LINC00665 contributes to cholangiocarcinoma progression by modulating IRF1/PD-L1
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Abstract Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in human cancers. However, the underlying biological functions and mechanisms of lncRNAs in cholangiocarcinoma (CCA) remain unclear. Here, we found that LINC00665 expression was increased in CCA tumour samples and that LINC00665 expression was p negatively correlated with survival rate in CCA patients. Our observations showed that LINC00665 promoted the proliferation, migration and invasion of CCA cells in vitro and in vivo. In addition, we found that LINC00665 interacts with IRF1 and increases IRF1 protein levels. LINC00665 promotes tumour progression phenotypes in part by regulating IRF1. In addition, LINC000665 can increase the expression of PD-L1 and promote tumour immune escape. These results suggest that LINC00665 is an oncogene and that the inhibition of LINC00665 expression may be a new therapeutic target for cholangiocarcinoma.Keywords:
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