging neurobiological changes in trauma survivors who develop post-traumatic stress disorder (PTSD).To determine whether neuroimaging studies had identified structural and functional changes specific to PTSD.A review of all functional and structural neuroimaging studies of subjects with PTSD was carried out. Studies were identified using general medical and specific traumatic stress databases and paper searches of current contents and other secondary sources.The most replicated structural finding is hippocampal volume reduction, which may limit the proper evaluation and categorisation of experience. Replicated localised functional changes include increased activation of the amygdala after symptom provocation (which may reflect its role in emotional memory) and decreased activity of Broca's area at the same time (which may explain the difficulty patients have in labelling their experiences).Evidence from neuroimaging studies has suggested areas of the brain that may be damaged by psychological trauma. The clinical implications of these neuroimaging findings need to be investigated further because they challenge traditional therapeutic approaches.
Cite
Citations (310)
From a neuroimaging perspective, the changes that occur over the lifespan in brain structure and functional capacity, both developmental and degenerative, must be considered in combination with the cognitive, behavioral, and psychosocial status of an individual when utilizing neuroimaging for either clinical or research purposes. In this chapter we selectively review some common conventional neuroimaging techniques and their application, followed by discussion of advanced structural and functional neuroimaging methods and likely future directions.
Cite
Citations (3)
Abstract This chapter focuses on the contribution and goals of functional neuroimaging. It presents a detailed discussion on the goals of functional neuroimaging, including neuroanatomical localization of cognitive processes, testing current theories of cognition, and neural models. The chapter reviews the work of functional neuroimaging in cognitive science and looks into its progress, and, finally, addresses questions related to functional neuroimaging and cognitive neuroimaging studies.
Cite
Citations (12)
Abstract: Conversion disorder (CD) is a syndrome of neurological symptoms arising without organic cause, arguably in response to emotional stress, but the exact neural substrates of these symptoms and the underlying mechanisms remain poorly understood with the hunt for a biological basis afoot for centuries. In the past 15 years, novel insights have been gained with the advent of functional neuroimaging studies in patients suffering from CDs in both motor and nonmotor domains. This review summarizes recent functional neuroimaging studies including functional magnetic resonance imaging (fMRI), single photon emission computerized tomography (SPECT), and positron emission tomography (PET) to see whether they bring us closer to understanding the etiology of CD. Convergent functional neuroimaging findings suggest alterations in brain circuits that could point to different mechanisms for manifesting functional neurological symptoms, in contrast with feigning or healthy controls. Abnormalities in emotion processing and in emotion-motor processing suggest a diathesis, while differential reactions to certain stressors implicate a specific response to trauma. No comprehensive theory emerges from these clues, and all results remain preliminary, but functional neuroimaging has at least given grounds for hope that a model for CD may soon be found. Keywords: conversion disorder, neuroimaging, functional neurology, hysteria, mechanisms A Letter to the Editor has been recieved and published for this article. Corrigendum for this paper has been published
Functional Imaging
Conversion disorder
Diathesis
Cite
Citations (30)
Post-traumatic stress disorder(PTSD) is a serious problem that affects people who have been exposed to the traumatic events(e.g.,combat,childhood abuse).Over the past several years,there are increasing neuroimaging studies that have focused on this disorder,especially the functional neuroimaging ones.Functional neuroimaging plays an important role in uncovering the abnormal brain regions and neuronal circuitry that mediate PTSD.In this paper,we reviewed the functional neuroimaging findings in patients with PTSD,and suggested possible directions for future research.
Traumatic stress
Cite
Citations (0)
We review the data from structural neuroimaging studies (computed tomography and magnetic resonance imaging) related to depressive disorders. In addition, we review the relevant functional neuroimaging research, including studies of normal emotional processing, studies of the functional neuroanatomy of major depression, and neurochemical neuroimaging studies of depression. Finally, we discuss existing neurobiological models of depression and offer modifications based upon the body of neuroimaging research we have presented.
Neuroanatomy
Neurochemical
Depression
Functional Imaging
Cite
Citations (70)