Supplementary Figures S1-S3 from Integrative Genomic Analyses Yield Cell-Cycle Regulatory Programs with Prognostic Value
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Value (mathematics)
Stochastic dominance
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Sampling distribution
Bootstrapping (finance)
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In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which p53 acetylation is regulated is still unclear. Here, we describe an essential role for HLA-B-associated transcript 3 (Bat3)/Scythe in controlling the acetylation of p53 required for DNA damage responses. Depletion of Bat3 from human and mouse cells markedly impairs p53-mediated transactivation of its target genes Puma and p21 . Although DNA damage-induced phosphorylation, stabilization, and nuclear accumulation of p53 are not significantly affected by Bat3 depletion, p53 acetylation is almost completely abolished. Bat3 forms a complex with p300, and an increased amount of Bat3 enhances the recruitment of p53 to p300 and facilitates subsequent p53 acetylation. In contrast, Bat3-depleted cells show reduced p53–p300 complex formation and decreased p53 acetylation. Furthermore, consistent with our in vitro findings, thymocytes from Bat3-deficient mice exhibit reduced induction of puma and p21, and are resistant to DNA damage-induced apoptosis in vivo. Our data indicate that Bat3 is a novel and essential regulator of p53-mediated responses to genotoxic stress, and that Bat3 controls DNA damage-induced acetylation of p53.
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This paper analyzes the effect of the land size and the family labor hours on the technical efficiencies of Korean fruit (apple, pear, grape, and peach) farms which are measured with Data Envelopment Analysis. It follows the estimation method suggested by Simar and Wilson(2007) by using truncated regression, (instead of the censored regression model which are prevalent in the empirical works) and bootstrapping, in order to adjust for the bias of the simple DEA and to estimate the confidence interval of the estimates, taking into account the serial correlation of the error terms and their correlation with the explanatory variables which are intrinsic to DEA estimates. The estimation results show that the family labor hours enhance the technical efficiency of grape growing. They also suggest that the choice between the censored regression and the truncated regression model may have important consequence on the estimation results.
Censored regression model
Tobit model
Bootstrapping (finance)
Truncation (statistics)
Local regression
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Canonical correlation
Sample (material)
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTYield Value of Commercial Soaps.Robert D. Vold and Luther L. LyonCite this: Ind. Eng. Chem. 1945, 37, 5, 497–504Publication Date (Print):May 1, 1945Publication History Published online1 May 2002Published inissue 1 May 1945https://pubs.acs.org/doi/10.1021/ie50425a030https://doi.org/10.1021/ie50425a030research-articleACS PublicationsRequest reuse permissionsArticle Views41Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Value (mathematics)
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HLA-B-associated transcript 3 (BAT3) was originally identified as one of the genes located within human major histocompatibility complex. It encodes a large proline-rich protein with unknown function. In this study, we found that a fragment of the BAT3 gene product interacts with a candidate tumor suppressor, DAN, in the yeast-based two-hybrid system. We cloned the full-length rat BAT3 cDNA from a fibroblast 3Y1 cDNA library. Our sequence analysis has demonstrated that rat BAT3 cDNA is 3617 nucleotides in length and encodes a full-length BAT3 (1098 amino acids) with an estimated molecular mass of 114,801 daltons, which displays an 87.4% identity with human BAT3. The deletion experiment revealed that the N-terminal region (amino acid residues 1-80) of DAN was required for the interaction with BAT3. Green fluorescent protein-tagged BAT3 was largely localized in the cytoplasm of COS cells. Northern hybridization showed that BAT3 mRNA was expressed in all the adult rat tissues examined but predominantly in testis. In addition, the level of BAT3 mRNA expression was more downregulated in some of the transformed cells, including v-mos- and v-Ha-ras-transformed 3Y1 cells, than in the parental cells.
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SUMMARY A hitherto unrecorded virus having flexible rod‐shaped particles about 740–760 × 13 nm was isolated from Anthoxanthum odoratwn L. It was transmitted by sap inoculation, but not by several species of insect, seed or soil to 18 species of Gramineae including wheat, oats and barley. In susceptible species the virus normally produced a mosaic mottling of the leaves which was sometimes followed by a necrotic streaking or striping.
Mosaic virus
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Rank correlation is one of the most useful statistical techniques available for the treatment of data arising in experimental and applied psychological research. Chambers (1946) has indicated the type of data most frequently occurring in these fields, and has pointed out the advantages of Kendall's r over Spearman's p or any form of transformation to ordinal form. Given the use of T when tied rankings are present (Kendall, 1946) it seemed possible to extend the method to cover a very common problem in psychology, namely, determination of the relation between two variables, one of which is expressed as a ranking and the other as a dichotomy. In applied or field work the relation of a psychological 'measurement' and an external criterion nearly always appears in this form. The usual method of determining the relationship consists of reducing the ranking to a dichotomy and calculating x2 for the 2 x 2 table which results. That this may lead to inaccuracy can be seen from the following example:
Rank correlation
Rank (graph theory)
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For 1 < r < + ∞ , we find the least value α and the greatest value β such that the inequality H α ( a , b ) < A r ( a , b ) < H β ( a , b ) holds for all a , b > 0 with a ≠ b . Here, H ω ( a , b ) and A r ( a , b ) are the generalized Heronian and the power means of two positive numbers a and b , respectively.
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There is growing frustration with the concept of the
Value (mathematics)
p-value
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